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Analysis of homeostatic responses to stressful environments using molecular techniques.

Research Project

Project/Area Number 06557006
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section試験
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

HORI Tetsuro  Kyushu University, Faculty of Medicine Professor, 医学部, 教授 (00022814)

Co-Investigator(Kenkyū-buntansha) TAKE Sachiko  Kyushu University, Faculty of Medicine Assistant Professor, 医学部, 助手 (80253425)
TAKAKI Atsushi  Kyushu University, Faculty of Medicine Assistant Professor, 医学部, 助手 (30243934)
KATAFUCHI Toshihiko  Kyushu University, Faculty of Medicine Assistant Professor, 医学部, 講師 (80177401)
AOU Shuji  Kyushu University, Faculty of Medicine Associate Professor, 医学部, 助教授 (40150908)
大島 靖美  九州大学, 理学部, 教授 (90037606)
上野 光  九州大学, 医学部, 講師 (50260378)
Project Period (FY) 1994 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥17,600,000 (Direct Cost: ¥17,600,000)
Fiscal Year 1996: ¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 1995: ¥5,400,000 (Direct Cost: ¥5,400,000)
Fiscal Year 1994: ¥8,000,000 (Direct Cost: ¥8,000,000)
Keywordsnon-RI in situ hybridization / antisense oligodeoxynucleotide / Morris water maze / hippocampus / c-kit mutant rat / LTP / c-fos / heat exposure / ミュータントラット / paired pulse fancilitation / 暑熱暴露 / 拘束ストレス / インターロイキン-6 / 肝臓交感神経 / 海馬 / モリス水迷路 / mRNA / 非放射性cDNAプローブ / HRP法 / 発熱 / IL-1β / 脾臓マクロファージ
Research Abstract

(1) We estabalished a new and reproducible in situ hybridization technique using non-RI antisense DNA probes designed by aymmetric polymerase chain reaction and thymine dimer method. Using this technique, we revealed that high amount of IL-1betamRNA was expressed in rat splenic macrophages in responses to systemic injection of lipopolysaccharide.
(2) We synthesized an 18-mer oligodeoxynucleotide complementary to the translation initiation site of calcineurin AalphamRNA to inhibit the expression of calcineurin Aalpha and analyzed its effect on the spatial learning and memory. Injections of the antisense oligo-DNA into the bilateral hippocampus in rats resulted in a slight reduction of time required for platform finding in Morris water maze compared with animals injected with saline, although the difference was not statistically significant.
(3) Homozygous mutant rats with deficits in four aminoacids located near the tyrosine autophosphorylation site of c-kit tyrosine kinase receptor showe … More d an impaired spatial learning when tested in the Morris water maze, whereas activity and motor abilities appeared normal. In the next experiment, extracellular field potentials were recorded in areas CA1 and CA3 of the hippocampal slice preparation following stimulation of the Schaffer-commissural pathway and mossy fiber layr in the dentate gyrus, respectively. Presynaptically mediated forms of synaptic potentiation, paired-pulse facilitation of the c-kit mutant rats significantly reduced both in CA1 and CA3 region compared with+/+control rats. In addition, the mutant rats are also deficient in long-term potentiation after tetanic stimulation in CA3 region. These observations suggested a role for kit signialing in the adult central nervous system.
(4) We synthesized an 15-mer oligodeoxynucleotide complementary to the translation initiation site of c-fos mRNA to analyze roles of Fos protein in thermoregulation. When the antisense oligo-DNA was injected into the bilataral medial proptic nucleus (MPO) in rats, rectal temperatures during heat exposure were significantly lower than those in control rats injected with sense oligo-DNA.The dose of the antisense oligo-DNA was sufficient to block the expression of Fos protein in the MPO. Less

Report

(4 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • 1994 Annual Research Report
  • Research Products

    (194 results)

All Other

All Publications (194 results)

  • [Publications] Ma,J.: "Hypothalamic stimulation induces vagally mediated hypocalcemia in the rat." Brain Res. Bull.33. 65-69 (1994)

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      1996 Final Research Report Summary
  • [Publications] Shimizu,N.: "An IL-1 β induced noradrenaline release in the spleen is mediatedby brain corticotropin-releasing factor : an in vivo microdialysis study with conscious rats." Brain,Behavior & Immunity. 7. 14-23 (1994)

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  • [Publications] Szreder,Z.: "Thermoregulatory effect of intracerebral injections of neuropeptide Y in rats at different environmental temperatures." Gen.Pharmac.25. 85-91 (1994)

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  • [Publications] Ma,J.: "Linkage of stress-induced hypocalcemia,gastric lesions and emotional behavior in Wistar Kyoto rats." Am.J.Physiol.266. R960-R965 (1994)

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  • [Publications] Kuroda,Y.: "Restraint stress suppresses experimental allergic encephalomyelitis in Lewis rats." Brain Res.Bull.34. 15-17 (1994)

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  • [Publications] Ma,J.: "Ventromedial hypothalamus mediates stress-induced hypocalcemia via the gastric vagus in rats." Brain Rec.Bull.34. 41-45 (1994)

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  • [Publications] Aou,S.: "The effect of B-HT920,a dopamine D2 agonist,on bar-press feeding in the monkey." Physiol.Behav.55. 1125-1130 (1994)

