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Development of Surface Nanostructure Control Method of Biomaterials by Utilizing Organosilane Monolayrs

Research Project

Project/Area Number 06558126
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

TAKAHARA Atsushi  Kyushu University, Dept.Chem.Sci.Tech., Associate Professor, 工学部, 助教授 (20163305)

Co-Investigator(Kenkyū-buntansha) GE Shouren  Kyushu University, Dept.Chem.Sci.Tech., Research Associate, 工学部, 助手 (80274504)
菊池 裕嗣  九州大学, 工学部, 助教授 (50186201)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 1995: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1994: ¥3,500,000 (Direct Cost: ¥3,500,000)
KeywordsOrganosilane / Monolayr / Phase-separation / Surface Structure Control / Atomic Force Microscopy / Protein Adsorption / Patterning / Nanostructure / 有機シラン単分子膜 / 相分離構造 / 固定化単分子膜
Research Abstract

Alkyltrichlorosilanes, [2- (perfluorooctyl) ethyl] trichlorosilane (FOETS) and their mixed monolayrs were polymerized on the water subphase and were covalently immobilized onto the silicon wafer surface. Atomic force microscopic (AFM) observation of the (n-octadecyltrichlorosilane (OTS) /FOETS) mixed monolayr revealed that the crystalline OTS formed circular domains of ca. 1-2 mum in diameter, which were surrounded by an amorphous FOETS matrix. Lateral force microscopic (LFM) and scanning viscoelastic microscopic (SVM) observations of the (OTS/FOETS) mixed monolayr could also distinguish the difference in the physical and mechanical properties between domain and matrix. The (alkylsilane/FOETS) mixed monolayrs with shorter alkyl chain such as n-dodecyltrichlorosilane (DDTS) did not show the phase-separated structure maybe due to the lack in crystallinity of DDTS component. AFM observation of the [crystalline fatty acid (non reactive) /FOETS (reactive)] mixed monolayr also revealed the phase-separated structure. The crystalline fatty acid domain in the mixed monolayr was extracted by solvent and then, the monolayr of FOETS with the holes of ca. 1-2 mum in diameter, that is, the (Si/FOETS) monolayr was finally obtained. The Si phase of (Si/FOETS) was backfilled with the another organosilane by chemisorption. Then, the [(3-mercaptopropyl) trimethoxysilane (MTS) /FOETS] mixed monolayr was newly obtained by the chemisorption of MTS.The adsorption of bovine serum albumin (BSA) onto mixed monolayrs was studied by exposure of the mixed monolayrs to a BSA solution. BSA was preferentially adsorbed onto the MTS part due to a specific reaction between disulfide bond (-S-S-) in BSA and SH groups in MTS.On the other hand, in the case of (OTS/FOETS) mixed monolayr, BSA adsorbed preferentially onto the FOETS matrix in order to minimized the interfacial free energy in the aqueous environment.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (31 results)

All Other

All Publications (31 results)

