| Project/Area Number |
06454573
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | TOKYO DENTAL COLLEGE |
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Principal Investigator |
KANEKO Yuzuru Tokyo Dental College, Dentistry, Professor, 歯学部, 教授 (00085747)
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| Co-Investigator(Kenkyū-buntansha) |
SAKURAI Makoto Tokyo Dental College, Dentistry, Assistant Professor, 歯学部, 講師 (40215687)
SUGIYAMA Ayako Tokyo Dental College, Dentistry, Assistant Professor, 歯学部, 講師 (80171180)
ICHONOHE Tatsuya Tokyo Dental College, Dentistry, Associate Professor, 歯学部, 助教授 (40184626)
五十嵐 治 東京歯科大学, 歯学部, 講師 (30246334)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1994: ¥4,700,000 (Direct Cost: ¥4,700,000)
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| Keywords | Inhalation anesthesia / Block analgesia / Surgical stress / Stress free |
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| Research Abstract |
Purpose
To investigate 1) whether block analgesia of maxillary and/or mandibular nerve can mitigate surgical stress during oral surgary and 2) whenther successful block analgesia can reduce anesthetic requirement during oral surgery.
Methods
-Consenting oral surgical patients classified in ASA status-1
-Randomly divided in two groups ; Control group (without block analgesia)
Block group (with block analgesia)
-Anesthetized with nitrous oxide (60%), oxygen (40%) and isoflurane
-Total minimum alveolar concentration (MAC) adjusted to 1.6 MAC in the Control group and 1.0 or 1.3 MAC in the Block group
-Deliberate hypotension with adenosine triphosphate (ATP) in some patients
-Measurements
Heart rate, Blood pressure, Respiratory rate, Blood gas analysis, Plasma catecholamine level, Quantitative assessment of hemodynamic changes
Results and Conclusions
1. Successful block analgesia could cause hemodynamic, respiratory and endocrinic stability during oral surgery in the Block group.
2. Less hemodynamic and respiratory inhibition was observed in the Block group.
3. Successful block analgesia reduced ATP requirement for deliberate hypotension in the Block group.
4. Successful block analgesia reduced anesthetic requirement in the Block group.
5. It is suggested that the block analgesia can reduce surgical and anesthesia stress during oral surgery.
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