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In vivo effects of sIL-IR and sIL-4R on IgE production and regulation of allergic reaction

Research Project

Project/Area Number 06670498
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 内科学一般
Research InstitutionJuntendo University School of Medicine

Principal Investigator

MIYAJIMA Hiroaki  Juntendo University School of Medicine, Immunology, Assistant Prof., 医学部, 助手 (80209907)

Co-Investigator(Kenkyū-buntansha) OKUMURA Ko  Juntendo University School of Medicine, Immunology, Prof., 医学部, 教授 (50009700)
HIRANO Takao  Juntendo University School of Medicine, Intermedicine, Associate Prof., 医学部, 助教授 (10165186)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1994: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordssIL-1R / sIL-4R / IgE / GVHD / IgE / IL-1レセプター / IL-4レセプター / 可溶性IL-4リセプター / 可溶性IL-1リセプター / IgG1
Research Abstract

The effect of sIL-4R and IL-1R were carried out on IgE production or murine GVHD models in vivo and in vitro.
The effect of sIL-4R : IL-4 dependent cell line (CTLL-2) were cultured with sIL-4R and IL-4, CTLL-2 was inhibit. However, IgE production in mice infected with Nb. was not suppressive by the injection of sIL-4R in vivo.
The effect of sIL-1R : Induction of GVH reaction in irradiated (BALB/c x C57BL/6)F1(CBF1) with bone marrow cells (BMC) plus spleen cells of (C57BL/6, or BALB/c) lead to GVHD (BMT/GVHD). The use of donor as BALB/c induced chonic GVHD whereas taht as C57BL/6 induced acute GVHD.When in murine acute GVHD model mice were treated with sIL-1R but sIL-4R, oranic falure of liver disease, splenomegaly and Immunodysfuncitons of T cell maturations were improved in GVHD mice.
In our studies :
1) sIL-4R were effective to suppression of IgE productions and inhibition of CTLL-2 cells.
2) sIL-1R were effective to improvement of acute GVHD in mice.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Ushiyama C.: "Anti-IL-4 antibody prevents a Graft-versus-Host diseaes (GVHD) in mice after bone marrow transplantation (BMT) : IgE allotype is an important marker of GVHD." J.Immunol.154. 2687-2696 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yamada M.: "Construction of a monoclonal antibody against Igh-7b." Immunogenetics. 40. 296-299 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takai S.: "Increased IgE level as a marker of host versus graft desease : inhibition of this HVGD with a monoclonal antibody to IL-4." Cell Immunol.149. 1-10 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Usui M.: "Construction of a monoclonal antibody to Igh-7a." Immunogenetics. 37. 301-304 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 平野隆雄: "GVHDのマウスモデル" 血液腫瘍. 31. 327-333 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 平野隆雄: "輸血後GVHDマウスにおける免疫学的解析" 日本臨床免疫学会会誌. 17. 961-966 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ushiyama, C.: "Anti-IL-4 antibody prevents a Graft-versus-Host diseases (GVHD) in mice after bone marrow transplantation (BMT) : IgE allotype is an important marker of GVHD." J.Immunol. 154. 2687-2696 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yamada, M: "Construction of a monoclonal antibody against IgH-7b." Immunogenetics. 40. 296-299 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takai, S: "Increased IgE level as a marker of host versus graft desease : inhibition of this HVGD with a monoclonal antibody to IL-4." Cell immunol.149. 1-10 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Usui, M: "Construction of a monoclonal antibody to Igh-7a." Immunogenetics.37. 301-304 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ushiyama,C: "Anti-IL-4 antibody prevents a Graft-versus-Host disease (GVHD) in mice after bone marrow transplantation (BMT) : IgE allotype is an important marker of GVHD." J. Immunol.154. 2687-2696 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yamada,M: "Construction of a monoclonal antibody against Ign-7b." Immunogenetics. 40. 296-299 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Takai,S: "Increased IgE level as a marker of host versus graft desease: inhibition of this HVGD with a monoclonal antibody to IL-4." Cell Immunol.149. 1-10 (1993)

    • Related Report
      1995 Annual Research Report
  • [Publications] Usui,M.: "Construction of a monoclonal antibody to Igh-7a." Immunogenetics. 37. 301-304 (1993)

    • Related Report
      1995 Annual Research Report
  • [Publications] 平野隆雄: "GVHDのマウスモデル" 血液腫瘍. 31. 327-333 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 平野隆雄: "輸血後GVHDマウスにおける免疫学的解析" 日本臨床免疫学会会誌. 17. 961-966 (1994)

    • Related Report
      1995 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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