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  • [Publications] Ichijo,T.: "Central interleukin-1 β enhances splenic sympathetic nerve activity in rats." Brain Res.Bull.34. 547-553 (1994)

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      1996 Final Research Report Summary
  • [Publications] Katafuchi,T.: "The biphasic changes in splenic natural killer cell activity following ventromedial hypothalamic lesions in rats." Brain Res.652. 164-168 (1994)

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  • [Publications] Oka,T.: "EP1-receptor mediation of prostaglandin E2-induced hyperthermia in rats." Am.J.Physiol.267. R289-R294 (1994)

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      1996 Final Research Report Summary
  • [Publications] Shimizu,N.: "CRF receptor antagonist attenuates stress-induced noradrenaline release in the medial prefrontal cortex of rats." Brain Res.654. 145-148 (1994)

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      1996 Final Research Report Summary
  • [Publications] Oka,T.: "Intracerebroventricular injection of interleukin-1 β enhances nociceptive neuronal responses of the trigeminal nucleus caudalis in rats." Brain Res.656. 236-244 (1994)

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      1996 Final Research Report Summary
  • [Publications] Oka,T.: "Intracerebroventricular injection of prostaglandin E2 induces thermal hyperalgesia in rats : the possible involvement of EP3 receptors." Brain Res.663. 287-292 (1994)

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      1996 Final Research Report Summary
  • [Publications] Aou,S.: "Hypothalamic linkage in stress-induced hypocalcemia,gastric damage,and emotional behavior in rats." Am.J.Physiol.267. R38-R43 (1994)

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      1996 Final Research Report Summary
  • [Publications] Kanemitsu,Y.: "Production of antisense DNA probe by asymmetric PCR and its application to in situ hybridization." Nucleic Acids Symposium Series. 31. 57-59 (1994)

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      1996 Final Research Report Summary
  • [Publications] Nakane,H.: "Stress-indcued noradrenaline release in the rat prefrontal cortex measured by microdialysis." Am.J.Physiol.267. R1559-R1566 (1994)

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      1996 Final Research Report Summary
  • [Publications] Sasaki,K.: "Effects of fibroblast growth factors and related peptides on food intake by rats." Physiol.Behav.56. 211-218 (1994)

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  • [Publications] Matsui,H.: "The central action of parathyroid hormone on blood calcium and hypothalamic neuronal activity in the rat." Am.J.physiol.268. R21-R27 (1995)

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  • [Publications] Nakashima,T.: "Naloxone suppresses the rising phase of fever induced by interferon α." Brain Res.Bull.37. 61-66 (1995)

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      1996 Final Research Report Summary
  • [Publications] Take,S: "Interferon-α acts at the preoptic hypothalamus to reduce natural killer cytotoxicity in rats." Am.J.physiol.268. R1406-R1410 (1995)

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      1996 Final Research Report Summary
  • [Publications] Niijima,A.: "The effect of interleukin-1 β on the efferent activity of the vagus nerve to the thymus." J.Autonom.Nerv.System. 54. 137-144 (1995)

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  • [Publications] Ando,T.: "Intracerebroventricular injection of prostaglandin E2 increases splenic sympathetic nerve activity in rats." Am.J.Physiol.269. R662-R668 (1995)

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      1996 Final Research Report Summary
  • [Publications] Oka,T.: "Intracerebroventricular injection of interleukin-6 induces thermal hyperalgesia in rats." Brain Res.692. 123-128 (1995)

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      1996 Final Research Report Summary
  • [Publications] Oka,T.: "The opposing effects of interleukin-1 β microinjected into the preoptic hypothalamus and the ventromedial hypothalamus on nociceptive behavior in rats." Brain Res.700. 271-278 (1995)

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  • [Publications] Katafuchi,T.: "Cerebellar afferents to neuroendocrine cells : impliocations for adaptive responses to stimulated weightlessness." Endocrine J.42. 729-737 (1995)

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  • [Publications] Ota,K.: "Responses of the rat ventromedial hypothalamic neuron activity to tumor necrosis factor-α." Body Temperature and Metabolism. 34-36 (1995)

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      1996 Final Research Report Summary
  • [Publications] Katafuchi,T.: "Prostanoids-dependent responses of AV3V neurones to blood-borne IL-1 β : a possible implication in the blood cytokines-brain signal transduction." Body Temperature and Metabolism. 37-40 (1995)

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      1996 Final Research Report Summary
  • [Publications] Oka,T.: "Central prostaglandin E2-induceed fever and hyperalgesia are mediated by different types of EP receptors." Body Temperature and Metabolism. 45-48 (1995)

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      1996 Final Research Report Summary
  • [Publications] Hori,T.: "The autonomic nervous system as a communication channel between the brain and the immune system." Neuroimmunomodulation. 2. 203-215 (1995)

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      1996 Final Research Report Summary
  • [Publications] Hori,T.: "The hypothalamo-sympathetic nervous system modulates peripheral celluar immunity." Neurobiology. 3. 309-318 (1995)

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      1996 Final Research Report Summary
  • [Publications] Aou,S.: "Hypothalamus regulates calcium metabolism in rats." Neurobiology. 3. 339-350 (1995)

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      1996 Final Research Report Summary
  • [Publications] Katafichi,T.: "Roles of cytokines in the neural-immune interactions : modulation of NMDA responses by IFN α." Neurobiology. 3. 319-328 (1995)

