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ESTABLISHMENT OF IMMUNOSUPPRRESIVE METHOD FOR CLINICAL XENOTRANSPLANTATION

Research Project

Project/Area Number 06454400
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionOSAKA UNIVERSITY

Principal Investigator

SHIRAKURA Ryota  Osaka Univ Med School Professor, 医学部, 教授 (00116047)

Co-Investigator(Kenkyū-buntansha) FKUSHIMA Norihide  Osaka Univ Med School Assistant Professor, 医学部, 助手 (30263247)
SAWA Yoshiki  Osaka Univ Med School Assistant Professor, 医学部, 助手 (00243220)
NAKATA Seizo  Osaka Univ Med School Assistant Professor, 医学部, 助手 (50116068)
SHIMAZAKI Yasuhisa  Osaka Univ Med School Associate Professor, 医学部, 助教授 (60116043)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 1995: ¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 1994: ¥2,900,000 (Direct Cost: ¥2,900,000)
KeywordsXENOGRAFTS / BABOON / PIG / GUIDELINE / 異種心移植
Research Abstract

A.Guideline for use of non-human primates in Osaka University Animal Research Center
As non-human primates are rare and similar to human, it is important to take care of non-human primates as human. We made guidelines for use of non-human primate which was approved in Osaka University Animal Research Committee.
B.Immunological Assessment of Baboon and Pigs
1)Establishment of assay of anti-pig antibody (against red blood cells by titration method and against endothelial cells or leukocytes by ELISA)
2)Mixed lymphocyte culture (MLC) of baboon lymphocytes against pig lymphocytes
3)Assay of subpopulation of baboon lymphocytes using anti-human lymphocytes

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] S. Miyagawa: "Effects of transfected complement regulatory proteins MCP, DAF, and MCP/DAF hybrid, on conylement mediated suine endothelial cell lysis" Transplantation. 58. 834-840 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S. Miyagawa: "Effect of transfected MAeIF(CD59) on conylement mediated suine endothelial cell lysis, conysaied with those of MCP(CD46) and DAF(CD55)" Transplantation Procedings. 27. 328-329 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 福嶌教偉: "異種移植の拒絶反応のメカニズムとモニタリング" 今日の移植. 9. 5-13 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 白倉良太: "異種移植の現況と展望" 今日の移植. 8. 269-274 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S Miyagawa, R Shirakura, S Nakata et al.: "Effects of transfected complement regulatory proteins, MCP,DAF,and MCP/DAF hybrid, on complement mediated swine endothelial cell lysis." Transplantation. 58. 834-40 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S Miyagawa.R Shirakura, S Nakata, et al.: "Effects of transfected MACIF (CD59) on complement mediated swine endothelial cell lysis, compared with those of MCP (CD46) and DAF (CD55)." Transplant Proc. 27. 328-9 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] N Fukushima, H Matsuda.: "Mechanism and Monitoring of Rejection in Xenografts." Transpalantation Today. 9 (1). 5-13 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S.Miyagawa: "Effects of fransfected conglenet Negutatnory proteins MCP.DAFad Mep/DAF byhrid on conpleinet nedcated cell lyes." Trasplantation. 58. 834-840 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 福嶌教偉: "異種移植における拒絶反応のメカニズムとモニタリング" 今日の移植. 1. 5-13 (1996)

    • Related Report
      1995 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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