| Budget Amount *help |
¥6,700,000 (Direct Cost: ¥6,700,000)
Fiscal Year 1995: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1994: ¥3,600,000 (Direct Cost: ¥3,600,000)
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| Research Abstract |
The fibroblast growth factor (FGF) receptor family consists of four members, FGFR-1, FGFR-2, FGFR-3 and FGFR-4, that are closely related receptor tyrosine kinases. We examined the expression of mRNAs for four members of rat FGF receptor family in the brain. The FGFR-1, FGFR-2, FGFR-3 mRNAs were widely but differentially expressed in the brain. However, the FGFR-4 mRNA was preferentially expressed in very small discrete regions in the epithalamus. The FGFR-1 mRNA was strongly expressed in several regions including the hippocampus, cerebellum and pedunculopotine tegmental nucleus. The FGFR-2 mRNA expression was high in the choroid plexus, and moderate in the fiber-rich regions (the corpus callosum, external capsule and internal capsule). The FGFR-3 mRNA was diffusely expressed in the brain. In contrast, the FGFR-4 was preferentially expressed in the medial habenular nucleus. We also examined cellular localization of these mRNAs in the brain. Although the FGFR-1 mRNA was preferentially expressed in neurons, the FGFR-2 and FGFR-3 mRNAs were preferentially expressed in oligodendrocytes and astrocytes, respectively. The FGFR-4 mRNA was preferentially in cholinergic neurons. These findings that indicate that these receptors have different roles in the brain.
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