| Project/Area Number |
06557092
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 試験 |
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| Research Field |
小児外科
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| Research Institution | Tohoku University |
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Principal Investigator |
CHIBA Toshio Tohoku University, Pediatric Surgery, (Lecturer), 医学部・付属病院, 講師 (20171944)
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| Co-Investigator(Kenkyū-buntansha) |
SHIRANE Reizo Tohoku University, Neurosurgery, (Lecturer), 医学部・付属病院, 講師 (30206297)
HONGO Michio Tohoku University, Comprebensive Meeicine, (Professor), 医学部・付属病院, 教授 (60133948)
HANDA Yasunobu Tohoku University, Department of Restorative Newromuzculer surgery and Rehabilit, 医学部, 教授 (00111790)
OKI Ryoji Tohoku University, Pediatric Surgery, (Professor), 医学部, 教授 (50004734)
曽 尚文 東北大学, 医学部・附属病院, 助手 (90236133)
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| Project Period (FY) |
1994 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥12,200,000 (Direct Cost: ¥12,200,000)
Fiscal Year 1996: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1995: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1994: ¥9,000,000 (Direct Cost: ¥9,000,000)
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| Keywords | Gastrocolic reflex / Strain gauge / Colonic Pacing / FES / FES / 自然排便モデル / 結腸運動誘発ペーシング / バイポーラー針電極 / 結腸運動解析 / ストレインゲージ法 / リング状センサー開発 / 結腸強収縮活動 / FESシステム / 結腸運動解析法 / リング状センサー / 骨髄座筋群 / 体内埋込み型情報リレー装置 |
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| Research Abstract |
ABSTRACT
Using dogs, we first investigated colonic mechanical behavior specifically preceding physiological defection. To fulfilll this aim, four strain gaugages were fixed by suturing onto the colonic wall, and we recorded and evaluated colonic mechanical activities caused by tube feedings in awake and nonrestricted animals which potetially provoke gastrocolic reflex. As a consequence, mechanical contractions associated with ordinary defecation proved to be most prominent in the descending colon. On the other hand, another study for developing a technique of colonic electrical pacing was undertaken because current way based on tube feeding did not always led to subsequent defecation in our experiment. In this test, we concluded that electrical stimulation of the colon worked better when applied from inside, and the best pacing condition was specified as a combination of10 volts in voltage, 20 msec in duration, and 30 beats per minute in frequency. Our outcome is sure to support our goal of controlling fecal incontinence by a new self-limited circuit system consisting of an early perception of colonic behavior preceding bowel movements, and electrically-linked FES (so called functional electrical stimulation) of anal sphincter muscle which is insufficient for holding messy fecal soiling.
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