  • [Publications] S.-R.Ge,A.Takahara,T.Kajiyama: "Aggregation Structure and Surface Properties of Immobilized Organosilane Monolayers Prepared by the Upward Drawing Method" J.Vac.Sci.Tech.A,. 12. 2530-2536 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] A.Takahara,K.Korehisa,S.-R.Ge,T.Kajiyama: "Effect of Surface Microphase-Separated Structure on Interaction between Biological Components and Multiphase Polymer Surface" J.Vac.Sci.Tech.A,. 12. 2956-2961 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S.-R.Ge,A.Takahara,T.Kajiyama: "Direct Observation of the Phase-separated Structure in (Polyalkylsilane/Polyfiuroalkylsilane) Mixed Monolayer Surface by Scanning Force Microscopy" Rept.Progr.Polym.Phys.,Japan. 37. 315-318 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Kajiyama,K.Tanaka,I.Ohki,S.R.Ge,J.S.Yoon,A.Takahara: "Imaging of Dynamic Viscoelastic Properties of Phase Separated Polymer Surface by Forced Oscillation Atomic Force Microscopy" Macromolecules. 27. 7932-7934 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S.R.Ge,A.Takahara,T.Kajiyama: "Phase Separated Morphology of Immobilized Organosilane Monolayer Studied by Scanning Force Microscope" Langmuir. 11. 1341-1346 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Kajiyama,I.Ohki,K.Tanaka,S.-R Ge,A.Takahara,: "Direct Observation of Surface Morphology and surface Viscolastic Properties of Polymeric Solids Based on Scanning Force Microscopy,"" Proc.Japan Academy. 71B. 75-80 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] A.Takahara,S.-R.Ge,T.Kajiyama: "Two-dimensional Surface Structure Control by Utilizing Organosilane Monolayers," Molecular Electronics and Devices. 137-147 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 高原 淳: "高分子固体の表面構造と表面分子運動特性" 高分子. 44. 576-580 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Kojio,S.-R.Ge,A.Takahara,T.Kajiyama: "Effect of Chemical Structure of Fluoroalkylsilane on Phase-separation State of (Alkylsilane/Fluoroalkylsilane) Mixed Monolayers" Rept.Progr.Polym.Phys.Japan. 38. 2879-282 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] A.Takahara,K.Kojio,S.R.Ge,T.Kajiyama: "in Advances in Biomedical Polymers in Biomedical Engineering and Drug Delively Systems" T.Okano,Y.Sakurai et al. Springer,Tokyo, 2 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S.-R.Ge, A.Takahara, T.Kajiyama: "Aggregation Structure and Surface Properties of Immobilized Organosilane Monolayrs Prepared by the Upward Drawing Method" J.Vac.Sci.Tech.A. Vol.12. 2530 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] A.Takahara, K.Korehisa, S.-R.Ge, T.Kajiyama: "Effect of Surface Microphase-Separated Structure on Interaction between Biological Components and Multiphase Polymer Surface" J.Vac.Sci.Tech.A. Vol.12. 2956 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S.-R.Ge, A.Takahara, T.Kajiyama: "Direct Observation of the Phase-separated Structure in (Polyalkylsilane/Polyfiuoroalkylsilane) Mixed Monolayr Surface by Scanning Force microscopy" Rept.Progr.Polym.Phys., Japan. Vol.37. 315 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Kajiyama, K.Tanaka, I.Ohki, S.R.Ge, J.S.Yoon, A.Takahara: "Imaging of Dynamic Viscoelastic Properties of Phase Separated Polymer Surface by Forced Oscillation Atomic Force Microscopy" Macromolecules. Vol.27. 7931 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S.R.Ge, A.Takahara, T.Kajiyama: "Phase Separated Morphology of Immobilized Organosilane Monolayr Studied by Scanning Force Microscope" Langmuir. Vol.11. 1341 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] A.Takahara: "Surface structure and Surface Molecular Motion of Polymeric Solids" Kobunshi. Vol.44. 576 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Kajiyama, I.Ohki, K.Tanaka, S.-.R Ge A.Takahara: "Direct Observation of Surface Morphology and Surface Viscoelastic Properties of Polymeric Solids Based on Scanning Force Microscopy" Proc.Japan Academy. Vol.71B. 75 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] A.Takahara, S-R.Ge, T.Kajiyama: "Two-dimensional Surface Structure Control by Utilizing Organosilane Monolayrs" Molecular Electronics and Devices. 137 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Kojio, S.-R.Ge, A.Takahara, T.Kajiyama: "Effect of Chemical Structure of Fluoroalkylsilane on Phase-separation State of (Alkylsilane/Fluoroalkylsilane) Mixed Monolayrs" Rept.Progr.Polym.Phys.Japan. Vol.38. 279 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] A.Takahara, K.Kojio, S.R.Ge, T.Kajiyama: "Selective Adsorption of Plasma Protein onto Phase-separated Domain of Immobilized Organosilane Monolayrs" in Advances in Biomedical Polymers in Biomedical Engineering and Drug Delivery Systems. 243 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] S.R.Ge,A.Takahara,T.Kajiyama: "Phase Separated Morphology of Immobilized Organosilane Monolayer Studied by Scanning Force Microscope" Langmuir. 11. 1341-1346 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T.Kajiyama,I.Ohki,K.Tanaka S.-.R Ge A.Takahara,: "Direct Observation of Surface Morphology and Surface Viscolastic Properties of Polymeric Solids Based on Scanning Force Microscopy,"" Proc.Japan Academy. 71. 75-80 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] A.Takahara,S-R.Ge,T.Kajiyama: "Two-dimensional Surface Structure Control by Utilizing Organosilane Monolayers," Molecular Electronics and Devices. 137-147 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] K.Kojio,S.-R.Ge,A.Takahara,T.Kajiyama: "Effect of Chemical Structure of Fluoroalkylsilane on Phase-separation State of(Alkylsilane/Fluoroalkylsilane) Mixed Monolayers" Rept.Progr.Polym.Phys.Japan. 38. 279-282 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] A.Takahara,K.Kojio,S.R.Ge,T.Kajiyama: "Selective Adsorption of Plasma Protein onto Phase-separated Domain of Immobilized Organosilane Monolayers" in Advances in Biomedical Polymers in Biomedical Engineering and Drug Delively Systems. 243-244 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 高原 淳: "高分子固体の表面構造と表面分子運動特性" 高分子.

    • Related Report
      1995 Annual Research Report
  • [Publications] S.R.Ge: "Aggregation Structure and Surface Properties of Immobilized organozilcne Monolayers Prepared by the Upward Drawing Method" Journal of Vacuum Science & Technology. A12. 2530-2536 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] S.R.Ge: "Direct Observation of the Phase-Separated Structure in (Polyalkylsilane/Polyfluoroalkylsilane)Mixed Monolayer Surface by Scanning Force Micrsocopy" Rept.Progr.Polym Phys.Japan. 37. 315-318 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Kajiyama: "Imaging of Dynamic Viscoelastic Properties of a Phase-Separated Polymer Surface by Forced Oscillation Atomic Force Microscopy" Macro molecules. 27. 7932-7934 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Kajiyama: "Direct Observation of Surface Viscoelastic Properties of Polymeric Solids Based on Scanning Force Microscope" Proc.Japan Academy Ser.B. 71. (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 梶山千里: "新高分子実験学10巻第3章" 共立出版, 29 (1955)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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