| Project/Area Number |
06670651
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | KYOTO UNIVERSITY |
|---|
Principal Investigator |
KAJI Ryuji Faculty of Medicine, Kyoto University Lecture, 医学研究科, 講師 (00214304)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KOHARA Nobuo Faculty of Medicine, Kyoto University Assistant, 医学研究科, 助手 (20252439)
KIMURA Jun Faculty of Medicine, Kyoto University Professor, 医学研究科, 教授 (10204976)
|
|---|
| Project Period (FY) |
1994 – 1995
|
| Project Status |
Completed (Fiscal Year 1995)
|
| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1994: ¥1,600,000 (Direct Cost: ¥1,600,000)
|
|---|
| Keywords | lymphokine / anti-GM1 antibody / conduction block / multifocal motor neuropathy / Guillan-Barre syndrome / Na Channel / single fiber recording / anti-GM1 antibody / multi focal motor neuropathy / Guillan-Barre syndrome / single fiber recording / multifocal motor neuropathy / T-cell / memhiane current |
|---|
| Research Abstract |
Antiganglioside antibodies are found in the axonal form of Guillain-Barre syndrome and multifocal motor neuropathy. Several studies indicated that they may produce conduction block through Na channel inactivation. To confirm this contention, we devised a method to analyze saltatory conduction in single myelinated fiber under the influence of the sera. Despite the premise, we found conduction block in only 2 out of 38 fibers examined with high-titer anti-GM1 rabbit serum. None showed conduction block by human sera. Only one out of 25 exhibited block after exposure to lymphokine produced by lymphocytes incubated with the anti sera. These finding do not support the view that these sera play an important role in the pathogenesis of these diseases.
|
