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Apolipoprotein Phenotypes in Healthy Controls and Demented Patients from the Inhabitants in the middle and Northern mie Prefecture of Japan

Research Project

Project/Area Number 06670650
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionMie University

Principal Investigator

KUZUHARA Shigeki  Mie university Hospital Department of Neurology, Professor, 医学部附属病院, 教授 (70111383)

Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1995: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1994: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsApolipoprotein E4 / Alzheimeriedissari / dementia / risk Factor / アポリポ蛋白E / 老年痴呆 / 脳血管性痴呆 / 血清診断
Research Abstract

To clarify the association of apolipoprotein E4 (apo E4) with the pathognenesis of Alzehimer's disease (AD) , we analyzed the distribution of apolipoprotein E (apo E) phenotype and the ealculated the frequency of epsilon2, epsilon4 of 692 healthy controls and 75 demented patients from the inhabitants in the middle and nothern areas of Mie Prefecture of Japan.
Demented subjects included 13 patients with early onset Alzheimer's desease group (EOAD) , 30 patients with late onset Alzheimer's disease group (LOAD) , and 30 patients with vascular dementia group (VD). The apolipoprotein E phenotype was determined by the isoelectric focusing and immunoblotting. The_X^2 test was used in statical analysis.
There were no significant differences between sexes or among ages in the frequency of each apo E phenotype, and the estimated frequency of epsilon2, epsilon3, and epsilon4 was 0.05,0.85 and 0.10 respectively in normal and elderly controls. There was a significant difference in the frequency of apo E phenotypes between the patients with LOAD and elderly controls aged 60 years or older (p<0.0001) , but there was no statiscal difference between the elderly controls and EOAD or VD group. The frequency of epsilon3 was 0.77 in EOAD,0.60 in LOAD and 0.81 in VD,and the frequency of epsilon4 was 0.19 in EOAD,0.38 in LOAD and 0.13 in VD.In the patients with LOAD,epsilon3 frequency was significantly lower (p<0.0001) and epsilon4 frequency was significantly higher (p<0.0001) than that in the controls.
The frequency of apo E4 was significantly high in patients with LOAD,and the apo E4 is a possible candidate of one of the risk factors of development of LOAD.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] 葛原茂樹: "神経原線維変化とアルツハイマー型痴呆" Dementia. 8(1). 58-64 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 葛原茂樹: "前頭葉型痴呆と脳,血管性痴呆." 老年精神医学雑誌. 5(7). 813-820 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 葛原茂樹: "変性性、血管性、混合性痴呆の病態生理" 綜合臨床. 44(5). 813-820 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 葛原茂樹: "神経難病および周辺疾患、老年痴呆" 綜合臨床. 44. 2617-2622 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 葛原茂樹: "汎発性Lewy小体病と痴呆" 老年期痴呆研究会誌. 8. 113-117 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 葛原茂樹: "知能障害の臨床像;神経内科の立場より" Clin neurosci. 14(1). 71-73 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kuzuhara, S: "Alzheimer neurofibrillary changes and dementia of Alzeimer type." Dementia. 8. 58-64 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kuzuhara, S: "Degenerative, vascular and, mixed type dementia." Soh-Goh Rinsho. 44. 813-820 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kuzuhara, S: "Senile dementia of Alzheimer type." Soh-Goh Rinsho. 44. 2617-2622 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kuzuhara, S: "Diffuse Lewy body disease and dementia." J Senile Dementia.8. 113-117 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kuzuhara, S: "Clinical features of dementia in neurological disorders." Clin Neurosci. 14. 71-73 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kuzuhara, S: "frontal type dementia and vascular dementia." Proceedings of the Annual meeting of the Japanese Research Group on senile Dementia. 5. 813-820 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 葛原茂樹: "脳血管性痴呆の診断と治療." 循環. 16(3). 12-17 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 葛原茂樹: "変性性・血管性・混合性痴呆の病態生理." 綜合臨床. 44(5). 813-820 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 葛原茂樹: "Alzheimer型痴呆の診断基準・病型分類・重症度." 内科. 75(6). 1341-1343 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 葛原茂樹: "神経難病および周辺疾患;老年痴呆." 総合臨床. 44. 2617-2622 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 葛原茂樹: "汎発性Lewy小体病と痴呆." 老年期痴呆研究会誌. 8. 113-117 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 葛原茂樹: "知能障害の臨床像;神経内科の立場より." Clin Neurosci. 14(1). 71-73 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] 葛原茂樹: "「新筋肉病学」 筋萎縮性側索硬化症." 南江堂 杉田秀夫、小澤英二郎、埜中征哉 編, 10 (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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