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Central peptidergic regulatory mechanims of sympatho-adrenomedullarly functions.

Research Project

Project/Area Number 06670115
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field General pharmacology
Research InstitutionKochi Medical School

Principal Investigator

OSUMI Yoshitsugu  Kochi Medical School Pharmacology Professor, 医学部, 教授 (80025634)

Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1994: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsSympathetic Nerve / Adrenal Medulla / Bombesin / Prostaglandin / Noradrenaline / Adrenaline / Interleukin-1beta
Research Abstract

Central regulatory mechanisms of sympatho-adrenomedullaryl functions were examined in rats under urethane anesthesia. Results obtained are as follows : Intracerebroventricular (ICV) administration of bombesin elevated plasma levels of both noradrenaline (NA) and adrenaline (Ad), and nerve activities electrically recorded form both the sympathetic and adrenal branches of the splanchinic nerves. On the other hand, prostaglandin (PG) E2 by the same route selectively elevated the plasma level of NA alone, and nerve activity of the sympathetic but not the adrenal branch. 2) The effect of PGE2 to elevate the plasma level of NA was due to its activation of EP3 receptors in the brain. 3) Interleukin 1beta (IL-1beta), a madiator of immune signals, selectively elevated the plasma level of NA but not AD,as observed with PGE2.4) The effects of bombesin and IL-1beta on the plasma levels of NA and Ad were abolished by ICV pretreatment with indomethacin, an inhibitor of PG synthesis. 5) From the results with L-NAME,an inhibitor of nitric oxide (NO) synthetase, and exyhemoglobin, an NO scavenger, NO produced in the brain by IL-1beta probably mediates this cytokine-induced elevtion of plasma level of NA.
From these results, it is suggested that two different types of neuronal cells probbly exist in the brain ; activation of one neuronal cell group ecxites both the sympathetic and adrenomedullarly systems, while activation of the other neuronal cell group selectively excites the sympathetic system alone. Receptors of bombesin are located on the former neuronal cell group, while those of IL-1beta are located on the latter neuronal cell group in the brain. PGs in the brain produced by bombesin and IL-1beta are probably involved in activation of these neuronal cell groups.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] Yasunobu Okuma: "Centrally applied bombesin increases nerve activity of both sympathetic and adrenal branch of the splanchnic nerves." Japanese Journal of Pharmacology. 68. 227-230 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kunihiko Yokotani: "Elevation of plasma noradrenaline levels in urethane-anaesthetized rats by activation of central prostanoid EP_3 receptors." British Journal of Pharmacology. 115. 672-676 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yasunobu OKUMA,Kunihiko YOKOTANI and Yoshitsugu OSUMI.: "Centrally applied bombesin increases nerve activity of both sympathetic and adrenal branch of the splanchnic nerves." Jpn. J.Pharmacol.68. 227-230 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kunihiko YOKOTANI,Makoto NISHIHARA,Yoshinori MURAKAMI,Takashi HASEGAWA,Yasunobu OKUMA and Yoshitsugu OSUMI.: "Elevation of plasma noradrnaline levels in urethane-anaesthetized rats by activation of central prostanoid EP3 receptors." Br. J.Pharmacol.115. 672-676 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yasunobu Okuma: "Centrally applied bombesin increases nerve activity of both sympathetic and adrenal branch of the splanchnic nerves." Japanese Journal of Pharmacology. 68. 227-230 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kunihiko Yokotani: "Elevation of plasma noradrenaline levels in urethane-anaesthetized rats by activation of central prostanoid EP_3 receptors." British Journal of Pharmacology. 115. 672-676 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yokotani,K.,Osumi,Y.et al.: "Activation of central prostanoid EP3 receptors elevates plasma noradrenaline levels in urethane-anesthetized rats." British Journal of Pharmacology. (in press). (1995)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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