| Project/Area Number |
06640890
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
動物生理・代謝
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| Research Institution | Okazaki National Research Institutes |
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Principal Investigator |
MARUYAMA Kei Okazaki National Research Institutes National Institute for Physiological Sciences Associate Professor, 生理学研究所, 教授 (30211577)
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| Project Period (FY) |
1994 – 1996
|
| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1996: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1995: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1994: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | helix-loop-helix / NeuroD / hippocampus / neuron / subtraction / 海馬 / 神経特異的遺伝子 / 分化 / サブトラクション / クローニング / インサイチューハイブリダイゼーション / 分子生物学 / テトラエチル アンモニウム |
|---|
| Research Abstract |
In the mammalian nervous system, several basic helix-loop-helix (bHLH) proteins have been identified that may play essential roles in neurogenesis or neural development. This paper describes a novel bHLH protein in rat brain, which has a bHLH domain highly homologous with that of MATH-2and NeuroD.On the other hand, the amino-acid sequence of the other regions had little homology with those of the known proteins. This protein consists of 381 amino acids and was detected only in neural tissue, indicating that it has an important role specific to neuronal activities.
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