| Project/Area Number |
06660386
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
SAWADA Tsutomu Osaka Prefecture University, College of Agriculture, Professor, 農学部, 教授 (60081600)
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| Co-Investigator(Kenkyū-buntansha) |
TAMADA Hiromichi Osaka Prefecture University, College of Agriculture, Assistant Professor, 農学部, 講師 (10155252)
MORI Junichi Kitasato University, School of Veterinary Medicine and Animal Sciences, Professo, 獣医畜産学部, 教授 (90167685)
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| Project Period (FY) |
1994 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1996: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1994: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | 20alpha-dihydroprogesterone / goat / estrous cycle / luteolysis / parturition / pregnancy / Prostaglandin F2alpha / progesterone / 20α-dihydroprogesterone / goat / lnteolysis / Prostaglandin F_2α / Progesterone / estrous cycle / progesterone / Sregesterone metabolism / prostaglandin F2α / parturition / pregnancy / feto-placental unit |
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| Research Abstract |
(1) The relationships between the secretion of progesterone and 20alpha-dihydroprogesterone and the sites of their production in pregnant goats were investigated. These results suggest that in pregnant goats the main production site is the ovary for progesterone and the ovary and feto-placental unit for 20alpha-dihydroprogesterone, and 20alpha-dihydro-progesterone may take help to regulate progesterone production with in the ovary and the feto-placental unit. (Steroids 59 : 468-471,1994)
(2) The secretion of progesterone and 20alpha-dihydroprogesterone during the estrous cycle and the effects of PGF2alpha and 20alpha-dihydroprogesterone on the secretion of these two steroids during the midluteal phase in goats were studied. These results indicate that in the goat after estrus, there is muchi 20alpha-dihydroprogesterone in the peripheral plasma. Progesterone may be catabolized to the biologically inactive steroid, 20alpha-dihydroprogesterone, during luteolysis. (Steroids 59 : 672-675,1994)
(3) The relationships between the effects of single or repeated subcutaneous injections of progesterone on luteal function during the estrous cycle in goats as well as the secretion of 20alpha-dihydroprogesterone or PGFM,the major metabolite of PGF2alpha, were investigated. These results indicate that during the estrous cycle in goats, progesterone is catabolized to the biologically inactive steroid 20alpha-dihydroprogesterone, but much of the progesterone that is given early in the luteal phase of the estrous cycle causes premature luteolysis by stimulating an increase in the release of PGF2alpha. The secretion of 20alpha-dihydroprogesterone may help to regulate progesterone production during the estrous cycle in goats. (Theriogenology : in press)
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