| Project/Area Number |
06670689
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | TOHOKU UNIVERSITY |
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Principal Investigator |
KOHZUKI Masahiro Tohoku University, School of Medicine Section of Internal Med & disability prevention Assistant Prof., 医学部(内部障害学), 助手 (70234698)
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| Co-Investigator(Kenkyū-buntansha) |
YASUJIMA Minoru Tohoku University, School of Medicine Dept. of Labo. Med. Prof., 医学部, 教授 (90142934)
ABE Keishi Tohoku University, School of Medicine Second Dept. of Med. Prof., 医学部, 教授 (60004777)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1994: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | Angiotensin / Angiotensin Converting enzyme / ACE inhibitor / Kinin / Losartan / Heart failure / Renal failure / Rat / losartan / erythropoietin / HOE140 |
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| Research Abstract |
1. We assessed the cardio- and reno-protective effects of three kinds of long-acting antihypertensive drugs in rats with chronic renal failure (CRF){an angiotensin II receptor antagonist, an ACE inhibitor, and a calcium channel blocker}. The results indicate that these long-acting antihypertensive drugs equally have the potency to protect heart and kidney in rats with CRF.
2. We assessed the potential of the kallikrein-kinin system in mediating the cardio-and reno-protective effects of ACE inhibitors in rats with chronic renal failure (CRF) using ACE inhibitors, a kinin antagonist and an AII receptor antagonist. These results indicate that the kallikrein-kinin system might not play a major role in the cardio-and reno-protective effects of ACE inhibitors in rats with CRF.
3. We assessed the cardiac and the renal benefit of an angiotensin II receptor antagonist, losartan, in diabetic rats with renal impairment. The results indicate the hypertension could accelerate diabetic renal impairment and that losartan has antihypertensive and renoprotective effects in this rat model. The difference in potency between losartan treatment and captopril treatment to attenuate the increase in heart weight : body weight ratio might partly explain the existence in the heart of abgiotensin-forming pathways, which are not dependent on angiotensin converting enzyme.
4. The effects of prolonged chlorothiazide (CTZ) treatment of left ventricular failure on cardiac hypertrophy, circulating vasoactive hormones and total exchangeable body sodium (NaE) were examined in rats with chronic myocardial infarction induced by left coronary artery ligation. CTZ does not cause regression of cardiac hypertrophy in rats with left ventricular failure and activates the renin angiotensin system.
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