| Project/Area Number |
06557041
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 試験 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
KITABATAKE Akira Hokkaido University School of Medicine, Professor, 医学部, 教授 (00124769)
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| Co-Investigator(Kenkyū-buntansha) |
CHIHARA Kunihiro Nara Institute of Science and Technology, Professor, 情報科学研究科, 教授 (80029561)
YAMAMOTO Katsuyuki Hokkaido University System and Information Engineerting, Professor, 工学部, 教授 (10088867)
MIKAMI Taisei Hokkaido University Hospital, Assistant Professor, 医学部・附属病院, 講師 (90250456)
KAWAGUCHI Hideaki Hokkaido University School of Medicine, Professor, 医学部, 教授 (70161297)
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| Project Period (FY) |
1994 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥18,200,000)
Fiscal Year 1996: ¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 1995: ¥5,800,000 (Direct Cost: ¥5,800,000)
Fiscal Year 1994: ¥8,000,000 (Direct Cost: ¥8,000,000)
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| Keywords | multiple resonance ultrasonic transducer / attenuation coefficient / myocardial tissue characterization / pathological myocardium / cardiac failure / cardiac function / cardiomyopathic hamster / 心筋症 |
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| Research Abstract |
Although myocardial biopsy is one the most invasive techniques among those employed for the diagnosis of cardiac disease, it has been used as an indispensable method to assess the degree of myocardial cellular damage which is a very important determinant of the patients' prognosis. The purpose of this study is to develop a new method for myocardial tissue characterization, using multiple resonance technique of ultrasound. In this study, we succeeded to develop a multiple resonance ultrasonic transducer which is able to transmit ultrasound pulses of multiple frequencies from a few MHz up to 100 MHz or more. We also developed a dedicated software to analyze the multiple resonance radiofrequency signals. Using this system, we studied ultrasonic attenuation properites of pathlogical myocardial specimens from patients with myocardial infarction and dilated cardiomyopathy. As an index for tissue characterization, we employed the value of b in the equation alpha=f^b, where alpha indicates attenuation coefficient and f indicates frequency. The b value of the pathological myocardium was smaller than that of normal myocardium and this result suggests that the b value could be used as a new index for myocardial tissue damage. Further application of the multiple resonance technique may provide some other useful information, such as regional myocardial wall dynamics and Doppler flow velocity, simultaneously with tissue characterization. Although there remain several obstacles to be overcome before clinical use of this method, this developmental study provides a new research field which will contribute to myocardial tissue characterization.
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