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      1996 Final Research Report Summary
  • [Publications] Sasaki,K.: "Actions of acidic fibroblast growth factor fragments on food intake in rats." Obesity Research. 3(Suppl 5). 697S-706S (1995)

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      1996 Final Research Report Summary
  • [Publications] Uchimura,D.: "Facilitatory effects of pituitary adenylate cyclase activating polypeptide (PACAP) on neurons in the magnocellular portion of the rat hypothalamic paraventricular nucleus (PVN) in vitro." J.Neuroendocrinol.8. 137-143 (1996)

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  • [Publications] Li,A-J.: "Fibroblast growth factor receptor-1 in the lateral hypothalamic area regulates food intake." Exptl.Neurol.137. 318-323 (1996)

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  • [Publications] Shimizu,N.: "Immobilization increases noradrenaline release and reduces NK cytotoxicity in spleen of conscious rat." Am.J.Physiol.271. R537-R544 (1996)

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  • [Publications] Mo,Z.L.: "The effects of IL-1 β on neuronal activities in the dorsal motor nucleus of the vagus in rat brain slices." Brain Res. Bull.41. 249-255 (1996)

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  • [Publications] Oka,T.: "Intracerebroventricular injection of tumor necrosis factor α induces thermal hyperalgesia in rats." Neuroimmunomodulation. 3. 135-140 (1996)

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      1996 Final Research Report Summary
  • [Publications] Oka,T.: "Inhibition of peripheral interleukin-1-β-induced hyperalgesia by the intracerebroventricular administration of diclofenac and α-melanocyte-stimulating hormone." Brain Res.736. 237-242 (1996)

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  • [Publications] Oka,K.: "The AV3V neurons which send axons to hypothalamic nuclei respond to the systemic injection of IL-1 β." Am.J.Physiol.(in press). (1997)

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  • [Publications] Oka,T.: "Biphasic alteration in the trigeminal nociceptive neuronal responses after intracerebroventricular injection of prostaglandin E2 in rats." Brain Res.(in press). (1997)

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  • [Publications] Li,A.J.: "Interleukin-6 inhibits long-term potentiation in rat hippocampal slices." Brain Res.(in press). (1997)

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      1996 Final Research Report Summary
  • [Publications] Katafuchi,T.: "Differential effects of tumor necrosis factor-α and-β on the rat ventromedial hypothalamic neurons in vitro." Am.J.Physiol.(in press). (1997)

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      1996 Final Research Report Summary
  • [Publications] 堀哲郎: "神経系と免疫系の対話" 日本臨床. 52. 2843-2849 (1994)

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      1996 Final Research Report Summary
  • [Publications] 片渕俊彦: "生理活性物質の生理学" 臨床検査 増刊号、ホルモンと生理活性物質. 38. 20-24 (1994)

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  • [Publications] 堀哲郎: "脳と免疫系" 日本サイコオンコロジー学会誌. 7. 35-37 (1994)

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  • [Publications] 片渕俊彦: "脳-免疫系連関とサイトカイン" 別冊・医学のあゆみ、免疫疾患-state of arts. 94-97 (1995)

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  • [Publications] 堀哲郎: "脳・免疫系連関からみた発熱" 臨床と研究. 72. 2381-2386 (1995)

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  • [Publications] 粟生修司: "視床下部を中心とする性行動・情動行動制御機構:視床下部機能の新しい側面" 日本生理学雑誌. 57. 155-163 (1995)

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  • [Publications] 堀哲郎: "脳・免疫系連関と発熱" 第24回日本医学会総会「会誌」. 2. 538-539 (1995)

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  • [Publications] 片渕俊彦: "交感神経系を介する免疫調節" 第24回日本医学会総会「会誌」. 3. 72- (1995)

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  • [Publications] 片渕俊彦: "交感神経による脾臓ナチュラルキラー細胞活性制御の視床下部機序" 自立神経. 33. 267-272 (1996)

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  • [Publications] 岡孝和: "痛みと情動" Clinical Neuroscience. 14. 1025-1027 (1996)

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  • [Publications] 堀哲郎: "発熱の病態生理" Today's Therapy. 20. 115-118 (1996)

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  • [Publications] Hori,T.: "Integrative and Cellular Aspects of Autonomic Functions : Temperature and Osmoregulation." John Libbey Eurotext, 554 (1994)

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  • [Publications] Hori,T.: "Recent Advances in Medical Balneology and Climatology" Hokkaido University Medical Library Series, 158 (1995)

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  • [Publications] Hori,T.: "Discussion on Future Directions in Psychoneuroimmunology and Cancer." Nishimura Co.,Ltd.and Smith-Gordon Co.,Ltd., 166 (1996)

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  • [Publications] Hori,T.: "Physiological Basis of Occupational Health : Stressful Environments." SPB Academic Publishing bv, 278 (1996)

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  • [Publications] 片渕俊彦: "第11回「ニューロトランスミッターと疾患研究会」ワークショップ・プロシ-ディングス、神経系と免疫系の相互関連" エクセプタ・メディカ社, 89 (1994)

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  • [Publications] 堀哲郎: "新編・感覚・知覚心理学ハンドブック" 誠信書房, 1741(1196-1203) (1994)

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  • [Publications] 堀哲郎: "新編・感覚・知覚心理学ハンドブック" 誠信書房, 1741(1249-1261) (1994)

