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A BASIC STUDY ON INVESTIGATION INTO FOOD ALLERGY OF UNIVERSITY STUDENTS BY QUESTIONNAIRE AND THE CAUSATIVE FOODS

Research Project

Project/Area Number 06670420
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Public health/Health science
Research InstitutionTHE UNIVERSITY OF TOKUSHIMA

Principal Investigator

MINATO Yoshihiro  TOKUSHIMA UNIVERSITY,SCHOOL OF MEDICINE,PROFESSOR, 保健管理センター, 教授 (00035768)

Co-Investigator(Kenkyū-buntansha) KOGA Tetsuro  TOKUSHIMA UNIVERSITY,SCHOOL OF MEDICINE,RESEARCH ASSOCIATE, 医学部, 助手 (20093859)
YAMATO Masayuki  TOKUSHIMA UNIVERSITY,SCHOOL OF MEDICINE,RESEARCH ASSOCIATE, 医学部, 助手 (90210492)
SHIMA Kennji  TOKUSHIMA UNIVERSITY,SCHOOL OF MEDICINE,PROFESSOR, 医学部, 教授 (90028407)
OTA Fusao  TOKUSHIMA UNIVERSITY,SCHOOL OF MEDICINE,PROFESSOR, 医学部, 教授 (90035478)
大澤 朗  徳島大学, 医学部, 助手 (10253189)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1995: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1994: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsFood allergy / Questionnaire / Glucose Intolerance / Students / Atopy / Tokushima university / IgE / Medical examination
Research Abstract

The prevalence of food allergy and/or intolerance (FA/FI) were studied in a large samples of students at the university of Tokushima, Tokushima, Japan. The survey was carried out on self-reported FA/FI investigated by questionnaire which was conducted at the annual medical examination. In the first year (1994) a total of 1853 students consisting of 1300 male and 553 female was examined. It was found that only 2.5 male students and 2.9 female students had been told by medical doctors prior to the questionnaire. A statistically significant difference was found between male and female subject in the number of those who experienced allergic episodes due to food allergy. Causative foods were milk and milk products, meat, cereals, vegetables and others including coffee. Some students were considered to suffer from glucose intolerance. No significant relationship was observed between the likes or dislikes and the kind of causative foods.
Sera collected at the questionnaire were tested for quan … More tification of IgE by enzyme immunoassay using a commercial kit. Attempts were made to obtain the optimal conditions for EIA.
In the second year (1995), a total of 3025 of students belonging to The University of Tokushima was asked to report their episodes of food allergy and other related diseases by means of questionnaire at the time of their annual medical examination. Out of 3025 only 53 students were found to be of incompliance due to rejection for unknown reasons. Only a total of 99 students reported to have experienced reliable episodes of food allergy. The prevalence was about 26%. NO statistically significant difference was found between male and female group of students in the prevalence. Causative foods were in order milk and milk products, sea foods, cereals, vegetables and others including coffee. Other observations were similar to those obtained in 1994.
Sera obtained from a test group of students having positive food allergy based on questionnaire were also examined for quantification of IgE using an automatic EIA analyzer (Poseidon II model AEC 2000, Aloka, Tokyo). The control group involved sera collected from students without no episode of any disease entities nor injury in the questionnaire. It was found that the positive group showed statistically higher titres than those in the control group.
It was felt that continuous investigation was needed to validate these observations. Less

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] Ota,F.,et al.,: "Immunochemical study of polysaccharide antigen in St.sobrinus and St.downei with a cross-reactive monoclonal antibody." FEMS Immunol.& Med.Microbiol.,. 8. 213-218 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ono,T.,et al.,: "Detection of Streptococcus mutans by PCR amplification of spaP gene." J.Med.Microbiol.,. 41. 231-235 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yamato,M.,et al.,: "Monoclonal antibodies to spirosin of Yersinia enterocolitica and analysis of the localization of spirosome by use of them." Microbiol.Immunol.,. 38. 177-182 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 大栗美保、他: "大学生の食事アレルギー調査と原因抗原物質に関する基礎的研究第一報 食事アレルギー調査の集計結果" 日本栄養・食糧学会誌講演要旨集. 178- (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ota,F.,et al.,: "Immunochemical analysis and localization of a cell wall antigen of Streptococcus rattus with a specific monoclonal antibody." Zbl.Bakt.,. 282. 343-352 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 大和正幸、他: "分子遺伝学的手法を利用したS.mutansの同定" 日本細菌学雑誌. 50. 255- (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 高木篤編、斎藤肇、他著: "エッセンシャル微生物学" 医歯薬出版株式会社(印刷中), 740 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 大森俊彦、太田房雄、秋本茂、著: "微生物学" 朝倉書店, 315 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Shuji Suzuki: "The Pathogenesis of Allergy" Research in Food Hygiene. 44. 7-15 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ooguri Miho, Masahide Imaki, Minato Yoshihiro, Ishikawa Hiroyuki, Takeoka Aya, Ota Fusao: "A basic study on food allergy of university students and causative foods. (1st report) Results of a survey on food allergy." Annual Meeting of the Japanese Society for Nutrition and Food Science April 19th-21st 1995, Gifu.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] J.J.N.Jansen, A.F.M., Kardinal, G.Huijeberes, B.J.Vlieg-Boerstra, B.P.M.Martens, and T.: "Ockhuizen Prevalence of food allergy and intolerance in the adults Dutch population" J.Aller.Clin.Immunol. 93. 446-456 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] J.A.Mcloughlin et al.: "teacher opinion of the role of food allergy on school behavior and achievement" annals of Allergy. 61. 89-91 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] W.P.Mcwhorter: "Allergy and risk of cancer." A prospective study using HHANESI follow-up Data.Cancer 62. 451-455 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Fusao Ota, Hideaki Nagamune, Ken Nemoto, Komei Fukui and Nagayuki Yoshida, Katsuhiko Hirota, Michinori Kusuda, Terushige Kawata and Yoshihiro Minato.: "Studies on the immunological specificity of streptococci by use of monoclonal antibodies. I.Selection of EIA plates and conditions for the use of polysaccharide antigens." Shikoku Acta Medica. 45. 245-255 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Hideaki Nagamune, Fusao Ota, Komei Fukui and Nagayuki Yoshida, Katsuhiko Hirota, Terushige Kawata and Yoshihiro Minato: "Studies on the immunological specificity of streptococci by use of monoclonal antibodies. II.Selection of EIA microtitre plates for the immunological analysis of streptococcal whole cells." Shikoku Acta Medica. 45. 256-264 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Part II Clinical practice, Chapter 11-27. in "Allergy, Ed.by Holgate S.T., M.K.Church, and K.F.Austin. Gower Medical Publishing, London・New York, (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ota, F., et al.,: "Immunochemical analysis and localization of a cell wall antigen of Streptococcus rattus with a specific monoclonal antibody." Zbl. Bakt.,. 282. 343-352 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 大和正幸、他: "分子遺伝学的手法を利用したS.mutansの同定" 日本細菌学雑誌. 50. 255- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 大栗美保、他: "大学生の食事アレルギー調査と原因抗原物質に関する基礎的研究 第一報 食事アレルギー調査の集計結果" 日本栄養・食糧学会誌講演要旨集. 178- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 高木篤編、斎藤肇、他著: "エッセンシャル微生物学" 医歯薬出版株式会社(印刷中), 740 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 大森俊彦、太田房雄、秋本茂、著: "微生物学" 朝倉書店, 315 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ota,F.,他: "Immunochemical study of polysaccharide antigen in St.sobrinus and St.downei with a cross-reactive monoclonal antibody." FEMS Immunol.& Med.Microbiol.,. 8. 213-218 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ono,T.,他: "Detection of Streptococcus mutans by PCR amplification of spaP gene." J.Med.Microbiol.,. 41. 231-235 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Yamato,M.,他: "Monoclonal antibodies to spirosin of Yersinia enterocolitica and analysis of the localization of spirosome by use of them." Microbiol.Immunol.,. 38. 177-182 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 岡田 要、他: "Streptococcus mutansによる実験腎炎" 日本小児腎臓病学会雑誌. 7. 82-85 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ota,F.,他: "Immunochemical analysis and localization of a cell wall antigen of Streptococcus rattus with a specific monoclonal antibody." Zbl.Bakt.,. (印刷中). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 大和 正幸、他: "分子遺伝学的手法を利用したS.mutansの同定" 日本細菌学雑誌. 50(印刷中). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 高木 篤編、斉藤 肇、他著: "エッセンシャル微生物学" 医歯薬出版株式会社(印刷中), 740 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 大森 俊彦、太田 房雄、秋本 茂、著: "微生物学" 朝倉書店, 315 (1995)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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