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^<31>P Chemical Shift Imaging for Quantitative Measurements of Cardiac High-Energy Phosphate

Research Project

Project/Area Number 06670711
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionShiga University of Medical Science

Principal Investigator

MITSUNAMI Kenichi  Faculty of Medicine, Associate Professor, 医学部, 助教授 (10127037)

Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1994: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywords^<31>P NMR spectroscopy / Chemical shift imaging / High-energy phosphate / Quantification / Human myocardium / Ischemic heart disease / Myochardial viability / MRS / 1D CSI
Research Abstract

The aims of this study were to determine whether or not quantitative measurements of cardiac high-energy phosphate by ^<31>P chemical shift imaging (CSI) are useful in assessing myocardial viability and to clarify which CSI technique is the most suitable. The one-dimensional CSI study group was composed of 41 patients with stenosis of the left anterior descending coronary artery (>50%) and 11 healthy control subjects (C). The patients were divided into two groups on the basis of exercise ^<201>Tl scintigraphy : a reversible ^<201>Tl defect group (RD [+] , N=29) and a fixed ^<201>Tl defect group (RD [-] , n=12). Cardiac ^<31>P magnetic resonance spectra were obtained by slice-selected one-dimensional CSI.For metabolite quantification a standard was placed at the center of the surface coil. ANOVA revealed significant differences among the three groups with respect to mean (<plus-minus>SD) phosphocreatine at rest (C,12.14<plus-minus>4.25>RD [+] , 7.64<plus-minus>3.00>RD [-] , 3.94<plus-mi … More nus>2.21 mumol/g wet heart tissue, p<0.05) as well as a significant decrease in ATP in the RD [-] group (C,7.72<plus-minus>2.97 ; RD [+] , 6.35<plus-minus>3.17>RD [-] , 4.35<plus-minus>1.52 mumol/g wet heart tissue, p<0.05). When a two-dimensional phase encoding technique with slice-selective excitation in the axial direction was used to measure the concentration of inorganic phosphate in the phantom, it yielded very accurate results. When the same technique, however, was applied to human heart, each voxel (2.5x2.5x2.5-cm^3) was often not totally filled with myocardium. This led to difficulties in estimating the myocardial weight in the voxel. It was impossible to place a standard within the sensitive volume of the surface coil when employing a two-dimensional phase encoding technique with slice-selective excitation in the coronal direction. Thus, one-dimensional CSI with sagittal slice-selective excitation is the most suitable CSI technique for cardiac metabolite measurements and is useful for the evaluation of myocardial viability. Less

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] 三ツ浪健一: "NMRスペクトロスコピーによる心筋虚血の診断" 別冊・医学のあゆみ 循環疾患-state of arts. 別冊. 256-258 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takahiro Yabe,Kenichi Mitsunami,Toshiro Inubushi,Masahiko Kinoshita: "Quantitative measurements of cardiac phosphorus metabolites in coronary artery disease by ^<31>P magnetic resonance spectoscopy" Circulation. 92. 15-23 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 三ツ浪健一,矢部隆宏: "心疾患診断における心臓MRSの適応と限界" 医学のあゆみ. 175. 72-77 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takahiro Yabe, Kenichi Mitsunami, Toshiro Inubushi, Masahiko Kinoshita: "Quantitative measurements of cardiac phosphorus metabolites in coronary artery disease by ^<31>P magnetic resonance spectroscopy" Circulation. 92 (1). 15-23 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kenichi Mitsunami, Takahiro Yabe: "In vivo human cardiac NMR spectroscopy" J.Clin.Exp.Med. (IGAKU NO AYUMI). 175 (1). 72-77 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takahiro Yabe: "Quantitative measurements of cardiac phosphorus metabolites in coronary artery disease by ^<31>P magnetic resonance spectroscopy" Circulation. 92. 15-23 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 三ッ浪健一: "心疾患診断における心臓MRSの適応と限界" 医学のあゆみ. 175. 72-77 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] 三ッ浪健一: "NMRスペクトロスコピーによる心筋虚血の診断" 別冊・医学のあゆみ 循環器疾患-state of arts. 別冊. 256-258 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Takahiro Yabe: "Quantitative Measurement of Cardiac Phosphorus Metabolites in Coronary Artery Disease by Phosphoras-31 Magnetic Resonance Spectroropy" Circulation. (in press) (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 三ッ浪健一: "MRSによる心筋虚血の診断" 現代医療. 27. 357-363 (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] 三ッ浪健一: "虚血性心疾患における心筋^<31>PMRS-心筋viabilityの評価-" 日本臨牀. 52増刊号. 530-535 (1994)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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