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原発性胆汁性肝硬変におけるHLA DR8を介した胆管抗原p28の抗原呈示

Research Project

Project/Area Number 06670561
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionKochi Medical School

Principal Investigator

大西 三朗  高知医科大学, 医学部, 助教授 (60136380)

Co-Investigator(Kenkyū-buntansha) 前田 隆  高知医科大学, 医学部, 助手 (80183606)
西原 利治  高知医科大学, 医学部, 講師 (60145125)
Project Period (FY) 1994
Project Status Completed (Fiscal Year 1994)
Budget Amount *help
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1994: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywords原発性胆汁性肝硬変 / 免疫遺伝 / 胆管上皮抗原
Research Abstract

1)原発性胆汁性肝硬変(PBC)の疾患感学性遺伝子についてDNA-typingを用いて解析した。その結果MHC class II DR8遺伝子がPBCの発症に関連する事を明らかにした。DRB1*0803が中でも高率に検出された。MHC近傍遺伝子のうちTumor necrosis factor-αのNCo1多型性,およびTAP遺伝子のTAP2多型性はPBCと健常者で有意差を認めなかった。
2)PBCのTcell免疫応管の標的抗原の一つであるヒト胆汁蛋白抗原p28のAA seguenceは今回は沢山出来なかった。しかしPBCの抹消血由来Tリンパ球の増殖反応はDR8陽性患者でhigh response,DR8陰性者でlow responseを示した。

Report

(1 results)
  • 1994 Annual Research Report
  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] T.Saibara et al: "Acute nepatic failure with swollen mitochondria and microvesiculan fatty degeneration of nepato cytes triggered by free radical initiator" Laboratory Investigation. 70. 517-524 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] H.Enzan et al: "α-smooth muscle actin-positive perisinusoidal stroma cells in numan nepatocellular carcinoma" Hepatology. 19. 895-903 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] H.Takanashi et al: "Serum α-L-fucosidase activity and tumor size in nepatocellulan carcinoma" Hepatology. 19. 1414-1417 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] S.Iwamura et al: "Appearance of sinusoidal inclusion-containg endothelial cell in liver disease" Hepatology. 20. 604-610 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] S.Onishi et al: "DNA typing of HLA class II genes; DRB1*0803 increases the susceptibility of Japanese to primary bilialy cirrhosis" J Hepatology. 21. 1053-1060 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] H.Himeno et al: "Integrin common-chain beta-1 immunoreactivity in hepatocellular carcinoma" J.Pathology. 172. 363-363 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 大西三朗: "消火器病セミナー54 原発性胆汁性肝硬変・病態・治療・予後" へるす出版, 181 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 大西三朗: "肝胆膵研究の進歩 第2輯" 国際医書出版, 289 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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