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  • [Publications] 堀哲郎: "現代の生理学(改訂第3版)" 金原出版, 1007 (1994)

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  • [Publications] 堀哲郎: "精神活動の流れを遡る-機能・構造・物質-vol.2" メディカル・ジャーナル社, 156 (1994)

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  • [Publications] 堀哲郎: "感染症と生体防御の基本原理-総合的視点を中心として-" 日本細菌学会総会事務局, 135 (1994)

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  • [Publications] 片渕俊彦: "脳機能の解明-分子から病態まで-" 創風社, 286 (1994)

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  • [Publications] 堀哲郎: "脳と免疫" 共立出版, 195(p.1-6) (1994)

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      1996 Final Research Report Summary
  • [Publications] 武幸子: "脳と免疫" 共立出版, 195(27-38) (1994)

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      1996 Final Research Report Summary
  • [Publications] 堀哲郎: "脳と免疫" 共立出版, 195(39-58) (1995)

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      1996 Final Research Report Summary
  • [Publications] 堀哲郎: "脳と免疫" 共立出版, 195(83-108) (1995)

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      1996 Final Research Report Summary
  • [Publications] 堀哲郎: "精神活動の流れを遡る-機能・構造・物質-" メディカル・ジャーナル社, 196 (1995)

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      1996 Final Research Report Summary
  • [Publications] 武幸子: "自律神経機能検査(第2版)" 文光堂, 414 (1995)

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      1996 Final Research Report Summary
  • [Publications] 堀哲郎: "現代病理学大系 補遺1" 中山書店, 261 (1995)

