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Basic research on development of experimental animal model for weak heat tolerance and bbehavioral thermoregulation

Research Project

Project/Area Number 06557007
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionNagasaki University

Principal Investigator

KOSAKA Mitsuo  Institute of Tropical Medicine, Nagasaki University, Professor, 熱帯医学研究所, 教授 (30079983)

Co-Investigator(Kenkyū-buntansha) SAITO Muneo  Central Institute for Experimental Animals, Chief Research associate, 飼育技術研究室々長 (50167417)
SAKAI Akio  Shinshu University, School of Medicine, Associate Professor, 医学部, 助教授 (70020758)
YAMASHITA Shunichi  Nagasaki University, School of Medicine, Professor, 医学部, 教授 (30200679)
MATSUMOTO Takaaki  Institute of Tropical Medicine, Nagasaki University, Research associate, 熱帯医学研究所, 助手 (60199875)
OHWATARI Nobu  Institute of Tropical Medicine, Nagasaki University, Research associate, 熱帯医学研究所, 助手 (80128165)
土屋 勝彦  長崎大学, 熱帯医学研究所, 助教授 (90073006)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥18,500,000 (Direct Cost: ¥18,500,000)
Fiscal Year 1995: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 1994: ¥14,000,000 (Direct Cost: ¥14,000,000)
KeywordsPika / Ochotna / Thermal insulation / Thermal tolerance / hibernator / Telemetry / Body temperature / Skin hair / アフガン・ナキウサギ / クチグロ・ナキウサギ / テレメトリー / 乳酸値 / 高体温 / 血糖値 / 日内リズム / 弱熱耐性 / 行動性体温調節 / 実験動物モデル / 寒冷ショック蛋白(CSP) / 熱ショック蛋白(HSP) / SDS-PAGE / Western Blotting
Research Abstract

(1) A Field Study of Telemetry-Recording of the Body Temperature in Wild Mongolian Pika
The pika inhabiting in cold zone or in high mountains is thought to be adapted to cold as well as high-altitude environment. We have reported pika's high body temperature (39.6゚C), high metabolism and poor heat loss ability such as poor lack of thermal salivation. In this study, we measured the body temperature of wild pikas (Ochotona daurica) with a telemetry device in their natural borrows in Mongolia. Two pikas captured at Under Dov were implanted with transmitters in the abdominal cavity under anesthesia, and were returned to the own habitat. The mean body temperatures of the pakas were 39.65゚C and and 39.96゚C,though the data were limited to a short period of less than one day. The present results in wild pikas support pika's high body temperature in our previous studies.
(2) Anatomical observations and thermal tolerance in pika (Ochotona curzoniae)
The heat insulations of chest and abdomen skin were inferior to back and waist. For pikas lying on their belly is a behavioral heat loss response. The high altitude adaptation of Pika in cold environment is due to heat conservation and heat production to be different from cold tolerance in hypothermia like as hibernator.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (32 results)

All Other

All Publications (32 results)

