| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1994: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Research Abstract |
Radical reactions are one of the most useful methods for organic synthesis. Therefore, the study on the novel radical reactions with trivalent iodine compounds has been carried out. As a result, it was found that (diacyloxyiodo) arenes which has electron-donating group on a aromatic ring accelerated the radical reactivities under the irradiation with tungsten lamp as shown below,
1) conversion of carboxylic acids to the corresponding sulfides in the presence of disulfides,
2) conversion of aromatic carboxylic acids to the corresponding gamma-or delta-lactones,
3) conversion of alcohols bearing a aromatic ring to the corresponding cyclic ethers,
4) conversion of amines bearing a aromatic ring to the corresponding cyclic amines,
These reactions proceed via the formation of carbon-, oxygen-, and nitrogen-centered radicals to give the products with a simple operation in good yields. In nature, there are many kinds of important cyclic compounds containing oxygen and nitrogen atoms. Therefore, the present method is very useful for the preparation of these natural products. These results were published in three international Journals in 1995, and the other papers are in preparation for the contribution to the Journals.
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