| Project/Area Number |
06454447
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | KYOTO PREFECTURAL UNIVERSITY OF MEDICINE |
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Principal Investigator |
HOSOKAWA Toyoshi KYOTO PREFECTURAL UNIVERSITY OF MEDICINE MEDICINE ASSOCIATE PROFESSOR, 医学部, 教授 (80165555)
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| Co-Investigator(Kenkyū-buntansha) |
OMORI Misako KYOTO PREFECTURAL UNIVERSITY OF MEDICINE MEDICINE ASSISTANT PROFESSOR, 医学部, 助手 (60264777)
藤原 昭宏 京都府立医科大学, 医学部, 助手 (90238626)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥7,600,000 (Direct Cost: ¥7,600,000)
Fiscal Year 1995: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1994: ¥5,500,000 (Direct Cost: ¥5,500,000)
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| Keywords | ANESTHESIA / ENDOCRINE SYSTEM / IMMUNE / SURGICAL STRESS / SYMPATHETIC NERVE SYSTEM / CENTRAL NERVOUS SYSTEM / PAIN / STELLATE GANGLION / 異常神経節 / 手術 / 疼痛 / 星状神経節ブロック / 反射性交感神経性萎縮症 |
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| Research Abstract |
(1) Stress during Surgery and Immunological Reaction
Immuno-suppressive changes occured on the patients anesthetized with inhalation anesthesia itself or NLA during major surgery. General anesthesia with epidural block or splanchnic nerve block inhibit this changes.
(2) Stress during Surgery and Plasma Cortisol Concentration
General anesthesia with epidural block never depressed the increase of plasma cortisol concentration during upper abdominal surgery. The planchnic nerve block depressed the increase of plasma cortisol concentration significantly.
(3) Sympathetic Nerve System
Some kinds of stress including surgical stress and pain stress influence Sympathetic Nerve System.
Quantitative analysis of pain can be evaluated by monitoring changes in the blood flow and sweating. We utilized this method and evaluated the sympathetic nerve system responce to noxious stimulation.
(4) Reflex Sympathetic Dystrophy (RSD)
Our data suggest that the autonomic disturbance in incurable RSD are due to supersensitivity to sympathetic neurotransmitters rather than due to sympathetic overactivity.
(5) Laser
We evaluated the effect of low-reactive level laser by irradiateing to stellate ganglion.
(6) Cytokine
To examine the role of spleen under the surgical stress, we investigated the changes of plasma cytokine levels in the splenic vein blood and the arterial blood. The data suggested that the spleen produces intensively IL-6 under surgical stress.
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