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    • Related Report
      1996 Final Research Report Summary
  • [Publications] 堀哲郎: "現代の神経内分泌学" メディカル・サイエンス・インターナショナル, 506 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 堀哲郎: "最新内科学大系、Part I.内科総論部門、第2巻「科学としての内科学」" 中山書店, 372 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ma, J., Aou, S.& Hori, T.: "Hypothalamic stimulation induces vagally mediated hypocalcemia in the rat." Brain Res.Bull.33. 65-69 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shimizu, N., Hori, T.& Nakane, T.: "An IL-1beta-induced noradrenaline release in the spleen is mediatedby brain corticotropin-releasing factor : an in vivo microdialysis study with conscious rats." Brain, Behavior & Immunity. 7. 14-23 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Szreder, Z., Hori, T.& Kaizuka, Y.: "Thermoregulatory effect of intracerebral injections of neuropeptide Y in rats at different environmental temperatures." Gen.Pharmac.25. 85-91 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ma, J., Aou, S., Hori, T.& Ding.J.: "Linkage of stress-induced hypocalcemia, gastric lesions and emotional behavior in Wistar Kyoto rats." Am.J.Physiol.266. R960-R965 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kuroda, Y., Mori, T.& Hori, T.: "Restraint stress suppresses experimental allergic encephalomyelitis in Lewis rats." Brain Res.Bull.34. 15-17 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ma, J., Aou, S.& Hori, T.: "Ventromedial hypothalamus mediates stress-induced hypocalcemia via the gastric vagus in rats." Brain Res.Bull.34. 41-45 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Aus, S., Mizuno, M., Hori, T.& Yamada, K.: "The effect of B-HT920, a dopamine D2 agonist, on bar-press feeding in the monkey." Physiol.Behav.55. 1125-1130 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ichijo, T., Katafuchi, T.& Hori, T.: "Central interleukin-1beta enhances splenic sympathetic nerve activity in rats." Brain Res.Bull.34. 547-553 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Katafuchi, T., Okada, E., Take, S.& Hori, T.: "The biphasic changes in spenic natural killer cell activity following ventromedial hypothalamic lesions in rats." Brain Res.652. 164-168 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Oka, T.& Hori, T.: "EPI-receptor mediation of prostaglandin E2-induced hyperthermia in rats." Am.J.Physiol.267. R289-R294 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shimizu, N., Nakane, H., Hori, T.& Hayashi, Y.: "CRF receptor antagonist attenuates stress-induced noradrenaline release in the medial prefrontal cortex of rats." Brain Res.654. 145-148 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Oka, T., Aou, S.& Hori, T.: "Intracerebroventricular injection of interleukin-1beta enhances nociceptive neuronal responses of the trigeminal nucleus caudalis in rats." Brain Res.656. 236-244 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Oka, T., Aou, S.& Hori, T.: "Intracerebroventricular injection of prostaglandin E2 induces thermal hyperalgesia in rats : the possible involvement of EP3 receptors." Brain Res.663. 287-292 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Aou, S., Ma, J., Hori, T.& Tashiro, N.: "Hypothalamic linkage in stress-induced hypocalcemia, gastric damage, and emotional behavior in rats." Am.J.Physiol.267. R38-R43 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kanemitsu, Y., Koji, T., Hori, T.& Nakane, P.K.: "Production of antisense DNA probe by asymmetric PCR and its application to in situ hybridization." Nucleic Acids Symposium Series. No.31. 57-59 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nakane, H., Shimizu, N.& Hori, T.: "Stress-indcued noradrenaline release in the rat prefrontal cortex measured by microdialysis." Am.J.Physiol.267. R1559-R1566 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Sasaki, K., Li, A.-J., Oomura, Y., Muto, T., Hanai, K., Tooyama, I., Kimura, H., Yanaihara, N., Yagi, H.& Hori, T.: "Effects of fibroblast growth factors and related peptides on food intake by rats." Physiol.Behav.56. 211-218 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Matsui, H., Aou, S., Ma, J.& Hori, T.: "The central action of parathyroid hormone on blood calcium and hypothalamic neuronal activity in the rat." Am.J.Physiol.268. R21-R27 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Nakashima, T., Murakami, T., Murai, Y., Hori, T.& Kiyohara, T.: "Naloxone suppresses the rising phase of fever induced by interferonalpha." Brain Res.Bull.37. 61-66 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Take, S., Uchimura, D., Kanemitsu, Y., Katafuchi, Y.& Hori, T.: "Interferon-alpha acts at the preoptic hypothalamus to reduce natural killer cytotoxicity in rats." Am.J.Physiol.268. R1406-R1410 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Niijima, A., Hori, T., Katafuchi, T.& Ichijyo, T.: "The effect of interleukin-1beta on the efferent activity of the vagus nerve to the thymus." J.Autonom.Nerv.System.54. 137-144 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ando, T., Ichijyo, t., Katafuchi, T.& Hori, T.: "Intracerebroventricular injection of prostaglandin E2 increases splenic sympathetic nerve activity in rats." Am.J.Physiol.269. R662-R668 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Oka, T., Oka, K., Hosoi, M.& Hori, T.: "Intracerebroventricular injection of interleukin-6 induces thermal hyperalgesia in rats." Brain Res.692. 123-128 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Oka, T., Oka, K., Hosoi, M., Aou, S.& Hori, T.: "The opposing effects of interleukin-1beta microinjected into the preoptic hypothalamus and the ventromedial hypothalamus on nociceptive behavior in rats." Brain Res.700. 271-278 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Katafuchi, T., Hori, T., Oomura, Y.& Koizumi, K.: "Cerebellar afferents to neuroendocrine cells : implications for adaptive responses to stimulated weightlessness." Endocrine J.42. 729-737 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Ota, K., Katafuchi, T., Motomura, K., Baba, S.& Hori, T.: "Responses of the rat ventromedial hypothalamic neuron activity to tumor necrosis factor-alpha." In : Body Temperature and Metabolism (Eds.Nagasaka, T.& Milton, A.S.) IPEC,Inc., Tokyo. 34-36 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Katafuchi, T., Ota, K., Takaki, A.& Hori, T.: "Prostanoids-dependent responses of AV3V neurones to blood-borne IL-1beta : a possible implication in the blood cytokines-brain signal transduction." In : Body Temperature and Metabolism (Eds.Nagasaka, T.& Milton, A.S.) IPEC,Inc., Tokyo. 37-40 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Oka, T., Hosoi, M., Oka, K., Aou, S.& Hori, T.: "Central prostaglandin E2-induced fever and hyperalgesia are mediated by different types of EP receptors." In : Body Temperature and Metabolism (Eds.Nagasaka, T.& Milton, A.S.) IPEC,Inc., Tokyo. 37-40 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hori, T., Katafuchi, T., Take, S., Shimizu, N.