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Development of RF interstitial capacitive hyperthermic system for malignant brain tumor.

Research Project

Project/Area Number 06557077
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionNiigata University

Principal Investigator

TANAKA Ryuichi  Niigata University, Brain research Institute, Professor, 脳研究所, 教授 (30018816)

Co-Investigator(Kenkyū-buntansha) KIRYU Toru  Niigata University, Scool of Faculty, professor, 工学部, 教授 (80115021)
WATANABE Masato  Niigata University, Brain Research Institute, Assistant, 脳研究所, 助手 (30221691)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥6,600,000 (Direct Cost: ¥6,600,000)
Fiscal Year 1995: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1994: ¥5,600,000 (Direct Cost: ¥5,600,000)
KeywordsBrain tumor / Hyperthermia / Radiofrequency / Interstitial hyperthermia / radiofreguency
Research Abstract

In order to establish the hyperthermic system of RF interstitial capacitive heating, we studied development of RF antennas, operative technique for implant and clinical appling. A Pase I/II clinical trial has been initiated to determined the feasibility of an interstitial hyperthermia using 13.56MHz radiofrequency (RF) antennas in the treatment of malignant brain tumors. The needle type applicator (RF antennas) with diameter of 1.0mm was developed. A single or multiple (2-4) antennas were inserted into the brain tumor using a CT-guided stereotactic apparatus. The temperature of the brain and the tumor were monitored by the copper-constantan thermocouple sensors. The RF interstitial hyperthermia was performed on 30 patients with malignant brain tumors, 22 malignant gliomas (10 primary and 12 recurrent), 7 metastatic tumor and 1 malignant lymphoma. The rim of the tumors which were defined by contrast enhanced CT was heated at 43.0゚C for 60 minutes. The heating was repeated 3-9 (mean 5) times, once or twice a week, combined with conventional radiation or chemotherapy. The recurrent gliomas were treated with heat alone. The patients complained no local pain or heat sensation and well tolerated the repeated heating. No major complication occurred except liquorrhea in 2 cases, subcutaneous infection in one case, intratumoral hemorrhage in one case and trasient neurological symptoms in 2 cases. The anti-tumor effects were evaluated by CT and the treated tumors showd CR in 8, PR in 10, ST in 9 and PD in 3 cases, respectivery. In most of CR cases, the perifocal low density lesion also disappeared. These preliminary results indicated that the RF interstitial hyperthermia seemed to be effective in treatment of malignant brain tumors, this technique is less invasive and the tumors in aged or poor risk patients as well as deep-seated tumors can be good candidates for the application.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 高橋英明: "脳腫瘍の新しい治療法、温熱療法" CLINICAL NEUROSCIENCE. 12. 657-659 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 高橋英明: "悪性脳腫瘍の組織内温熱療法-RF加温による臨床成績-" 日本ハイパーサーミア学会誌. 11. 61-67 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 高橋英明: "脳腫瘍に対する温熱治療のための温度分布シミュレーション-二次元有限要素解析によるcomputer simulation-" 日本ハイパーサーミア学会誌. 11. 356-364 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takahashi H., Tanaka R., et al: "New treatment for brain tumor, hyperthermia." CLINICAL NEUROSCIENCE. 12. 657-659 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takahashi H., Tanaka R., et al: "Clinical results of RF interstitial hyperthermia for malignant brain tumors." Jpn.J.Hyperthermic Oncol.11. 61-67 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takahashi H., Tanaka R., et al: "Computer simulation of temperature distribution for brain tumor hyperthermia using the two dimmensional finite elements method." Jpn.J.Hyperthermic Oncol.11. 356-364 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 高橋英明: "悪性脳腫瘍の組織内温熱療法-RF加温による臨床成績-" 日本ハイパーサーミア学会誌. 11. 61-67 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 高橋英明: "悪性脳腫瘍の組織内温熱療法のためのコンピュータシミュレーション" 日本ハイパーサーミア学会誌. 11. (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 田中隆一: "脳腫瘍-RF外部加温とRF組織内加温-" 医学のあゆみ. 168. 24-29 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 高橋英明,田中隆一: "脳腫瘍の新しい治療法 温熱療法" CLINICAL NEUROSCIENCE. 12. 657-659 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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