| Project/Area Number |
06670685
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | ASAHIKAWA MEDICAL COLLEGE |
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Principal Investigator |
YAMASHITA Hirohisa ASAHIKAWA MEDICAL COLLEGE,FIRST DEPARTMENT OF MEDICINE,ASSOCIATE PROFESSOR, 医学部, 助教授 (80041838)
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| Co-Investigator(Kenkyū-buntansha) |
HASEBE Naoyuki ASAHIKAWA MEDICAL COLLEGE,FIRST DEPAETMENT OF MEDICINE,RESEARCH ASSOCIATE, 医学部, 助手 (30192272)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1994: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | pulmonary circulation / vasoactive substance / metabolism / endocrine / paracrine / coronary flow / hemodynamics / ventricular geometry / paracrine, / hypoxic pulmonary vasoconstriction, |
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| Research Abstract |
Influence of pulmonary circulation to a regulation of systemic circulation was studied with special reference to metabolic and endocrinous functions of pulmonary vasculature, as a paracrinous effects to systemic circulation, and pharmacologic treatment of pulmonary embolic shock was olso studied with special reference to coronary flow and biventricular function. The metabolic function of pulmonary vasculature was reconfirmed with serotonin and PGF2a administration and endocrinous function was found by excretion of humoral mediator as four fold increase of c-AMP by isoproterenol and ten folds increase of PGE2 by pindolol in excised lung lobe perfusate. The paracrinous effects of pulmonary circulation to systemic organ circulation was examined by intravenous or intra-arterial administration of serotonin, and change in hemodynamics and coronary blood flow was observed. The increase in coronary blood flow by serotonin was observed, but there was no remarkable paracrinous effect from pulmonary circulation to coronary blood flow regulation, in this series. We also studied a role of medical therapy on pulmonary embolic shock using canine model. Isoproterenol or norepinephrine was administrated continuously in this model and each drug showed hemodynamic restoration initially. After that, norepinephrine endured the beneficial effect but isoproterenol lost hemodynamic improvements. The beneficial effect of norepinephrine was proved with restoration of coronary blood flow and biventricular geometry.
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