& Niijima, A.: "The autonomic nervous system as a communication channel between the brain and the immune system." Neuroimmunomodulation. 2. 203-215 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hori, T., Katafuchi, T., Take, S., Kaizuka, Y., Ichijyo, T.& Shimizu, N.: "The hypothalamo-sympathetic nervous system modulates peripheral cellular immunity." Neurobiology. 3. 309-318 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Aou, S., Shiramine, K., Ma, J., Matsui, H.& Hori, T.: "Hypothalamus regulates calcium metabolism in rats." Neurobiology. 3. 339-350 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Katafuchi, T., Take, S.& Hori, T.: "Roles of cytokines in the neural-immune interactions : modulation of NMDA responses by IFNalpha." Neurobiology. 3. 319-328 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Sasaki, K., Oomura, Y., Li, A.J., Hanai, K., Tooyama, I., Kimura, H., Yanaihara, N.& Hori, T.: "Actions of acidic fibroblast growth factor fragments on food intake in rats." Obesity Research. 3 (Suppl 5). 697S-706S (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Uchimura, D., Katafuchi, T., Hori, T.& Yanaihara, N.: "Facilitatory effects of pituitary adenylate cyclase activating polypeptide (PACAP) on neurons in the magnocellular portion of the rat hypothalamic paraventricular nucleus (PVN) in vitro." J.Neuroendocrinol. 8. 137-143 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Li, A-J., Oomura, Y., Hori, T., Aou, S., Sasaki, K., Kimura, H.& Tooyama, I.: "Fibroblast growth factor receptor-1 in the lateral hypothalamic area regulates food intake." Exptl.Neurol.137. 318-323 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Shimizu, N., Kaizuka, Y., Hori, T.& Nakane, H.: "Immobilization increases noradrenaline release and reduces NK cytotoxicity in spleen of conscious rat." Am.J.Physiol.271. R537-R544 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Mo, Z.L., Katafuchi, T.& Hori, T.: "The effects of IL-1beta on neuronal activities in the dorsal motor nucleus of the vagus in rat brain slices." Brain Res.Bull.41. 249-255 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Oka, T., Wakugawa, Y., Hosoi, M., Oka, K.& Hori, T.: "Intracerebroventricular injection of tumor necrosis factorEphi induces thermal hyperalgesia in rats." Neuroimmunomodulation. 3. 135-140 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hori, T., Kaizuka, Y.& Katafuchi, T.: "Thermoregulation and immunity : the brain-immune interaction mechanisms." In : Physiological Basis of Occupational Health : Stressful Environments. (ed.Shiraki, K., Sagawa, S.& Yousef, M.K.) SPB Academic Publishing bv, Amsterdam. 31-40 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Oka, T., Oka, K., Hosoi, M.& Hori, T.: "Inhibition of peripheral interleukin-1-beta-induced hyperalgesia by the intracerebroventricular administration of diclofenac and alpha-melanocyte-stimulating hormone." Brain Res.736. 237-242 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Oka, K., Takaki, A., Katafuchi, T.& Hori, T.: "The AV3V neurons which send axons to hypothalamic nuclei respond to the systemic injection of IL-1beta." Am.J.Physiol.(in press, ). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Oka, T.Hosoi, M., Oka, K.& Hori, T.: "Biphasic alteration in the trigeminal nociceptive neuronal responses after intracerebroventricular injection of prostaglandin E2 in rats." Brain Res.(in press, ). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Li.A.J., Katafuchi, T., Oda, S., Hori, T.& Oomura, Y.: "Interleukin-6 inhibits long-term potentiation in rat hippocampal slices." Brain Res.(in press, ). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Katafuchi, T., Motomura, K., Baba, S., Ota, K.& Hori, T.: "Differential effects of tumor necrosis factor-alpha and-beta on the rat ventromedial hypothalamic neurons in vitro." Am.J.Physiol.(in press, ). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hori, T., Katafuchi, T., Take, S., Kaizuka, Y., Ichijyo, T.& Shimizu, N.: Immune cytokines modulate peripheral cellular immunity through the hypothalamo-sympathetic nervous system. In : Integrative and Cellular Aspects of Autonomic Functions : Temperature and Osmoregulation. (Eds.Pleschka, K.& Gerstberger, R.) John Libbey Eurotext, Paris, 125-129 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hori, T.& Kaizuka, Y.: Thermoregulatory responses in view of the brain-immune interactions. In : Recent Advances in Medical Balneology and Climatology. Hokkaido University Medical Library Series vol.34 (ed.by Agishi, H.& Otsuka, Y.) Hokkaido University School of Medicine, 111-118 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Hori, T., Katafuchi, T., Take, S., Kaizuka, Y.& Shimizu, N.: The brain IFNEphi suppresses NK activity via an opioid-dependent activity of hypothalamus and sympathetic activity. In : Discussion on Future Directions in Psychoneuroimmunology and Cancer.(eds.Sendo, F.& Herberman, R.B.) Nishimura Co., Ltd, Niigata and Smith-Gordon and Co., Ltd, London, 108-110 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Uchimura,D.: "Facilitatory effects of pituitary adenylate cyclase activating polypeptide(PACAP)on neurons in the magnocellular portion of the rat hypothalalmic paraventricular nucleus(PVN)in vitro." J.Neuroendocrinol.8. 137-143 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Li,A-J.: "Fibroblast growth factor receptor-1 in the lateral hypothalamic area regulates food intake." Exptl.Neurol.137. 318-323 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Shimizu,N.: "Immobilization increases noradrenaline release and reduces NK cytotoxicity in spleen of conscious rat." Am.J.Physiol.271. R537-R544 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Mo,Z.L.: "The effects of IL-1 β on neuronal activities in the dorsal motor mucleus of the vagus in rat brain slices." Brain Res.Bull.41. 249-255 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Oka,T.: "Intracerebroventricular injection of tumor necrosis factor α induces thermal hyperalgesia in rats." Neuroimmunomodulation. 3. 135-140 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Oka,T.: "Inhibition of peripheral interleukin-1- β -induced hyperalgesia by the intracerebroventricular administration of diclofenac and α -melanocyte-stimulating hormone." Brain Res.736. 237-242 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Ota,K.: "The AV3V neurons which send axons to hypothalamic nuclei respond to the systemic injection of IL-1 β." Am.J.Physiol.(in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Oka,T.: "Biphasic alteration in the trigeminal nociceptive neuronal responses after intracerebroventricular injection of prostaglandin E2 in rats." Brain Res.(in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Li,A.J.: "Interleukin-6 inhibits long-term potentiation in rat hippocampal slices." Brain Res.(in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] Katafuchi,T.: "Differential effects of tumor necrosis factor- α and - β on the rat ventromedial hypothalamic neurons in vitro." Am.J.Physiol.(in press). (1997)

