| Project/Area Number |
06640771
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
分離・精製・検出法
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
JIN Takashi Hokkaido Univ., Res.Ins.for Elec.Sci., Instructor, 電子化学研究所, 助手 (80206367)
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| Co-Investigator(Kenkyū-buntansha) |
KINJO Masataka Hokkaido Univ., Res.Ins.for Elec.Sci., Instructor, 電子化学研究所, 助手 (70177971)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1995: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1994: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | Optical actibity / Fuorescence / Host molecule / Aminoacid / Optical purity / キラル / カリックスアレン / 光学分割 / 分子認識 / ピレン / センサー |
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| Research Abstract |
In order to develop a new fluorescence technique for the determenation of optical purity of chiral compounds, chiral calix [4] arenes labeled fluorescent moieties (pyrene) were synthesized as fluorescent indicators which interact with aminoacid ether derivatives. Optical resolution of the fluorescent chiral calix [4] arenes were carriedout by using HPLC with the aid of a chiral column. Optical activity of thesynthesized calixarenes were confirmedby the measurement of circular dechrorism of the compounds. Although the fluorescent chiral calix [4] arenes does not exhibit high sensitivities in the complexation with aminoacid ether derivatives, this research provides a basicidea for the determination of optical purity of chiral compounds using fluorescent host molecules as chiral indicators.
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