• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Role of Nitric Oxide in Regulation of Cerebral Circulation

Research Project

Project/Area Number 06670666
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionKeio University

Principal Investigator

AMANO Takahiro  Keio University, Department of Neurology, Assistant Professor, 医学部, 専任講師 (90118901)

Co-Investigator(Kenkyū-buntansha) GOTOH Jun  Keio University, Department of Neurology, Instructor, 医学部, 助手 (90245481)
MURAMATSU Kazuhiro  Keio University, Department of Neurology, Instructor, 医学部, 助手 (20230005)
OBARA Katsuyuki  Keio University, Department of Neurology, Instructor, 医学部, 助手 (40169363)
高橋 一司  慶應義塾大学, 医学部, 助手 (80236265)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1995: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1994: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsCerebral circulation / Nitric Oxide / Neurogenic Control / Chemical Control / Nitric Oxide / L-NMMA / L-Arginine
Research Abstract

The present study was undertaken to examine whether or not the NO system is involved in the regulation of cerebral blood flow. Mathod : Cats were anesthetized with an intraperitoneal injection of alpha-chloralose (50 mg/kg) and urethane (500mg/kg). Respiration was maintained by a Harvard respirator. The cranial window was placed in the skull on the left temporoparietal area. The window was used for monitoring pial vessels (A1 denotes the larger artery 100 mu in diameter) by a video camera system. Results : 1) The degree of arterial constriction by cervical sympathetic stimulation in the control group was not significantly different from that in the group during L-NMMA administration. The perivascular NO system does not modify the cerebral vasoconstriction elicited by cervical sympathetic nerves. 2) The pial arteries dilated by 10% CO_2 inhalation before L-NAME injection, but CO_2 reactivity indices of larger arteries significantly decreased at 60 minutes during L-NAME injection. Diated arteries only showed the suppression of CO_2 reactivity. The results indicate that diminution of CO_2 reactivity employing L-NAME is not due to NOS inhibition. 3) The autoregulatory response was evalated by the vasomotor index (VMI). VMI was calculated as the % change in diameter of pial vessels divided by the change of MABP in mmHg. The value of VMI (A1) were significantly decreased during the administration of L-NMMA.The decreased value of VMI returned to the control value after L-arginine administration. Therefore, NO in the endothelium seems to participate in autoreguratory response of cerebral vessels. Comments : The present investigations showed that the NO system has an important role in the regulation of autoregultoary response, but not in the chemical control by CO_2 inhalation.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] T Amano, Y Fukuuchi, K Obara et al:"Nitric oxide(NO)and sympathetic vasoconstriction" Stroke. 26. 179 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K Obara, Y Fukuuchi, T Amano et al:"Effects of nitric oxide synthase inhibitor L-NAME on CO2 reactivity of feline pial vessels" J Cereb Blood Flow and Metabol. 15(suppl !). S465 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T Amano, Y Fukuuchi, K Obara et al: "Nitric oxide (NO) and sympathetic vasoconstriction" Stroke. 26. 179 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K Obara, Y Fukuuchi, T Amano et al: "Effects of nitric oxide synthase inhibitor L-NAME on CO2 reactivity of feline pial vessels" J Cereb Blood Flow and Metabol 20GD02 : 15 (Suppl1). S465 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T. Amano et al: "Nitric oxide is inuolved in autoregulatory response of feline cerebral artery" The 18th salzburg conference Abstracts. p9- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 高橋、福内、天野ら: "脳循環自動調節とNitric oxide (NO)-CBV,血管口径変化による検討-" 脳循環代謝. 17. p98 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 天野隆弘: "内頸動脈病変は脳循環にどのような影響を与えるか-SPECTによる検討-" 脳管学. 35. 381-383 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] K. Obaray Y. Fukuuchi, T. Amano et al: "Effects of nitric oxide syuthase inhibitor L-NAME on CO_2 reactivety of feline pial vessels" Journal of Cerebral Blood Flow and Metabolism. 15 (suppl 1). S465- (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] TAMANO: "Nitric Oxide(NO) and Sympathetic Vasoconstriction" Stroke. 26. 179 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 天野 隆弘: "微小循環のCO_2反応性" 現代医療. 26. 1033-1038 (1994)

    • Related Report
      1994 Annual Research Report

URL: 

Published: 1994-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi