| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1994: ¥600,000 (Direct Cost: ¥600,000)
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| Research Abstract |
To evaluate the efficacy of lipid screening in Japanese children, blood samples were obtained for the determination of fasting levels of serum total cholesterol (TC), triglycerides (TG) and high-density lipoprotein cholesterol (HDL) in 902 children, aged 6-14 years (1st to 9th graders) residing in a semirural town. Parental and grand-parental histories of premature cardiovascular diseases (CVD) were also obtained. Thirty-seven (14%) of the 1-3rd, 47 (16%) of the 4-6th, and 48 (14%) of the 7-9th graders had family history of CVD.
Among them, 8 (22%) of the 1-3rd, 9 (19%) of the 4-6th, and 4 (8%) of the 7-9th graders had one or more abnormal lipid value : TC*200 mg/dl, TG*160 mg/dl, low density lipoprotein cholesterol {= TC- (HDL+TG/5}*130 mg/dl, HDL*40 mg/dl, or atherogenic index{= (TC-HDL) /HDL)}*3.0. On the other hand, 58 (28%) of the 1-3rd, 47 (20%) of the 4-6th and 16 (7%) of the 7-9th graders without family history of CVD had one or more abnormal lipid value.
These findings raise the same questions as in the western countries about the targeted screening as a initial step to indentify children with abnormal lipid values.
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