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A role of herpes simplex virus infection in the pathogenesis of Bell's palsy

Research Project

Project/Area Number 06454488
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionEhime University

Principal Investigator

YANAGIHARA Naoaki  Ehime University, Otolaryngology, Professor, 医学部, 教授 (40025581)

Co-Investigator(Kenkyū-buntansha) HINOHIRA Yasuyuki  Ehime University, Otolaryngology, Assistant Professor, 医学部, 助手 (00238320)
MURAKAMI Shingo  Ehime University, Otolaryngology, Assistant Professor, 医学部・附属病院, 講師 (80157750)
YUMOTO Eiji  Ehime University, Otolaryngology, Assistant Professor, 医学部・附属病院, 講師 (40116992)
GYO Kiyofumi  Ehime University, Otolaryngology, Associate Professor, 医学部, 助教授 (00108383)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1994: ¥6,000,000 (Direct Cost: ¥6,000,000)
KeywordsBell's palsy / facial nerve paralysis / herpes simplex virus / PCR / mouse / immunological aspects / 顔面神経 / 潜伏感染 / 中和抗体
Research Abstract

Herpes simplex virus type 1 (HSV-1) is a neurotropic virus primary infection with which subsides to latency in the sensory ganglia after recovery. Latent HSV-1 infection and its reactivation in the geniculate ganglion of the facial nerve have been strongly suggested as a cause of the idiopathic facial nerve paralysis known as Bell's palsy. We have succeeded in detecting HSV-1 genomes in the clinical samples of endoneurial fluid or posterior auricle muscle obtained during decompression surgery of Bell's palsy patients used by polymerase chain reaction (PCR). However, the pathomechanism of facial nerve paralysis remains unclear.
The purpose of this experimantal study was to clarify the immunological aspects to facial nerve paralysis due to HSV-1 infection in a mouse model system. Passive transfer of either anti-HSV-1 antibody or HSV-1 immunized splenic T cells into 4-week-old mice 3 hr after HSV-1 inoculation prevented development of facial nerve paralysis and death, whereas such transfers 48 hr or 96 hr after HSV-1 inoculation did not prevent or exacerbate facial nerve paralysis. These results demonstrated that the age and the immunological potency of mice are closely related to the pathogenesis of facial nerve paralysis. The results of T cell passive immunization tests suggested that autoimmune demyelination is unlikely as a cause of facial nerve paralysis in this model.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] Murakami S: "Histopathology of Facial Nerve Neuritis Caused by Herpes Simplex Virus Infection in Mice." Eur Arch Otorhinolaryngology. Suppl. 487-488 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Sugita T: "Facial nerve paralysis induced by herpes simplex virus infection in mice." Eur Arch Otorhinolaryngology. Suppl. 503-503 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Sugita T: "Facial nerve paralysis induced by herpes simplex virus in mice, ananimal model of acute and transient facial paralysis." Ann Otol Rhinol Lryngol. 104. 574-81 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Murkami S: "Bell pasy and herpes simplex virus : Identification of viral DNA in endoneural fluid and muscle." Ann Intern Med. 124. 27-30 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Murkami S: "A role of herpes simplex virus infection in the pathogenesis of facial paralysis in mice." Ann Otol Rhinol Laryngol. 105. 49-53 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Murakami S,Sugita T,Hirata Y,Yanagihara N,Desaki J.: "Histopathology of Facial Nerve Neuritis Caused by Herpes Simplex Virus Infection in Mice." Eur Arch Otorhinolaryngology. Suppl. 487-488 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Sugita T,Murakami S,Hirata Y,Fujiwara Y,Yanagihara N: "Facial nerve paralysis induced by herpes simplex virus infection in mice." Eur Arch Otorhinolaryngology. Suppl. 503 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Sugita T,Murakami S,Yanagihara N,Fujiwara Y,Hirata Y: "Facial nerve paralysis induced by herpes simplex virus in mice, an animal model of acute and transient facial paralysis." Ann Otol Rhinol Laryngol. 104. 574-81 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Murakami S,Mizobuchi M,Nakashiro Y,Doi T,Hato N,Yanagihara N: "Bell pasy and herpes simplex virus : identification of viral DNA in endoneural fluid and muscle." Ann Intern Med. 124. 27-30 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Murakami S,Hato N,Mizobuchi M,Doi T,Yanagihara N: "A role of herpes simplex virus infection in the pathogenesis of facial paralysis in mice." Ann Otol Rhinol Laryngol. 105. 49-53 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Murakami S: "Histopathology of Facial Nerve Neuritis Caused by Herpes Simlex Virus Infection in Mice." Eur Arch Otorhinolaryngology. Suppl. 487-488 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Sugita T: "Facial nerve paralysis induced by herpes simplex virus infection in mice." Eur Arch Otorhinolaryngology. Suppl. 503-503 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Sugita T: "Facial nerve paralysis induced by herpes simplex virus in mice,an animal model of acute and transient facial paralysis." Ann Otol Rhinol Laryngol. 104. 574-81 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Murakami S: "Bell pasy and herpes simplex virus : identification of viral DNA in endoneural fluid and muscle." Ann Intern Med. 124. 27-30 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Murakami S: "A role of herpes simplex virus infection in the pathogenesis of facial paralysis in mice." Ann Otol Rhinol Laryngol. 105. 49-53 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 柳原尚明: "小児の顔面神経麻痺の特徴-臨床統計的観察-" 小児耳鼻咽喉科. 15. 25-27 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 柳原尚明: "HIV感染者に発生した顔面神経麻痺" Facial N.Res.JPN. 14. 125-128 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 村上信五: "Hunt症候群におけるvaricella-zoster virusの検出" Facial N.Res.JPN. 14. 141-144 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 杉田俊明: "ウイルス性顔面神経麻痺動物モデルの組織学的研究" Facial N.Res.JPN. 14. 17-20 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 羽藤直人: "HSV顔面神経麻痺モデルにおける抗体価の変動" Facial N.Res.JPN. 14. 25-28 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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