    • Related Report
      1996 Annual Research Report
  • [Publications] 片渕俊彦: "交感神経による脾臓ナチュラルキラー細胞活性制御の視床下部機序" 自律神経. 33. 267-272 (1996)

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      1996 Annual Research Report
  • [Publications] 岡孝和: "痛みと情動" Clinical Neuroscience. 14. 1025-1027 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 堀 哲郎: "発熱の病態生理" Today's Therapy. 20. 115-118 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hori,T.: "Discussion on Future Directions in Psychoneuroimmunology and Cancer." Nishimura Co.,Ltd.and Smith-Gordon Co.,Ltd., 166 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Hori,T.: "Physiological Basis of Occupational Health:Stressful Environments." SPB Academic Publishing bv, 278 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 堀 哲郎: "現代の神経内分泌学" メディカル・サイエンス・インターナショナル, 506 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 堀 哲郎: "最新内科学大系、PartI.内科総論部門、第2巻「科学としての内科学」" 中山書店, 372 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Matsui,H.: "The central action of parathyroid hormone on blood calcium and hypothalamic neuronal activity in the rat." Am.J.Physiol.268. R21-R27 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Nakashima,T.: "Naloxone suppresses the rising phase of fever induced by interferon α." Brain Res.Bull.37. 61-66 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Take,S.: "Interferon-α acts at the preoptic hypothalamus to reduce natural killer cytotoxicity in rats." Am.J.Physiol.268. R1406-R1410 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Niijima,A.: "The effect of interleukin-1 β on the efferent activity of the vagus nerve to the thymus." J.Autonom.Nerv.System. 54. 137-144 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ando,T.: "Intracerebroventricular injection of prostaglandin E2 increases splenic sympathetic nerve activity in rats." Am.J.Physiol.269. R662-R668 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Oka,T.: "Intracerebroventricular injection of interleukin-6 induces thermal hyperalgesia in rats." Brain Res.692. 123-128 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Oka,T.: "The opposing effects of interleukin-1 β microinjected into the preoptic hypothalamus and the ventromedial hypothalamus on nociceptive behavior in rats." Brain Res.700. 271-278 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Uchimura,D.: "Facilitatory effects of pituitary adenylate cyclase activating polypeptide (PACAP) on neurons in the magnocellular portion of the rat hypothalamic paraventricular nucleus (PVN) in vitro." J.Neuroendocrinol.8. 137-143 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Katafuchi,T.: "Cerebellar afferents to neuroendocrine cells:implications for adaptive responses to stimulated weightlessness." Endocrine J.42. 729-737 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hori,T.: "The autonomic nervous system as a communication channel between the brain and the immune system." Neuroimmunomodulation. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Hori,T.: "The hypothalamo-sympathetic nervous system modulates peripheral cellular immunity." Neurobiology. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Aou,S,: "Hypothalamus regulates calcium metabolism in rats." Neurobiology. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Katafichi,T.: "Roles of cytokines in the neural-immune interactions:modulation of NMDA responses by IFN α." Neurobiology. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Shimizu,N.: "Behavioral,neurochemical and electrophysiological studies of stress-induced anorexia in rats." Neurobiology. (in press). (1996)

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      1995 Annual Research Report
  • [Publications] 片渕俊彦: "脳-免疫系連関とサイトカイン" 別冊・医学のあゆみ、免疫疾患-state of arts. 94-97 (1995)

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      1995 Annual Research Report
  • [Publications] 堀哲郎: "脳・免疫系連関からみた発熱" 臨床と研究. 72. 2381-2386 (1995)

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      1995 Annual Research Report
  • [Publications] 粟生修司: "視床下部を中心とする性行動・情動行動制御機構:視床下部機能の新しい側面" 日本生理学雑誌. 57. 155-163 (1995)

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      1995 Annual Research Report
  • [Publications] 片渕俊彦: "交感神経系を介する免疫調節" 第24回日本医学会総会会誌. III. 79 (1995)

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  • [Publications] 堀哲郎: "免疫系連関と発熱" 第24回日本医学会総会会誌. II. 538-539 (1995)

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  • [Publications] 岡孝和: "痛みと情動" Clinical Science. (in press). (1996)

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  • [Publications] Hori,T.: "Recent Advances in Medical Balneology and Climatology,Hokkaido University Medical Library Series vol.34" Hokkaido University School of Medicine., 158 (1996)

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  • [Publications] Hori,T.: "Thermoregulation and immunity:the brain-immune interaction mechanisms.Physiological Basis of Occupational Health:Stressful Environments." SPB Academic Publishing,Amsterdam,The Netherlands(in press), (1996)

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  • [Publications] Hori,T.: "Brain Function in Hot Environment:Basic and Clinical Perspectives.Progress in Brain Research" Elsevier,Amsterdam,The Netherlands(in press), (1996)

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  • [Publications] 堀 哲郎: "脳と免疫系との相互対話 脳と免疫(大村裕、堀哲郎編)" 共立出版, 195 (1995)

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  • [Publications] 堀哲郎: "脳と免疫精神活動の流れを遡る-機能・構造・物質-" メディカル・ジャーナル社, 196 (1995)

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  • [Publications] 武 幸子: "一般免疫機能測定 自律神経機能検査(第2版)" 文光堂, 414 (1995)

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  • [Publications] 堀 哲郎: "脳・免疫系相互連関 現代病理学大系 補遺1(横山武 他編)" 中山書店, 261 (1995)

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  • [Publications] 堀 哲郎: "感染と中枢神経性急性期反応 最新内科学大系、Part I.内科総論部門、第2巻「科学としての内科学」(井村裕夫編)" 中山書店, 456 (1995)

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  • [Publications] Ma,J.,et al: "Hypothalamic stimulation induces vagally mediated hypocalcemia in the rat." Brain Research Bulletin. 33. 65-69 (1994)

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  • [Publications] Shimizu,N.,et al.: "An IL-1β-induced noradrenaline release in the spleen is mediated by brain corticotropoin-releasing factor:an in vivo microdialysis study with conscious rats." Brain,Behavior & Immunity. 7. 14-23 (1994)

