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Effect of Spinal Cord Ischemia on Spinal Cord Evoked Potetials in the Canine

Research Project

Project/Area Number 06454431
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionHIROSHIMA UNIVERSITY

Principal Investigator

HUJIMOTO Yoshinori  Hiroshima Univ., Medical Hospital, Assistant Prof., 医学部・附属病院, 講師 (30199377)

Co-Investigator(Kenkyū-buntansha) SUEDA Taijiro  Hiroshima Univ., School of Medicine, Associate Prof., 医学部, 助教授 (10162835)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1994: ¥4,700,000 (Direct Cost: ¥4,700,000)
KeywordsAortic occlusion / Spinal cord ischemia / Paraplegia / Evoked spinal cord potential
Research Abstract

In eight anesthetized canines that had arterial ischemia produced by crossclamping of thoracic aorta, evoked spinal cord potentials (ESCP) and aciatic nerve spinal cord potentials (sciatic ESCP) were recorded. And their waveforms and amplitudes were compared. Further, after 48-hour the completion of experiment, the spinal cord from T-1 to S-5 was removed en bloc and studied pathohistologically. In the electrophysiological findings, the recovery ratio of the N2 amplitude of the ESCP,the N3 amplitude of ESCP and the sciatic ESCP recorded at the level of intumescentia lumbaris was correlated with the histopathological damages and neurological outcome. Histopathologic examination of the cord revealed that ischemic changes were especially found at the greater portion from lower thoracic region to intumescentia lumbaris and their changes were differentiated each levels. And posterior horns were damaged rather than anterior horns at intumescentia lumbaris, therefore it is necessary to monitor the N3 amplitude of ESCP and the sciatic ESCP.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] 田中信: "脊髄虚血が脊髄誘発電位に及ぼす影響について(第1報)" 脊髄電気診断学. 17. 65-68 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Shin Tanaka: "Effect of Spinal Cord Ischemia on Spinal Cord Evoked Potentials in the Dog" The Journal of Electrodiagnosis of the Spinal Cord. Vol.17. 65-68 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 田中信: "脊髄虚血が脊髄誘発電位に及ぼす影響について(第1報)" 脊髄電気診断学. 17. 65-68 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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