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Development of Antibacterial and Deodorant Denture

Research Project

Project/Area Number 06454554
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 補綴理工系歯学
Research InstitutionOsaka University

Principal Investigator

TERAOKA Fumio  Osaka Univ.Fac.of Dent.Assist., 歯学部, 助手 (00099805)

Co-Investigator(Kenkyū-buntansha) ONO Takahiro  Osaka Univ.Fac.of Dent.Assoc.Prof., 歯学部・附属病院, 講師 (30204241)
SOUMURA Taiji  Osaka Univ.Fac.of Dent.Assoc.Prof., 歯学部, 講師 (10154692)
OKAZAKI Masayuki  Osaka Univ.Fac.of Dent.Assoc.Prof., 歯学部, 助教授 (30107073)
TAKAHASHI Junzo  Osaka Univ.Fac.of Dent.Prof., 歯学部, 教授 (80029149)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 1995: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1994: ¥2,600,000 (Direct Cost: ¥2,600,000)
KeywordsBamboo extract / Candida albicans / antibacterial activity / MIC / Tissue conditioner / Base resin / 抗菌・殺菌性 / ティッシュコンディショナ / C.albicans / 消臭作用 / 有床義歯 / ティッシュコンディショナ- / 軟質裏装材 / Staphylococcus aureus / Stretococcus mutans / Candida alficans
Research Abstract

This study investigated bamboo extract, which was distillled at 200゚C under a reduced pressure of 20 mm Hg, as an autibacterial agent or disinfectant for dental use. Antibacterial and bactericidal activities of the bamboo extract against Staphylococcus aureus (S.aureus), Streptococcus mutans (S.mutans) and Candida albicans (C.albicans) were examined by measuring MIC (minimum inhibitory concentration) and MBC (minimum bactericidal concentration), respectively. The MIC of the bamboo extract was 2.5% against C.albicans. The bactericidal activity was confirmed by MBC,which was nearly equal to the MIC,against these microorganism. The 5% bamboo extract exhibited a marked antibacterial and bactericidal activity against these microorganiam. The bamboo extract contained more than 40 components, which were mainly Furans or Phenols. All of the mice were in normal health before and after the toxicity tests. These results suggest that the bamboo extract can be used safely as an antibacterial agent or disinfectant comparable to conventional compounds used for those purpose.
Antibacterial activity of tissue conditioners and dentures containing bamboo extract on Candida albicans was investigated. Then the effects of bamboo extract on the attachment of Candida albicans on tissue conditioners and dentures were studied in vitro and in vivo. When tissue conditioners containing bamboo extract were immersed in Heart infusion (HI) agar medium, the bamboo extract scacely eluted. The adhesion of Candida albicans on tissue conditioners containing 10 wt% bamboo extract was significantly inhibited.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] 寺岡文雄 ほか1名: "竹エキスの抗菌性と歯科への応用に関する研究 第1報 竹エキス濃度と抗菌性との関係" 歯科材料・器械. 14. 219-224 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 寺岡文雄 ほか2名: "竹エキスの抗菌性と歯科への応用に関する研究 第2報 ティシュコンディショナへの応用" 歯科材料・器械. 15. 146-149 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] F.Teraoka and J.Takahashi: "Antibacterial Activity of Bamboo Extract and its Application in Clinical Dentistry (Part 1) Reiationship between Concentration of Bamboo Extract and Antibacterial Activity" The Journal of the Japanese Society for Dental Materials and Devices. vol.14, No.2. 219-224 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] F.Teraoka, K.Kitahara and J.Takahashi: "Antibacterial Activity of Bamboo Extract and its Application in Clinical Dentistry (Part 2) Applications of Bamboo Extract or Tissue Conditioner" The Journal of the Japanese Society for Dental Materials and Devices. vol.15, No.2. 146-149 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 寺岡文雄他1名: "竹エキスの抗菌性と歯科への応用に関する研究 第1報 竹エキス濃度と抗菌性との関係" 歯科材料・器械. 14. 219-224 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 寺岡文雄他2名: "竹エキスの抗菌性と歯科への応用に関する研究 第2報 ティッシュコンディショナへの応用" 歯科材料・器械. 15. 146-149 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 寺岡文雄他1名: "竹エキスの抗菌性と歯科への応用に関する研究 第1報 竹エキス濃度と抗菌性との関係" 歯科材料・器械. 14(2). 219-224 (1995)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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