| Project/Area Number |
06610089
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
実験系心理学
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| Research Institution | Tokyo Metropolitan Institute for Neuroscience |
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Principal Investigator |
WATANABE Masataka Tokyo Metro.Inst.Neurosci.Psychology, Staff Scientist, 心理学研究部門, 副参事研究員 (50092383)
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| Co-Investigator(Kenkyū-buntansha) |
SHIRAKAWA Shuichiro National Inst.Mental Health Psychogeriatrics, Division Chief., 精神保健研究所, 精神保健研究室長 (20100141)
ODAGIRI Megumi Tokyo Metro.Inst.Neurosci.Psychology, Staff Scientist, 心理学研究部門, 主事研究員 (10260308)
HIKOSAKA Kazuo Tokyo Metro.Inst.Neurosci.Psychology, Staff Scientist, 心理学研究部門, 主事研究員 (60129004)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1995: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1994: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | Prefrontal cortex / Working memory / Delayd response / Parallel processing / Neuronal activity / Reward / 遅延反応課題 |
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| Research Abstract |
The prefrontal cortex has important functions in organizig goal-directed, purposive hehavior.Working memory is the memory process of retaining the information "on-line" while that information is necessary for the correct performance.During the delayd response task, prefrontal neurons show activity changes during the delay period ("delay neurons") , some of them showing spatial specificity depending on the cue position.This study was conducted whether prefrontal neurons are involved in retaining more than two different kinds of information in parallel.
Three monkeys were trained on three different typse of delayd response tasks with several kinds of food and liquid reward ; (1) Direct method food reward, (2) Indirect method food reward, and (3) Indirect method liquid reward.Type of task and kind of reward were changed usually in a block of 50 trials.The results of the experiment are summarized as follows.
(1) About 2/3 of delay neurons examined showed differential activity depending on whether it was a right or left trial, and thus had spatial specificity.
(2) About half of delay neurons showed differential activity depending on the difference of the reward, and thus had reward dependency.
(3) About 80% of delay neurons showed differential activity depending on the difference of the type of the task, and thus had task dependency.
(4) Substantial proportion of delay neurons with spatial specificity had reward dependency and/or task dependency as well, participating two or three different kinds of working memory.
(5)These prefrontal neurons which are involved in retaining several kinds of information in parallel, are considered to be the basis of the goal-directed behavior where parallel processing is required.
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