| Project/Area Number |
06670372
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | The University of Tsukuba |
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Principal Investigator |
SHIMOJO Nobuhiro Institute of Community Medicine, The University of Tsukuba proffesor, 社会医学系, 教授 (00080622)
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| Project Period (FY) |
1994 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1996: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1994: ¥600,000 (Direct Cost: ¥600,000)
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| Keywords | SR-XRF / smelter / hair / heavy metals / biological monitoring / time lag / SOD / methylmercury / 金属精錬工場 / 非破壊放射光蛍光X線分析 / 2次元イメージング / 金属精錬労働者 / 金属 / 金属精錬 / 労働者 / 生物学的モニタリング / 鉛 / 亜鉛 / 銅 |
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| Research Abstract |
The result of the studies carried out for three years, 1994 to 1996, can be summarized as follows.
1) In this study, we attempted to perform the X-ray microanalysis, ie, one pixel is 5*5mum^2, to reveal trace element distribution of human hair cross sections without washing the samples. The SR-XRF imaging technique used in this study clearly revealed differential distribution of Zn and Pb in the cross hair secton of the smelter.
2) A study of alterations in mammalian Cu, Zn- and Mn-superoxide dismutase caused by methylmercury has been reviewed. Mechanisms for the isozyme-elective decrease in Mn-SOD by the organometallic compound observrd in vivo has been extensively examined by experiments with purified enzyme preparations.
3) The metal leveals in blood and hair reached a maximum at 7 and 8.5 days, respectively, but these elimination curves exhibited a similar pattern (r=0.97) with a time lag (about 3.5 days).
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