| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1994: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Research Abstract |
Unsaturated amines, carboxylic acids, and amino acids were dimerized by means of the flame-induced reaction in aqueous solution. Crotonic acid afforded mainly diethylsuccinic acid among three isomers expected in this reaction, indicating that the first step of the dimerization is an addition of a hydrogen atom to the C-C double bond so as to give a more stable carbon radical.
Saturated aliphatic amines and carboxylic acids were also employed as substrates and dimers were obtained in 10-20 % yields. In this case, the first step of the reaction is abstraction of a hydrogen atom from an alkyl group by a hydroxyl radical.
S-Methyl cysteine sulfoxide and methionine sulfoxide afforded 2,5-diaminoadipic acid and 2,7-diaminosuberic acid, respectively, in this reaction, thought in low yields. This reaction revealed to proceed through C-S bond cleavage by the action of a hydroxyl radical.
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