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  • [Publications] Szreder,Z.,et al.: "Thermoregulatory effect of intracerebral injections of neuropeptide Y in rats at different environmental temperatures." General Pharmacology. 25. 85-91 (1994)

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  • [Publications] Ma.J.,et al.: "Linkage of stress-induced hypocalcemia, gastric lesions and emotional behavior in Wistar Kyoto rats." American Journal of Physiology. 266. R960-R965 (1994)

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  • [Publications] Kuroda,Y., et al.: "Restraint stress suppresses experimental allergic encephalomyelitis in Lewis rats" Brain Research Bulletin. 34. 15-17 (1994)

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  • [Publications] Ma,J.,et al.: "Ventromedial hypothalamus mediates stress-induced hypocalcemia via the gastric vagus in rats." Brain Research Bulletin. 34. 41-45 (1994)

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  • [Publications] Aou,S.,et al.: "The effect of B-HT920,a dopamine D2 agonist, on bar-press feeding in the monkey." Physiology&Behavior. 55. 1125-1130 (1994)

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  • [Publications] Ichijo,T.,et al.: "Central interleukin-1β enhances splenic sympathetic nerve activity in rats." Brain Research Bulletin. 34. 547-553 (1994)

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  • [Publications] Katafuchi,T.,et al.: "The biphasic changes in splenic natural killer cell activity following ventromedial hypothalamic lesions in rats." Brain Research. 652. 164-168 (1994)

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  • [Publications] Oka, T., et al.: "EP1-receptor mediation of prostaglandin E2-induced hyperthermia in rats." American Journal of Physiology. 267. R289-R294 (1994)

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  • [Publications] Shimizu,N.,et al.: "CRF receptor antagonist attenuates stress-induced noradrenaline release in the medial prefrontal cortex of rats." Brain Research. 654. 145-148 (1994)

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  • [Publications] Oka,T., et al.: "Intracerebroventricular injection of interleukin-1β enhances nociceptive neuronal responses of the trigeminal nucleus caudalis in rats." Brain Research. 656. 236-244 (1994)

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  • [Publications] Oka,T., et al.: "Intracerebroventricular injection of prostaglandin E2 induces thermal hyperalgesia in rats:the possible involvement of EP3 receptors." Brain Research. 663. 287-292 (1994)

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  • [Publications] Aou,S,.et al.: "Hypothalamic linkage in stress-induced hypocalcemia, gastric damage, and emotional behavior in rats." American Journal of Physiology. 267. R38-R43 (1994)

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  • [Publications] Kanemitsu,Y.,et al.: "Production of antisense DNA probe by asymmetric PCR and its application to in situ hybridization." Nucleic Acids Symposium Series. 31. 57-59 (1994)

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  • [Publications] Nakane,H.,et al.: "Stress-induced noradrenaline release in the rat prefrontal cortex measured by microdialysis." American Journal of Physiology. 267. R1559-R1566 (1994)

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  • [Publications] Sasaki,K.,et al.: "Effects of fibroblast growth factors and related peptides on food intake by rats." Physiology & Behavior. 56. 211-218 (1994)

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  • [Publications] Matsui,H., et al.: "The central action of parathyroid hormone on blood calcium and hypothalamic neuronal activity in the rat." American Journal of Physiology. 268. R21-R27 (1995)

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  • [Publications] 堀 哲郎: "神経系と免疫系の対話" 日本臨床. 52. 55-61 (1994)

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  • [Publications] 片渕俊彦,堀 哲郎: "生理活性物質の生理学" 臨床検査. 38. 20-24 (1994)

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  • [Publications] 堀 哲郎,武 幸子: "脳と免疫系" 日本サイコオンコロジー学会誌. 7. 35-37 (1994)

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  • [Publications] Hori, T, et al.: "Immune cytokines modulate peripheral cellular immunity through the hypothalamo-sympathetic nervous system.,Integrative and Cellular Aspects of Autonomic Functions." John Libbey Eurotext(Eds Pleschka,K.& Gerstberger,R.), 554 (1994)

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  • [Publications] 堀 哲郎: "代謝と体温.現代の生理学" 金原出版(古河太郎,本田良行編), 920 (1994)

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  • [Publications] 堀 哲郎: "温・冷覚の生理学;新編感覚・知覚心理学ハンドブック" 誠信書房(大山正,今井正吾,和気典二編), 1741 (1994)

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  • [Publications] 堀 哲郎: "脳と免疫,精神活動の流れを遡る 機能・構造・物質" メディカル・ジャーナル社(早石修,伊藤正男編), 156 (1994)

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  • [Publications] 堀 哲郎,武 幸子: "脳・免疫系連関の諸問題,感染症と生体防御の基本原理-統合的視点を中心として" 第67回日本細菌学会総会事務極編, 135 (1994)

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  • [Publications] 片渕俊彦,堀 哲郎: "脳・免疫系連関における細菌の進歩,第11回「ニューロトランスミッターと疾患研究会」ワークショッププロシ-ディングス" エクセプタ・メディカ社(佐藤公道編), 89 (1994)

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  • [Publications] 片渕俊彦,堀 哲郎: "脳-免疫系連関,脳機能の解明-分子から病態まで-" 創風社(赤池紀扶,小暮久也編), 286 (1994)

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Published: 1994-04-01   Modified: 2016-04-21  

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