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Dynamic intravenous coronary arteriography by using synchrotion radiation and its application to measuring coronary blood flow

Research Project

Project/Area Number 06670691
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionUniversity of Tsukuba

Principal Investigator

OHTSUKA Sadanori  Institute of Clinical Medicine University of Tsukuba, Lecturer, 臨床医学系, 講師 (40241814)

Co-Investigator(Kenkyū-buntansha) HYODO Kazuyuki  National Laboratory for High Energy Physics University of Tsukuba, Assistant, 測定器研究系, 助手 (60201729)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1994: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsSynchrotron radiation / Intravenous coronary arteriography / Coronary blood flow measurement / 冠血流計測法
Research Abstract

We have developed dynamic intravenous coronary arteriography (CAG) by using a two-dimensional X-ray beam from synchrotron radiation. We investigated the ability of dynamic intravenous CAG images to visualize the coronary arteries and to estimate coronary blood flow in animals.
We performed intravenous CAG in 10 dogs and one goat by using an intense, monochromatic (33.3KeV), two-dimensional X-ray beam, that was generated by asymmetrical reflection of synchrotron radiation from a silicon crystal. A contrast agent was injected through a catheter inserted into the inferior vena cava and the subject was irradiated with the X-ray beam. Images were obtained with a TV camera and were recorded on videotapes (33 images/sec).
In the dogs, we estimated blood flow in the left anterior descending coronary artery (LAD) from the CAG images by applying a transit-time analysis. Six dogs underwent thoracotomy and their LAD flow was measured with an electromagnetic flow probe. In 4 dogs, a perivascular Dopp … More ler flow probe that had been implanted a few weeks before the intravenous CAG was used to measure LAD flow velocity. Estimated LAD flow was compared with LAD flow actually measured.
The two-dimensional X-ray beam from synchrotron radiation permitted us to achieve dynamic intravenous CAG in the dogs and goat. Dynamic intravenous CAG images visualized clearly even an intentionally created coronary stenosis about 1 mm in length. In addition, coronary blood flow could be estimated from the dynamic CAG images with an acceptable degree of accuracy. LAD flow calculated from intravenous CAG was 14.7(]SY.+-.])5.1ml/min, whereas LAD flow measured with an electromagnetic flowmeter or ultrasound flowmeter was 16.6(]SY.+-.])4.8ml/min. There was a close correlation between the estimated and measured LAD flows (r=0.92, p<0.001).
Thus, dynamic intravenous CAG using synchrotron radiation is minimally invasive and permits the simultaneous evaluation of coronary anatomy and coronary blood flow. Clinical application of this procedure seems to be feasible. Less

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] Sadanori Ohtsuka: "Intravenous coronary angiography using a two-dimensional imaging system" Synchrotron Radiation News. 7. 21-22 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 大塚定徳: "放射光による冠動脈の形態面・機能面の非侵襲的同時評価" 興和生命科学振興財団研究報告. 6. 210-215 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 杉下靖郎: "放射光撮影のガイドライン" Japanese Circulation Journal (Suppl. III). 59. 947-948 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Sadanori Ohtsuka, Yasuro Sugishita, Kazuyuki Hyodo: "Intravenous coronary angiography using a two-dimensional imaging system" Synchrotron radiation news. 7 (6). 21-22 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Sadanori Ohtsuka, kazuyuki Hyodo, Yasuro Sugishita: "Real-time intravenous coronary arteriography with simultaneous measurement of coronary blood flow by using synchrotron radiation" Kowa Life Science Foundation Research Report. 6 (in Japanese). 210-215 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Yasuro Sugishita, Sadanori Ohtsuka: "Guideline of synchrotron radiation imaging" Japanese Circulation Journal. 59 (Suppl III) (in Japanese). 947-948 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Sadanori Ohtsuka: "Intravenous coronary angiography using a two-dimensional imaging system" Synchrotron Radiation News. 7. 21-22 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 大塚定徳: "放射光による冠動脈の形態面・機能面の非侵襲的同時評価" 興和生命科学振興財団研究報告. 6. 210-215 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 杉下靖郎: "放射光撮影のガイドライン" Japanese Circylction Journal(Suppl.III). 59. 947-948 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Sadanori Ohtsuka 他2名: "Intravenous Coronary Angiography Using a Two-Dimonsional Imaging System" Synchrotron Radiation News. 7. 21-22 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 大塚定徳 他2名: "放射光による冠動脈の形態面・機能面の非侵襲的同時評価" 興和生命科学振興財団「研究報告」. 6(in press). (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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