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Molecular pathological study on the beta-amyloidogenesis in the day cerebral blood nessels.

Research Project

Project/Area Number 06660402
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Applied veterinary science
Research InstitutionTottori University

Principal Investigator

SHIMADA Akinori  Tottori Univ.AGRICULTURE Associate professor, 農学部, 助教授 (20216055)

Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1994: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsDog / Brain / beta-amyloid (betaAP) / Amyloid precursor protein (betaAPP) / βアミロイド蛋白(βAP) / βアミロイド前駆蛋白(βAPP) / mRNA
Research Abstract

beta-amyloid precursor protein (betaAPP) and beta-amyloid protein (betaAP) immunohistochemistry, and betaAPPmRNA in situ hybridization were planned in order to elucidate the beta amyloidogenesis in the dog cerebral blood vessels. 1) betaAPP staining was demonstrated in the wall of the blood vessels and occasional neurons. 2) Six cDNA fragments from the dog betaAPP mRNA were obtained by RT-PCR method. In addition, immunoelectron microscopy demonstrated 1) occasional betaAPP and betaAP immunostaining in the cytoplasm of the smooth muscles in the wall of the blood vessels ; 2) no spatial relationship was observed between the antigens and suborganellas including lysozome.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] 島田章則: "イヌの聴覚糸における形態的加齢性変化" Neuropathology. 14 supplements. 46 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hirai, T.: "Age-related changes in the olfactory system of dogs" Neuropathology and Applied Neurobiology. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] A.Shimada, M.Ebisu, T.Awakura, T.Umemura: "Age-related morphological changes in the anditory system of dogs" Neuropathology. 14 supplements. 46 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hirai, T., Shimada, A., Umemura, T., Sakai, M., Itakura, C.: "Age-nelated changes in the olfactory system of dogs." Neuropathology and Applied Neurobiology. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary

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Published: 1994-04-01   Modified: 2016-04-21  

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