  • [Publications] 小坂光男: "ナキウサギ(pika)の弱熱耐性" 学術月報. 47(4). 89- (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Sakai,A.: "Physiological characteristics of Pika Ochotona for adaptation to high-altitude" Jounal of Growth. 33. 103-106 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 小坂光男: "発汗-発汗の中枢機序と汗腺の神経支配-新しい観点からみた器官" 生体の科学. 45(4). 371-380 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tsuchiya,K.: "Vasoconstriction induced by β-adrenerigic antagonist in the tail of chronic spinal rats" Tropical Medicine. 37(4). 175-183 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Matsumoto,T.: "A field study of telemetry-recording of the body temperature in wild Mongolian Pikas" Tropical Medicine. 37(3). 93-98 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kosaka,M.: "A new approach to analysis of human sweating" Experientia. 52(2). 131-135 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kosaka,M.: "In Integrative and cellula spects of autonomic function: Temperature and osmoregulation" Ed. by Pleschka, R.Gersberger John Libbey Eurotext Paris, 554 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kosaka,M.: "Body Temperature and Metabolism" Ed. by T.Nagasaka and A.S.Milton IPEC(International Press Editing Centre Incorporation)Tokyo, 234 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kosaka, M.: "Weak heat tolerance of Pika (Ochotona)." Gakujutsu Peppo. 47(4). 89 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Sakai, A: "Physiological characteristics of Pika Ochotona for adaptation to high-altitude" Jounal of Growth. 33. 103-106 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kosaka, M.: "Sweat gland-Central and pheripheral mechanism of thermal sweating-" Seitai no Kagaku. 45(4). 371-380 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tsuchiya, K.: "Vasoconstriction induced by beta-adrenergic antagonist in the tail of chronic spinal rats." Tropical Medicine. 37(4). 175-183 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Matsumoto, T.: "A field study of telemetry-recording of the body temperature in wild Mongolian Pikas." Tropical Medicine. 37(3). 93-98 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kosaka, M.: "A new approach to analysis of human sweating." Exoerientia. 52(2). 131-135 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kosaka, M.: In Integrative and cellula spects of autonomic function : Temperture and osmoregulation. Ed.by K.Pleschka, R.Gersberger John Libbey Eurotext Paris, 554 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kosaka, M.: Body Temperature and Metabolism. Ed.by T.Nagasaka and A.S.Milton IPEC (International Press Editing Center Incorporation) Tokyo, 234 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Mitsuo Kosaka: "A Field Study of Telemetry-Recording of The Body Temperature in Wild Mongolian Pikas" Trop.Med.37(3). 93-98 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Shunichi Yamashita: "Expression of Parathyroid Hormone-Related Proteins in Rat Articular Cartilage" Calcif Tissue Int. 57. 196-200 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Shunichi Yamashita: "Effect of Transforming Growth Factor-β on the Insulin-like Growth Factor-1 Autocrine/Paracrine Axis in Cultured Rat Articular Chondrocytes" Experimental Cell Research. 215. 9-16 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Akio Sakai: "Lung Cyclic Nucleotides in Exercis-Trained Rrained Rats Attenuate Hypoxic Pulmonary Vasoconstriction" Lung. 173. 363-372 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Akio Sakai: "Effects of exercise-training on hypoxia and angiotensin II-induced pulmonary vasoconstrictions" Acta Physiol.Scand. 155. 291-295 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Mituo Kosaka: "Physiological characteristics of Pika Ochotona for adaptation to high-altitude" J.of Growth. 33(2). 103-106 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Mituso Kosaka: "Body Temperature and Metabolism" Ed.by Nagasaka and A.S.Milton International Press Editing Centre Incorporation,Tokyo, 232 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Munenori Shimazu: "Body Temperature and Metabolism" Ed.by Nagasaka and A.S.Milton International Press Editing Centre Incorporation,Tokyo, 232 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ohwatari N.: "Circadian and seasonal changes in metabolism,core temperature and circulation in the European hamuster." European Journal of Physiology. 426(6)Suppl.R121 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 小坂光男: "ナキウサギ(Pika)の弱熱耐性" 学術月報. 47(4). 89 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 小坂光男: "温度感受性変異株tsFT101細胞の熱ショック蛋白質誘導の解析" 日本ハイパサーミア誌. 10(3). 294 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Kosaka M.: "Heat shock proteins(HSPs) and the role of biological functions." 日本内分泌学会雑誌. 70(3). S10 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 小坂光男: "ナキウサギ(Pika)の弱熱耐性" 日本内分泌学会雑誌. 70(3). 89 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ohwatari N.: "Cold tolerance of the hibernator,Syrian hamster,during induced-hypothermia by acute cold exposure." 臨床体温. 14(1). 126-129 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ohwatari N.: "Ed by Takashi Shimoyama,Hyogo College" Hyperthermic oncology in Japan '93, 300 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 野村達次: "平成4〜5年度科学研究費補助金国際学術研究学術調査研究成果報告書" 財団法人実験動物中央研究所, 100 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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