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Highly-sensitive detection of medical chemical substances using taste sensor and automatized production of chemicals with desired taste

Research Project

Project/Area Number 06650366
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Electronic materials/Electric materials
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

TOKO Kiyoshi  KYUSHU UNIV., FAC.ENG., ASSOCIATE PROF., 工学部, 助教授 (50136529)

Co-Investigator(Kenkyū-buntansha) MATSUNO Tetsuya  KYUSHU UNIV., FAC.ENG., ASSISTANT PROF., 工学部, 助手 (80243921)
MIYAJIMA Toru  KYUSHU UNIV., FAC.SCI., ASSOCIATE PROF., 理学部, 助教授 (40128103)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1994: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsLB MEMBRANE / LIPID MEMBRANE / MEMBRANE POTENTIAL / MEMBRANE IMPEDANCE / COUPLED-OSCILLATOR SYSTEM / 脂肪膜
Research Abstract

Thin lipid membranes were obtained using a Langmuir-Blodgett (LB) method. Electrochemical characteristics of the LB membranes such as the membrane resistance and capacitance were studied. This membrane-impedance measurement clarified that the electric resistance of LB membrane increased with addition of chemical substances producing bitterness, whereas it changed a little by other substances showing sourness, sweetness, saltiness and umami taste. This fact implies that bitter substances are strongly bound to the LB membrane and also suggests the mechanism of bitterness produced by many kinds of medical chemical substances.
Furthermore, taste-recognition system was developed using a kind of neural-network model to transform electric potential patterns from the taste sensor to taste qualities. It was also shown that chaos plays an important role in recognition process in a coupled-oscillator nonlinear system which mimics the a group of neurons in brain. When information that is much dofferent from already-known information was input to the system, chaotic oscillations appeared, as observed in real biological systems.
As a result, we have obtained a possibility of taste-recognition system constructed from LB membranes as a receptor part and coupled-oscillator nonlinear system as a recognition part.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] 都甲 潔: "味覚センサー" 日本化学学会誌. 1995. 334-342

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 都甲 潔: "味覚センサー" 蛋白質核酸酵素. 40. 1859-1865 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 都甲 潔: "バイオセンサのインテリジェント化" 計測と制御. 34. 42-48 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K. Toko: "Self-Organization of Electric Currents in Artificial Lipid Membranes" Physics of the Living State. 1994. 57-73

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] H. Shigematsu: "Early Grari-Electrical Responses in Bean Epicotyls" Plant Physiol.105. 875-880 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T. Miyajima: "On the Protonatio Equilibria of Cyclo-μ-Imido-Polyphosphate Anions(II)" Phosphorous Res. Bull.5. 155-160 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Tsukagoshi: "Surface imprinting.Characterization of a Latex Resin and the Origin of the Imprinting Effect" BULL. Chem. Soc. Jpn.68巻. 3095-3103 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Matsuno: "Effect of Natural Ferequency Distribution on Retrieal States in Coupled Oscillators" J. Phy. Soc. Jpn.63巻. 4335-4337 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T. Matsuno: "Pattern Recognition in Coupled Oscillators with the Ptase Coherency Output" J.Phys. Sco. Jpn.64巻. 1837-1850 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T. Matsuno: "Neural Network Model with Mean Field Output and Its Application to Reconstruction of Taste Map" Sensors and Materials. 7巻. 281-288 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Toko: "The Taste Sensor" Chem.Soc.Jpn., (in Japanese). 334-342 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Toko: "The Taste Sensor" Protein, Nucleic Acid and Enzyme, (in Japanese). 40. 1859-1865 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Toko: "Intelligent Biosensors" J.SICE,(in Japanese). 34. 42-48 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Toko: "Self-Organization of Electric Currents in Artificial Lipid Membranes" Physics of the Living State, Ohmsha. 57-73 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] H.Shigematsu: "Early Gravi-Electrical Responses in Bean Epicotyls" Plant Physiol.105. 875-880 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Miyajima: "On the Protonation Equilibria of Cyclo-mu-Imido-Polyphosphate Anions (II)" Phosphorous Res. Bull.5. 155-160 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Tsukagoshi: "Surface Imprinting. Characterization of a Latex Resin and the Origin of the Imprinting Effect" Bull.Chem Soc.Jpn.68. 3095-3103 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Matsuno: "Effect of Natural Frequency Distribution on Retrieval States in Coupled Oscillators" J.Phys.Soc.Jpn.63. 4335-4337 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Matsuno: "Pattern Recognition in Coupled Oscillators with the Phase Coherency Output" J.Phys.Soc.Jpn.64. 1837-1850 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Matsuno: "Neural Network Model with Mean Field Output and Its Application to Reconstruction of Taste Map" Sens.Materials. 7. 281-288 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 都甲 潔: "バイオセンサのインテリジェント化" 計測と制御. 34. 42-48 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 都甲 潔: "味覚センサー" 蛋白質 核酸 酵素. 40. 1859-1865 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 都甲 潔: "味覚センサー" 日本化学会誌. 334-342 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T.Matsuno: "Neural Network Model with Mean Field Output and Its Application to Reconstuction of Taste Map" Sensors and Materials. 40. 281-288 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] T.Matsuno: "Pattern Recognition in Coupled Oscillators with the Phase Coherency Output" Journal of the Physical Society of Japan. 64. 1837-1850 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] K.ToKo: "Self-Organization of Electric Currents in Artificial Lipid Membranes" Physics of the Living State. 57-73 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] H.Shigematsu: "Early Gravi-Electrical Responses in Bean Epicotyls" Plant Physiology. 105. 875-880 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Matsuno: "Effect of Natural Freguency Distribution on Retneval States in Coupled Oscillators" Journal of the Physical Society of Japan. 63. 4335-4337 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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