| Project/Area Number |
06454656
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | Faculty of Pharmaceutical Sciences, The University of Tokushima |
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Principal Investigator |
HIGUTI Tomihiko Pharmaceutical Sciences The University of Tokushima Professor, 薬学部, 教授 (50035557)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 1995: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1994: ¥3,600,000 (Direct Cost: ¥3,600,000)
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| Keywords | ATP synthase / subunit b / transcriptional regulation / Aging / enhancer / biogenesis / mitochondria / 形態形成 / ヒト遺伝子 / subunit b遺伝子 / Sp1 / BTEB / エンハンサー45K / エンハンサー70K |
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| Research Abstract |
We have obtained the following three important scientific findings.
1. The stoichiometry of mRNAs of ATP synthase in rat tissues determined with synthesized mRNAs and probe cDNAs
2. Similarlity of the transcriptional regulation system of subunit b and e genes of ATP synthase
3. Novel nuclear proteins bound to the enhancer cis-element in the first intron of subunit b gene
1) Four kinds of nuclear proteins were bound to the enhancer cis-element in the first intron of subunit b gene : Sp1, BTEB,and novel 45kD and 70kD nuclear proteins.
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