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Alterations of biliary lipid composition in patients with fatty liver and those with cholesterol gallstone disease

Research Project

Project/Area Number 06670519
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionUniversity of Tsukuba

Principal Investigator

SHODA Junichi  Institute of Clinical Medicine, University of Tsukuba, Assistant Professor, 臨床医学系, 講師 (90241827)

Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1995: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1994: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywordscholelithiasis / cholesterol / bile acid / gallbladder emptying / small intestinal transit / 過栄養性脂肪肝 / コレステロール胆石症 / コレステロール過飽和胆汁 / コレステロール代謝 / 胆汁酸代謝
Research Abstract

Formation of cholesterol supersaturated bile is a prerequisite for cholesterol gallstone disease. In order to elucidate mechanisms responsible for cholesterol supersaturated bile formation in patients with cholesterol gallstone disease, we focused on the motility of the gallbladder and small intestine, both of which are important in maintaining enterohepatic circulation of bile acids, in addition to the hepatic cholesterogenesis and bile acid synthesis. In gallstone patients with intact gallbladder emptying, the small intestinal transit and absorption of bile acids were not prolonged and impaired, as compared with control subjects. Therfore, the patients may not exhibit the characteristics of a decrease in circulating pool of bile acids, and accordingly their gallbladder bile does not become supersaturated with cholesterol. However, in patients with impaired gallbladder emptying, the small intestinal transit and absorption of bile acids were significantly prolonged and impaired. In such cases, the supersaturation of gallbladder bile may be due to the reduced pool of circulating bile acids brought about by changes in bile acid distribution, e.g., a sequestration into the hypomotile gallbladder and intestine. In gallstone patients, hepatic de novo cholesterol synthesis was significantly decreased as compared with control subjects. it is further suggested that in the formation of cholesterol supersaturated bile a hypersecretion of cholesterol derived from an exogeneous source may play a significant role.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Shoda J, He B, Tanaka N, Matsuzaki Y, Osuga T, Yamamori S, Miyazaki H, Sjovall J.: "Increase of deoxycholate in supersaturated bile of patients with cholesterol gallstone disease, and its correlation with denovo……" Hepatology. 21. 1291-1302 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Shoda J, He B, Tanaka N, Matsuzaki Y, Yamamori S, Osuga Y.: "Primary dual defect cholesterol and bile acid metabolism in Ziven of patients with intrahepatic calculi." Gastroenterology. 108. 1534-1546 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Shoda J,He B,Tanaka N,Matsuzaki Y.Osuga T,Yamamori S,Miyazaki H,Sjovall J: "Increase of deoxycholate in supersaturated bile of patients with cholesterol gallstone diseases and its correlation with de novo syntheses of cholesterol and bile acids in liver, gallbladder emptying, and small intestinal transit" Hepatology. 21. 1291-1302 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Shoda J, et al.: "Plasma levels of mevalonate and 7d-hydroxy-4-cholesten-3-one in cholesterol gallstone disease and their etiological significance" Journal of Gastroenterology. 29. 94- (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Shoda J, et al.: "Novel steroz 7d-hydroxylase(s), microsomal 27-hydroxycholesterol 72-hydroxylase, in cholesterol gallstone disease and its etiological significance" Journal of Gastroenterology. 29. 241- (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yoshida T, et al.: "Deternination of 72-hydroxy-4-cholesten-3-one level in human plasma using isotope-dilution mass spectrometry and monitoring its circadian rhythm in human" Journal of Chromatography. 655. 179-187 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Honda A, et al.: "Increased bile acid concentration in lover tissue with cholesterol gallstone disease" Journal of Gastroenterology. 30. 61-65 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Shoda J, et al.: "Increase of deoxycholate in supersaturated bile of patients with cholesterol gallstone disease, and its correlation with denovo syntheses of cholesterol" Hepatology. 21. 1291-1302 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Shoda J, et al.: "Promany dual defect of cholesterol and bile acid metabolism in lover of patrents with intrahepatic calculi" Gastroenterology. 108. 1534-1546 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Honda A, et al.: "Accumlation of 72-hydroxycholesterol in liver tissue from cholesterol gallstone patcents" Journal of Gastroenterology. 30. 651-656 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Yoshida T, et al.: "Determination of 7α-hydroxy-4-cholesten-3-one level in human plasma using isotopedilution mass spectrometry and monitoring its circadian rhythm in human as an index" Journal of Chromatography Biomedical Application. 655. 179-187 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Honda A, et al.: "Increased bile acid concentration in liver tissue with cholesterol gallstone disease." Journal of Gastroenterology. 30. 61-66 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Axelson M, et al.: "Structual specificity in the suppression of HMG-CoA reductase in human fibroblasts by intermediates in bile acid biosynthesis." Journal of Lipid Research. (in press).

    • Related Report
      1994 Annual Research Report
  • [Publications] Shoda J, et al.: "Increase of deoxycholate in supersaturated bile of patients with cholesterol gallstone disease, and its correlation with de novo syntheses of cholesterol and bile acids in" Hepatology. (in press).

    • Related Report
      1994 Annual Research Report
  • [Publications] Shoda J, et al.: "Primary dual defect of cholesterol and bile acid metabolism in liver of patients with intrahepatic calculi." Gastroenterology. (in press).

    • Related Report
      1994 Annual Research Report
  • [Publications] Honda A, et al.: "Accumulation of 7α-hydroxycholesterol in liver tissue from cholesterol gallstone patients." Journal of Gastroenterology. (in press).

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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