| Project/Area Number |
06454681
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Tokyo Metropolitan Institute of Gerontology (TMIG) |
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Principal Investigator |
INAGAKI Masaki Tokyo Metropolitan Institute of Gerontology, Dept., Neurophysiology, Head., 神経生理部門, 研究室長 (30183007)
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| Co-Investigator(Kenkyū-buntansha) |
SEKIMATA Masayuki Tokyo Metropolitan Institute of Gerontology, Dept., Neurophysiology, Research Re, 神経生理部門, 研究員 (80250190)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥6,100,000 (Direct Cost: ¥6,100,000)
Fiscal Year 1995: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1994: ¥4,200,000 (Direct Cost: ¥4,200,000)
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| Keywords | Intermediate Filament / Function / Phosphorylation / Protein Kinases / Visualization / Dynamic Property |
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| Research Abstract |
Site-specific phosphory lation of intermediate filament (IF) proteins on serine and threoninc residues leads to alteration of the filament structure, in vitro and in vivo, Protein kinases involved in cell signaling and those activated in mitosis dynamically control spatial and temporal organization of intracellular IF phosphorylation.Thus, IF phosphorylation appears to be one of the most predominant stratogy to coordinate intracellular organization of the IF network.
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