| Project/Area Number |
06670498
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
内科学一般
|
|---|
| Research Institution | Juntendo University School of Medicine |
|---|
Principal Investigator |
MIYAJIMA Hiroaki Juntendo University School of Medicine, Immunology, Assistant Prof., 医学部, 助手 (80209907)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OKUMURA Ko Juntendo University School of Medicine, Immunology, Prof., 医学部, 教授 (50009700)
HIRANO Takao Juntendo University School of Medicine, Intermedicine, Associate Prof., 医学部, 助教授 (10165186)
|
|---|
| Project Period (FY) |
1994 – 1995
|
| Project Status |
Completed (Fiscal Year 1995)
|
| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1994: ¥1,000,000 (Direct Cost: ¥1,000,000)
|
|---|
| Keywords | sIL-1R / sIL-4R / IgE / GVHD / IgE / IL-1レセプター / IL-4レセプター / 可溶性IL-4リセプター / 可溶性IL-1リセプター / IgG1 |
|---|
| Research Abstract |
The effect of sIL-4R and IL-1R were carried out on IgE production or murine GVHD models in vivo and in vitro.
The effect of sIL-4R : IL-4 dependent cell line (CTLL-2) were cultured with sIL-4R and IL-4, CTLL-2 was inhibit. However, IgE production in mice infected with Nb. was not suppressive by the injection of sIL-4R in vivo.
The effect of sIL-1R : Induction of GVH reaction in irradiated (BALB/c x C57BL/6)F1(CBF1) with bone marrow cells (BMC) plus spleen cells of (C57BL/6, or BALB/c) lead to GVHD (BMT/GVHD). The use of donor as BALB/c induced chonic GVHD whereas taht as C57BL/6 induced acute GVHD.When in murine acute GVHD model mice were treated with sIL-1R but sIL-4R, oranic falure of liver disease, splenomegaly and Immunodysfuncitons of T cell maturations were improved in GVHD mice.
In our studies :
1) sIL-4R were effective to suppression of IgE productions and inhibition of CTLL-2 cells.
2) sIL-1R were effective to improvement of acute GVHD in mice.
|
