| Project/Area Number |
06650226
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Fluid engineering
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| Research Institution | Kansai University (1995)
National Cardiovascular Center Research Institute (1994) |
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Principal Investigator |
SUGIHARA Masako Kansai University, Faculty of Enginnering, Associate Professor, 工学部, 助教授 (80150225)
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| Co-Investigator(Kenkyū-buntansha) |
HANAI Sotaro Natl Cardiovasc Ctr Res Inst, Dept Vasc Physiol, Head, 脈管生理部, 室長(H6のみ) (20142185)
MINAMIYAMA Motomu Natl Cardiovasc Ctr Res Inst, Dept Vasc Physiol, Head, 脈管生理部, 室長(H6のみ) (00142191)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1994: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Microvessels / Vascular resistance / Stokes Flow / Numerical simulation |
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| Research Abstract |
In order to evaluate vascular resistance to flow in microvessels, we conducted in vivo measurements of luminal geometry of microvessels, and numerical simulation of flow through vessels with various geometry.
1. In vivo measurements : 1) Measurements of diameter of microvessels in rabbit mesentery by a video-photometric technique, 2) fluorescence-microscopy imaging to observe nuclei of smooth muscle cells and endothelial cells of microvessels, and 3) 3-D reconstruction of luminal geometry of microvessels in mouse skin using a confocal Laser scanning microscope, revealed that the cross-sectional shapes of microvessels are not circular, as assumed conventionally in the evaluation of vascular resistance, and that the shape is not uniform along the vessel axis.
2. Numerical simulation : A finite element method was used to analyze the flow through vessels with variable cross-sections or vessels with protrusion of endothelial nuclei into the vessel lumen, and the vascular resistance to flow was evaluated. It was found that the vascular resistance of vessels with non-uniform cross-sections is constantly higher than that of vessels with a uniform, circular cross-section. A further analysis of particle motion in flow suggested that the presence of blood cells enhances the vascular resistance of microvessels, due to fluid dynamical interaction between the nonuniform geometry of vessels and blood cells.
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