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Basic and Clinical research for otitis media sequelae

Research Project

Project/Area Number 06454486
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

TAKAHASHI Haruo  Dept.of Speech & Hearing Science, Sch.of Medical, Kyoto Univ. Assistant Professor, 医学研究科, 講師 (90171511)

Co-Investigator(Kenkyū-buntansha) SUGIMARU Tadahiko  Dept.of Speech & Hearing Science, Sch.of Medical, Kyoto Univ. Instructor, 医学研究科, 助手 (20263072)
MIURA Makoto  Dept.of Speech & Hearing Science, Sch.of Medical, Kyoto Univ. Instructor, 医学研究科, 助手 (70263077)
KURATA Kyosuke  Dept.of Speech & Hearing Science, Sch.of Medical, Kyoto Univ. Instructor, 医学研究科, 助手 (80225242)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥6,100,000 (Direct Cost: ¥6,100,000)
Fiscal Year 1995: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1994: ¥3,700,000 (Direct Cost: ¥3,700,000)
KeywordsOtitis media / Cholesterol granuloma / Eustachian tube / Macrolide / Steroid / 浸出性中耳炎
Research Abstract

The aim of this study was focused on the development of new treatments for intractable otitis media with effusion (OME) in children and adolescents which cause most of the middle ear inflammatory diseases in adults.
Low-dose long-term macrolide administration was found to be effective in the treatment of intractable otitis media with effusion (OME) accompanying nasal sinusitis.
For cholesterol granuloma, a combination of peroral steroid (0.5-1.0 mg/kg per day of prednisolone tapering for 10-14 days) and transtympanic ventilation tube insertion resulted in a good outcome.
For intractable OME accompanying a eustachian tube with excessive patency, injection of athero collagen into submucosal space of the eustachian tube guided by an endoscope was found to be effective.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] Takahashi H, et al: "Eustachian tube compliance in cleft palate - a preliminary sutdy." Laryngoscope. 104. 83-86 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 高橋晴雄,他: "滲出性中耳炎に対する耳管通気の意義." 耳鼻臨床. 87. 735-746 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 高橋晴雄,他: "笑気ガスによる中耳ガス交換能評価の試み." 耳鼻臨床. 87. 885-889 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 藤田明彦,他: "難治性滲出性中耳炎に対するCAM少量長期投与の効果." 耳鼻臨床. 87. 1287-1291 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takahashi H, et al: "Assessment of gas exchange function of middle ear using nitrous oxide- a preliminary study." Acta Otolayngol(Stockh). 114. 643-646 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 藤田明彦,他: "難治性滲出性中耳炎と中耳真珠腫." 耳鼻臨床. 87. 755-759 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] たか橋晴雄,他: "中耳コレステリン肉芽腫の新しい治療-ステロイド内服と鼓膜チューブ留置-" 耳鼻臨床. 88. 863-866 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] たか橋晴雄: "滲出性中耳炎の耳管障害の病態" Otol Jpn. 5. 194-198 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takahashi H,Honjo I,Fujita A :"Eustachian tube compliance in cleft palate - a preliminary study" Laryngoscope. 104. 83-86 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takahashi H,Fujita A :"Effect on otitis media with effusion of inflation through eustachian tube" Pract Otol (Kyoto). 87. 735-746 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takahashi H,Honjo I,Kurata K,et al.: "Assessment of middle ear gas exchange using nitrous oxide." Pract Otol (Kyoto). 87. 885-889 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Fujita A,Kurata K,Takahashi H,et al :"Effect of low-dose long-term clarithromycin on refractory otitis media with effusion." Pract Otol (Kyoto). 87. 1287-1291 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takahashi H,Sugimaru T,Honjo I,et al :"Assessment of gas exchange function of middle ear using nitrous oxide." Acta Otolaryngol. 114. 643-646 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Fujita A,Kurata K,Takahashi H,et al.: "Refractory otitis media with effusion and cholesteatoma." Pract Otol (Kyoto). 88. 755-759 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takahashi H, et al: "Eustachian tube compliance in cleft palate -a preliminary sutdy." Laryngoscope. 104. 83-86 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 高橋晴雄,他: "浸出性中耳炎に対する耳管通気の意義." 耳鼻臨床. 87. 735-746 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 高橋晴雄,他: "笑気ガスによる中耳ガス交換能評価の試み." 耳鼻臨床. 87. 885-889 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 藤田明彦,他: "難治性浸出性中耳炎に対するCAM少量長期投与の効果." 耳鼻臨床. 87. 1287-1291 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Takahashi H, et al: "Assessment of gas exchange function of middle ear using nitrous oxide-a preliminary study." Acta Otolayngol(Stockh). 114. 643-646 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 藤田明彦,他: "難治性浸出性中耳炎と中耳真珠腫." 耳鼻臨床. 87. 755-759 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Takahashi H,et al: "Eustachian tube compliance in cleft palate-a preliminary sutdy." Laryngoscope. 104. 83-86 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 高橋晴彦,他: "滲出性中耳炎に対する耳管通気の意義." 耳鼻臨床. 87. 735-746 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 高橋晴彦,他: "笑気ガスによる中耳ガス交換能評価の試み." 耳鼻臨床. 87. 885-889 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 高橋晴彦,他: "難治性滲出性中耳炎に対するCAM少量長期投与の効果." 耳鼻臨床. 87. 1287-1291 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Takahashi H,et al: "Assessment of gas exchange function of middle esr using nitrous oxide-a preliminary study." Acta Otolayngol(Stockh). 114. 643-646 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 藤田明彦,他: "難治性滲出性中耳炎と中耳真珠腫." 耳鼻臨床. 87. 755-759 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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