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Investigation for pathogenesis of syringomyelia with Chiari I malformation and its optimal surgical management.

Research Project

Project/Area Number 06454406
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionUniversity of Hokkaido

Principal Investigator

ABE Hiroshi  sch.of Med, University of Hokkaido Professor, 医学部, 教授 (80000983)

Co-Investigator(Kenkyū-buntansha) HIDA Kazutoshi  sch.of Med, University of Hokkaido Assistant Professor, 医学部附属病院, 助手 (10238305)
IWASAKI Yoshinobu  sch.of Med, University of Hokkaido Associate Professor, 医学部, 助教授 (00113522)
小柳 泉  北海道大学, 医学部, 助手 (40250435)
Project Period (FY) 1994 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥7,700,000 (Direct Cost: ¥7,700,000)
Fiscal Year 1996: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1995: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1994: ¥5,300,000 (Direct Cost: ¥5,300,000)
KeywordsSyringomyelia / Chiari malformation / Syringomyelia / Chiari malformation / MR imaging / Mr imaging
Research Abstract

Syringomyelia has been considered as a rare and difficult disease to treat. Recent development of diagnostic imageing modality and microsurgical technique, however, enabled us to find and surgially treat more numbers of patients in a less-invasive and safe manner.
Ftiology of syringomyelia has been controversial, although several pathogenesis has been proposed. We have performed the clinical reserach regarding with etiology of this disease. We have used the rabbit model received spinal cord injury and demonstrated that posttraumatic arachnoiditis was produced by the disrupted CSF circulation due to adhesive arachnoiditis as well as by the disturbed blood circulation in spinal cord itself. Although we do not have an animal model of syringomyelia associated with Chiari maldormation, we are performing the pathological analysis in the rat model, in which tonsilar herniation was mimiced with the obstruction of foramen magnum and upper cerical spinal cannal with a balloon catheter.
We have surgically treated more than 140 patients with syringomyelia developing novel surgical techniques. Our clinical reserach was mainly focued on the following items : (1) We have quantitatively evaluated the CSF circulatiion of the patients with syringomyelia using with cine-MRI and pre-saturation band. In this study, disturbed CSF circlation at the cranio-vertebral junction profundly related to the pathogenesis of syringomyelia. (2) We have made a modification of our-own-made syrinx-subarachnoid shunt system (Sapporo Shunt) and reduced the risk of the obstruction of the shunt system. (3) We did further investigation about the etiological factors associated with the syringomyelia. In the patients with syringomelia, perioperative problems such as abnormal presentation, birth injuries, or neonatal asphyxia, are revealed ot be significantly more frequent.

Report

(4 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • 1994 Annual Research Report
  • Research Products

    (42 results)

All Other

All Publications (42 results)

  • [Publications] 黒田敏,他: "Chiari奇形を合併した脊髄空洞症の髄液循環動態" 脳神経. 46(1). 59-64 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kazutoshi Hida, et al: "Birth injury as a cause of syringomyelia" J Neurol Neurosurg Psychiatry. 57. 373-374 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ki Hong Cho et al: "Experimental model of posttraumatic syringomyelia : the role of adhesive arachnoiditis in syrinx formation" J Neurosurgery. 80. 133-139 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 飛騨一利 他: "Chiari奇形を伴った脊髄空洞症患者の周産期疫学調査" 小児の神経. 19. 215-219 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 飛騨一利 他: "脊髄空洞症の病態および外科治療" NEUROSURGEONS. 13. 187-193 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 飛騨一利 他: "脊髄空洞症に対する外科治療 -大後頭孔部減圧術と空洞-クモ膜下腔交通術-" Spinal Surgery. 8. 7-11 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Hida,et al: "Post-traumatic syringomyelia" Neurosurgery. 35(5). 886-891 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] K.Hida,et al: "Surgical treatment of syringomyelia-Comparison between FMD and S-S shunt-Neurosurgery" Neurosurgery. 37(4). 291-295 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 岩崎喜信 他: "Syringomyeliaの手術" 脳神経外科. 24(8). 709-716 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 飛騨一利 他: "最新脳神経外科学" 朝倉書店, 1200 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Satoshi Kuroda, Hitoshi Matsuzawa, Yoshinobu Iwasaki, Kazutoshi Hida, Hiroyuki Imamura, Hiroshi Abe, Hisatoshi Saito: "CSF Dynamics in the Patients with Syringomyelia Associated with Chiari Malformation -Quantitative Analysis on Cine MRI-" No To Sinkei. 46 (1). 59-64 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kazutoshi Hida, Yoshinobu Iwasaki, Hiroyuki Imamura, Hiroshi Abe: "Birth injury as cause of syringomyelia" J Neurol Neurosurg Psychiatry. 57. 373-374 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ki Hong Cho, Yoshinobu Iwasaki, Hiroyuki Imamura, Kazutoshi Hida, Hiroshi Abe: "Experimental model of posttraumatic syringomyelia : the role of adhesive arachnoiditis in syrinx formation" J Neurosurgery. 80. 133-139 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kazutoshi Hida, Yoshinobu Iwasaki, Hiroyuki Imamura, Hiroshi Abe: "Epidemiological Studies of Perinatal Syringomyelia with Chiari Type Malformation" Nervous System in Children. 19. 215-219 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kazutoshi Hida, Yoshinobu Iwasaki, Hiroshi Abe: "Surgical management of syringomyelia" NEUROSURGEONS. 13. 187-193 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kazutoshi Hida, Yoshinobu Iwasaki, Hiroshi Abe: "Surgical management of syringomyelia Surgical management of syringomyelia ; FMD and S-S shunt" Spinal Surgery. 8. 7-11 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kazutoshi Hida, Yoshinobu Iwasaki, Hiroyuki Imamura, Hiroshi Abe: "Post-traumatic syringomyelia" Neurosurgery. 35. 886-891 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kazutoshi Hida, Yoshinobu Iwasaki, Koyanagi Izumi, Yutaka Sawamura, Hiroshi Abe: "Surgical treatment of syringomyelia-Comparison between FMD and S-S shunt-Neurosurgery" Neurosurgery. 37 (4). 291-295 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Yoshinobu Iwasaki, Hiroshi Abe: "Surgical treatment for syringomyelia" Neurological surgery. 24 (8). 709-716 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kazutoshi Hida, Hiroshi Abe: "Congenital Syringomyelia" New Neurosurgery. 645-649 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 黒田 敏 他: "Chiari奇形を合併した脊髄空洞症の髄液循環動態" 脳神経. 46(1). 59-64 (1994)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kazutoshi Hida, et al: "Birth injury as a cause of syringomyelia" J Neurol Neurosurg Psychiatry. 57. 373-374 (1994)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ki Hong Cho et al: "Experimental model of posttraumatic syringomyelia : the role of adhesive arachnoiditis in syrinx formation" J Neurosurgery. 80. 133-139 (1994)

