• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Self-Organization of Polymorphic Circuits in Cultured Neural Networks

Research Project

Project/Area Number 06454660
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Biophysics
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

YANO Masafumi  Tohoku University Research Institute of Electrical Communication, 電気通信研究所, 教授 (80119635)

Co-Investigator(Kenkyū-buntansha) MAKINO Yoshinari  Tohoku University Research Institute of Electrical Communication, 電気通信研究所, 助手 (90250844)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥4,900,000 (Direct Cost: ¥4,900,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1994: ¥4,100,000 (Direct Cost: ¥4,100,000)
KeywordsNeural Network / Polymorphic Circuit / Monoamines / Information Processing in Brain
Research Abstract

In general, an anatomical neural network in sensory and motor systems subserves various functions of information processing. This is so-called "polymorphic" network concept. A polymorphic network is a network embedded with multiple circuits which are defined by functional interactions between neurons. For undersatanding the function of the brain such as sensory perception, motor control, learning or memory, it is very important to clarify emerging principles of the polymorphic circuits. In this research, we have made physiological and modeling studies about the self-organization of the polymorphic circuits, and obtained following results.
1. Using a KYS oscillator as a neural element, we modeled a central pattern generator (CPG) of the motor system. The polymorphic property of the CPG could be emerged by controlling intrinsic neural property such as postinhibitory rebound and resting membrane potential, without changing synaptic connectivity.
2. Isolated olfactory network of slug's CNS showed polymorphic property by perfusing biogenic monoamines in extracellular solution. This suggested that monoamines play important roles in emerging the polymorphic property of a biological sensory networks.
3. In biological systems, monoamines change intrinsic neural properties through the intracellular Ca^<++>. Therefore we studied a network-dynamics of the intracellular Ca^<++> with computational simulation, and demonstrated that global Ca^<++> patterns in a network could be emerged according to various external conditions.
These results suggest how the polymorphic property is controlled in biological network, and might provide a new insight into rules for neural network operation.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] Kawahara,S.et al: "Radular mechanosensory neuron in the buccal ganglia of the terrestrial slug,Incilaria fruhstorferi" J Comp Physiol A. 174. 111-120 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tanaka M.et.al.: "Observation of highly organizeddevelopment of graunle cells in rat cerebeller organotypic cultures." Brain Research. 641. 319-327 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kimura,S.et al: "A self-organization model of walking patterns of insect II.The loading effect and leg amputation" Biol Cybern. 70. 505-512 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tanaka M.et.al.: "Effects of endogeneous nitric oxide on the cerebeller cortical development in slice cultures." Neuroreport. 5. 2049-2052 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kawahara,S.et al: "Modulation of the feeding system by a radular mechanosensory neuron in the terrestrial slug,Incilaria fruhstoeferi" J Comp Physiol A. 176. 193-203 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kawahara, S.et al: "Redular Mechanosensory Neuron in the Buccal Ganglia of the Terrestrial Slug, Incilaria Fruhstorferi" J Comp Physiol A. 174. 111-120 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tanaka, M.et al: "Observation of the highly organized development of granule cells in rat cerebellar organotypic cultures" Brain Research. 641. 319-327 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kimura, S.et al: "A self-Organizing model of Walking Patterns of Insect II.The loading effect and leg amputation" Biol Cybern. 70. 505-512 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tanaka, M.et al: "Effects of endogeneous nitric oxide on the cerebellar cortical development in slice cultures" Neuroreport. 5. 2049-2052 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kawahara, S.et al: "Modulation of the feeding system by a radular mechanosensory neuron in the terrestrial slug, Incilaria fruhstorferi" J Comp Physiol A. 176. 193-203 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kawahara,S.et al.: "Modulation of the feeding system by a radular mechanosensory neuron in the terrestrial slug,Incilaria fruhstorferi" J Comp Physiol A. 176. 193-203 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Tanaka M.et.al.: "Observation of highly organized development of granule cells in rat cerebeller organotypic cultures." Brain Research. 641. 319-327 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Tanaka M.et.al.: "Effects of endogeneous nitric oxide on the cerebeller cortical development in slice cultures." Neuroreport. 5. 2049-2052 (1994)

    • Related Report
      1994 Annual Research Report

URL: 

Published: 1994-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi