| Project/Area Number |
06454554
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
補綴理工系歯学
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| Research Institution | Osaka University |
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Principal Investigator |
TERAOKA Fumio Osaka Univ.Fac.of Dent.Assist., 歯学部, 助手 (00099805)
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| Co-Investigator(Kenkyū-buntansha) |
ONO Takahiro Osaka Univ.Fac.of Dent.Assoc.Prof., 歯学部・附属病院, 講師 (30204241)
SOUMURA Taiji Osaka Univ.Fac.of Dent.Assoc.Prof., 歯学部, 講師 (10154692)
OKAZAKI Masayuki Osaka Univ.Fac.of Dent.Assoc.Prof., 歯学部, 助教授 (30107073)
TAKAHASHI Junzo Osaka Univ.Fac.of Dent.Prof., 歯学部, 教授 (80029149)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 1995: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1994: ¥2,600,000 (Direct Cost: ¥2,600,000)
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| Keywords | Bamboo extract / Candida albicans / antibacterial activity / MIC / Tissue conditioner / Base resin / 抗菌・殺菌性 / ティッシュコンディショナ / C.albicans / 消臭作用 / 有床義歯 / ティッシュコンディショナ- / 軟質裏装材 / Staphylococcus aureus / Stretococcus mutans / Candida alficans |
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| Research Abstract |
This study investigated bamboo extract, which was distillled at 200ﾟC under a reduced pressure of 20 mm Hg, as an autibacterial agent or disinfectant for dental use. Antibacterial and bactericidal activities of the bamboo extract against Staphylococcus aureus (S.aureus), Streptococcus mutans (S.mutans) and Candida albicans (C.albicans) were examined by measuring MIC (minimum inhibitory concentration) and MBC (minimum bactericidal concentration), respectively. The MIC of the bamboo extract was 2.5% against C.albicans. The bactericidal activity was confirmed by MBC,which was nearly equal to the MIC,against these microorganism. The 5% bamboo extract exhibited a marked antibacterial and bactericidal activity against these microorganiam. The bamboo extract contained more than 40 components, which were mainly Furans or Phenols. All of the mice were in normal health before and after the toxicity tests. These results suggest that the bamboo extract can be used safely as an antibacterial agent or disinfectant comparable to conventional compounds used for those purpose.
Antibacterial activity of tissue conditioners and dentures containing bamboo extract on Candida albicans was investigated. Then the effects of bamboo extract on the attachment of Candida albicans on tissue conditioners and dentures were studied in vitro and in vivo. When tissue conditioners containing bamboo extract were immersed in Heart infusion (HI) agar medium, the bamboo extract scacely eluted. The adhesion of Candida albicans on tissue conditioners containing 10 wt% bamboo extract was significantly inhibited.
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