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Circadian rhythms in bone resorption and the effects of blockers of bone resorption

Research Project

Project/Area Number 06454518
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Functional basic dentistry
Research InstitutionTohoku University

Principal Investigator

SHINODA Hisashi  Tohoku Univ. Sch. Dent., 医学部, 教授 (80014025)

Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥7,000,000 (Direct Cost: ¥7,000,000)
Fiscal Year 1995: ¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1994: ¥4,400,000 (Direct Cost: ¥4,400,000)
KeywordsCircadian / rhythm / calcitonin / bisphosphonate / bone / resorption / chronopharmacology / diurnal / 骨代謝 / 薬効 / エストロジェン
Research Abstract

In the present study, the significance of the diurnal fluctuation of Ca metabolism, especially of the bone resorbing activity in rats, was discussed in relation to the administration of blockers of bone resorption. Under physiological condition, serum Ca, Ca transfer into bone and Ca release from bone followed diurnal rhythms in rats. The magnitude of the effects of blockers of bone resorption also varied diurnally depending on the time of drug administration, which indicates that the sensitivity of the target site (bone resorption process) to the drug also varied diurnally. Thus, it appears that if a blocker of bone resorption is administered during active bone resorption, it has a large effect, and if it is given during a period of less active bone resorption, its effect is diminished. In the field of Ca metabolism, the timing of drug administration or experimental method has thus far been based more frequently on the traditional homeostatic hypothesis. The homeostatic hypothesis implies that the pharmacological and toxicological effects of chemical agents are uniform, and are independing of the timing of administration. However, the studies described here have shown that this hypothesis may be invarid or inappropriate. The present findings should prove to be important not only in future experimental design and in the interpretation of experimental data, but also in the efficacious use of drugs which affect bone resorption.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] H.Shinoda: "Diurnal rhythm in calcium metabolism in rats and their relations to the effect of blockers of bone resorption." Pharmacological Approach to the study of the Farmation and Resorption mechanism of Hard Tissues. (-). 43-55 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.Ohtsuka,H.Shinoda: "Ontogeny of circadian dentinogenesis in rats." Archives of oral Biology. 40. 481-485 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] P.Lakatos,A.Blumshon,R.Eastell,G.Tarjan,H.Shinoda,P.H.Stern: "Circadian rhythm of bone-resorling activity in human serum." Journal of Clinical Endocrinology and Metabolism. 80. 3185-3190 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 篠田壽: "ビスホスホネートの骨吸収抑制作用" 日本薬理学雑誌. 105. 285-294 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 篠田壽,荘司佳奈子,鈴藤勝巳: "小動物骨塩量の簡易測定法" 東北大学歯学会雑誌. 13. 122-129 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 大塚美重,篠田壽: "生体リズムを記録する歯の成長線" 細胞. 28. 20-25 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] H.Shinoda: "Diurnal rhythms in calcium metabolism in rats and their relations to the effect of blockers of bone resorption." In : Pharmacological Approach to the Study of the Formation and the Resorption Mechanisms of Hard Tissues (ed. H.Ogura), Ishiyaku EuroAmerica, Tokyo, St. Louis. 43-55 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] H.Shinoda: "Simmple and rapid determination of bone mineral content in small experimental animals." Tohoku University Dental Journal. 13 (2). 122-129 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.Ohtsuka, H.Shinoda: "Ontogeny of circadian dentinogenesis in rats." Archives of Oral Biology. 40 (6). 481-485 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] P.Lakatos, A.Blumsohn, R.Eastell, G.Tarjan, Shinoda, P.H.Stern: "Circadian rhythm of bone-resorbing activity in human serum." Journal of Clinical Endocrinology and Metabolism. 80 (11). 3185-3190 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] H.Shinoda: "Inhibitory effects of bisphosphonates on bone resorption" Folia Pharmacologica Japonica. 105 (2). 285-294 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.Ohtsuka, H.Shinoda: "Biological rhythms in teeth : Ontogeny of circadian rhythms of dentinogenesis." The cell. 28 (3). 104-109 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] M.Ohtsuka,H.Shinoda: "Ontogeny of circadiandentinogenesis in rats." Archines of oral Biol. 40. 481-485 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 篠田壽: "ビスホスホネートの骨吸収抑制作用" 日本薬理学雑誌. 105. 285-294 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] P.Lakafos,A.Blumsohn,R.Eastell,G.Tarjan,H.Shinoda,P.M.Stern: "Circadian rhythm of bone-resorbing activity in human serum" Journal of Clinical Endocrinology and Metabolism. 80. 3185-3190 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 篠田寿,荘司佳奈子,鈴藤勝巳: "小動物骨塩量の簡易測定法" 東北大学歯学会雑誌. 13. 122-129 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 大塚美重,篠田壽: "生体リズムを記録する歯の成長線" 細胞. 28. 20-25 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Mie Ohtsuka: "Ontogeny of circadian dentinogenesis in rats." Archives of oral Biology. (in press). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 篠田 壽: "Bisphosphonatesの骨吸収抑制作用" 日本薬理学雑誌. (印刷中). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kanako Shoji: "Inhibitory effects of a bisphosphonate,risedronate on alveolar bone resorption in rats." Journal of Periodontal Research. (印刷中). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 篠田 壽: "小動物骨塩量の簡易測定法" 東北大学歯学雑誌. 13. 122-129 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] H.Shinoda: "Pharmacolagical Approach to the study of the Formation and the Resorption Mechanisms of Hard Tissues" Ishiyaku EuroAmerica, 186 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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