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Role of the hepatic NaCl sensitive mechanism in NaCl homeostasis

Research Project

Project/Area Number 06670055
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field General physiology
Research InstitutionKagawa Medical School

Principal Investigator

HOSOMI Hiroshi  Kagawa Medical School Department of Physiology Professor, 医学部, 教授 (70030864)

Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1995: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1994: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywordsjejuno-jejunal reflex / intraluminal pressure / jejunal absorption / jejunal denervation / kainic acid / nucleus tractus solitarius / mesenteric nerve activity
Research Abstract

To examine the role of intestine in controlling body fluid homeostasis, following two experiments were conducted.
1) The aim of the first study was to investigate the role of the estrinsic nervous system in jejunal absorption under elevated intraluminal pressure of the jejunum. Anesthetized dogs were used in this experiment. Increase in intraluminal pressure from 0 to 70-100 mmHg decreased net absorption of fluid and NaCl. To examine the role of extrinsic nervous system in the depressed net jejunal absorption, jejunal afferent and efferent nerve activities were measured in response to the increase in intraluminal pressure. Both afferent and efferent nerve activities increased in response to the increase in intraluminal pressure. In the extrinsic denervated jejunal loop, the responses of net absorption were quite different from those in innervated jejunum. That is, in the denervated jejunal loop the elevation of intraluminal pressure converted jejunal absorption to jejunal secretion. The … More se results indicate that elevation of intraluminal pressure elicits the jejuno-jejunal reflex, and this mechanism counteracts jejunal secretion.
2) Effects of bilateral chemical inactivation of the nucleus tractus solitarius (NTS) by microinjection of kainic acid on fluid and NaCl absorption across the jejunum were examined in anesthetized Sprague-Dawley rats. Net fluid and NaCl absorption was significantly increased by the chemical inactivation of the NTS.To examine the efferent mechanism of the increased net absorption, mesenteric nerve activity was measured before and after the inactivation of the NTS.Mesenteric nerve activity was significantly increased after the bilateral inactivation of the NTS.Furthermore, absorption experiments were conducted in rats with pretreatment of atropine or yohimbine. In atropine treated rats, net jejunal absorption wa significantly increased by the inactivation of the NTS.However, the increase in net absorption induced by the inactivation of the NTS was completely abolished by pretreatment with yohimbine. These results suggest that the NTS has a tonic suppression on jejunal absorption through alpha2-adrenergic mechanism. Less

Report

(2 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 細見弘: "Hepato-renal reflex" 医学のあゆみ. 169. 515-519 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tanaka,Kazutaka et al.: "Effects of microinjection of kinic acid into the nucleus tractus solitarius on fluid and NaCl absorption across the jejunum" Jrnal of Autonomic Nervous System. 48. 97-104 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Morita,Hironobu et al.: "Chemical inactivaation of the nucleus tractus solitarius abolished hepatojejunal raflex in the rat" Jrnal of Autonomic Nervous System. 48. 207-212 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Murakami,Hiroshi et al.: "The rolre of extrinsic nervous system in jejunal absorption during elevation of intraluminal pressure in anesthetized dogs" Jrnal of Autonomic Nervous System. 51. 237-244 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Morita,Hironobu et al.: "Role of hepatic receptors in controlling body fluid homeostasis" Japanese Journal of Physiology. 45. 355-368 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 細見弘: "予測制御:思想と研究法" 生体の科学. 47. 77-81 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tanaka K,Morita H,Suwaki H,Hosokawa K,Hosomi H: "Effects of microinjection of kainic acid into the nucleus tractus solitarius on fluid and NaCl absorption across the jejunum." Journal of the Autonomic Nervous System. 48. 97-104 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Morita H,Tanaka K,Hosomi H: "Chemical inactivation of the nucleus tractus solitarius abolished hepatojejunal reflex in the rats." Journal of the Autonomic Nervous System. 48. 207-212 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Murakami H,Takeda T,Kagawa K,Morita H,Tanaka S,Hosomi H: "The role of extrinsic nervous system in jejunal absorption during elevation of intraluminal pressure in anesthetized dogs" Journal of the Autonomic Nervous System. 51. 237-244 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Morita H,Matsuda T,Tanaka K,Hosomi H: "Role of hepatic receptors in controlling body fluid homeostasis." Japanese Journal of Physiology. 45. 355-368 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary

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Published: 1994-04-01   Modified: 2016-04-21  

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