    • Related Report
      1996 Annual Research Report
  • [Publications] 飛騨一利 他: "Chiari奇形を伴った脊髄空洞症患者の周産期疫学調査" 小児の神経. 19. 215-219 (1994)

    • Related Report
      1996 Annual Research Report
  • [Publications] 飛騨一利 他: "脊髄空洞症の病態および外科治療" NEUROSURGEONS. 13. 187-193 (1994)

    • Related Report
      1996 Annual Research Report
  • [Publications] 飛騨一利 他: "脊髄空洞症に対する外科治療-大後頭孔部減圧術と空洞-クモ膜下腔交通術-" Spinal Surgery. 8. 7-11 (1994)

    • Related Report
      1996 Annual Research Report
  • [Publications] K Hida, et al: "Post-traumatic syringomyelia" Neurosurgery. 35(5). 886-891 (1994)

    • Related Report
      1996 Annual Research Report
  • [Publications] K. Hida, et al: "Surgical treatment of syringomyelia-Comparison between FMD and S-S shunt-Neurosurgery" Neurosurgery. 37(4). 291-295 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] 岩崎喜信 他: "Syringomyeliaの手術" 脳神経外科. 24(8). 709-716 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 飛騨一利 他: "最新脳神経外科学" 朝倉書店, 1200 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kazutoshi Hida: "Surgical Indication and Results of Foramen Magnum Decompression Versus Syringosubarachnoid Shunting for Syringomyelia Associated with Chiari Malfomation" Neurosurgery. 37. 673-679 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 阿部 弘: "Chiari奇形を伴った脊髄空洞症に対する外科治療" 脊髄空洞症及び二分脊椎症に伴う脊髄病態及び治療に関する研究 平成6年度研究報告書. 83-89 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 阿部 弘: "二分脊椎症に伴った脊髄空洞症の治療" 脊髄空洞症及び二分脊椎症に伴う脊髄病態及び治療に関する研究 平成6年度研究報告書. 115-121 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 阿部 弘: "Chiari奇形を合併した脊髄空洞症の髄液循環動態-cine MRIを用いた検討-" 脊髄空洞症及び二分脊椎症に伴う脊髄病態及び治療に関する研究 平成6年度研究報告書. 73-77 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 岩崎喜信: "Chiari奇形を伴う脊髄空洞症の外科的治療(治療の選択と手術手技)" Orthopaedics. 8. 35-41 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 小柳 泉: "脊髄損傷の治療" Clinical Neuroscience. 13. 88-90 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hiroshi Abe: "Post-traumatic syringomyelia" Neurosurgery. 35. 886-891 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 飛騨 一利: "脊髄空洞症に対する外科的治療-大後頭孔部減圧術と空洞-クモ膜下腔交通術-" Spinal Surgery. 8. 7-11 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 飛騨 一利: "脊髄空洞症の病態および外科治療" NEUROSURGEONS. 13. 187-193 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 飛騨 一利: "Chiari奇形を伴った脊髄空洞症患者の周産期疫学調査" 小児の神経. 19. 215-219 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hiroshi Abe: "Experimental model of posttraumatic syringomyelia:the role of adhesive arachnoiditis in syrinx formation" J Neurosurgery. 80. 133-139 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Hiroshi Abe: "Birth injury as a cause of syringomyelia" J Neurol Neurosurg Psychiatry. 57. 373-374 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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