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Role of endothelium-derived nitric oxide on regulation of coronary blood flow

Research Project

Project/Area Number 06670730
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionKumamoto University

Principal Investigator

OKUMURA Ken  Kumamoto University, School of Medicine Assistant Professor, 医学部, 助教授 (20185549)

Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1995: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1994: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsEndothelium / Nitric Oxide / L-arginine / Coronary Circulation / L-Arginine
Research Abstract

To clarify the role of endotheliun-derived nitric oxide (EDNO) on regulation of coronary blood flow, we performed in-vivo study with anesthetized dogs. We have revealed that EDNO is likely to play a role in the regulation of the basal coronary blood flow (Arch int Pharmacodyn 1994 ; 327 : 251-265) , and the myocardial reactive hyperemia is regulated not only by adenosine but also by the EDNO.(Am J Physiol 1992 ; 263 : H8-H14、Cardiovascular Res 1996 in press) We also showed that when NO synthesis is inhibited, adenosine release is increased in response to themyocardial oxygen demand. With this compensatory adenosine release, coronary flow is increased and ventricular function is unaffected. (Am J Physiol 1996 ; 270 : H427-H434) Chronic inhibition of nitric oxide formation with oral administration of L-NAME,L-arginine analogue, blunted coronary reactive hyperemia, but didnot substantially impair the coronary blood flow associated with increased myocardial oxygen requirements produced by atrial pacing. We have revealed that adenosine is likely to play a role in this conpensation. (60th annual meeting of Japanese circulation society, 1996)

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] Tsunoda R, et al.: "Influence of the inhibition of endothelium-derived nitric oxide formation of the effects vasoconstrictor agents, neuropeptide Y, clonidine and ergonovine and ergonovine, on coronary vascular resistance." J Cadiovasc Pharmacol. 24. 87-94 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Matsunaga T, et al.: "Effect of cumulative dose of NG-intro-L-arginine methyl ester on coronary blood flow of anesthetized and conscious dogs." Arch Int Pharmacody. 327. 251-265 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tsunoda R, et al.: "Vasodilator Effect of Carboxy-2-Phenyl-4,4,5,5-Tetramethylimidasoline-1-Oxyl in the Coronary Circulation: in Vivo and in Vitro Studies." Eur. J. Pharmacol.47. 21-29 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tabuchi T. et al.: "Linear ablation of the Isthmus between the inferior vena cava and tricuspid annulus for the treatment of atrial flutter. : A study in the canine atrial flutter model." Circulation. 92. 1312-1319 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okumura K. et al.: "Effect of Brain(B-type)natriuretic peptide on coronary artery diameter and coronary hemodynamic variables in humans: comparison with effects on systemic hemodynamic variables" J Am Coll cardiol. 25. 342-348 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Matsunaga T, et al.: "Role of adenosine in regulation of coronary flow in dogs with inhibited synthesis of endothelium-derived nitric oxide" Am J Physiol. 270. H427-H434 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Okumura, et al.: "Diffuse disorder of coronary artery vasomotility in patients with coronary spastic angina: Hyperreactivity to the constrictor effects of acetylcholine and the dilator effects of nitroglycerin." J Am Coll Cardiol. 27. 45-52 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] R.Tsunoda, et al.: "Enhancement of myocardial reactive hyperemia with manganese-superoxide dismutase: role of endothelium-derived nitric oxide" Cardiovasc Res. (in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Matsunaga, et al.: "Impairment of coronary Blood flow regulation by Endothelium-derived nitric oxide in Alloxan-Induced Diabetic Dogs" J Cardiovasc Pharmacol. (in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tsunoda R,et al: "Influence of the inhibition of endothelium-derived nitric oxide formation to the effects vasoconstrictor agents, neuropeptide Y,clonidine and ergonovine and ergonovine, on coronary vascular resistance." J Cadiovasc Pharmacol. 24. 87-94 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Matsunaga T,et al.: "Effect of cumulative dose of NG-nitro-L-arginine methyl ester on coronary blood flow of anesthetized and conscious dogs." Arch Int Pharmacody. 327. 251-265 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tsunoda R,et al.: "Vasodilator Effect of Carboxy-2-Phenyl-4,4,5,5-Tetramethylimidasoline-1-Oxyl in the Coronary Circulation : in Vivo and in Vitro Studies" Eur.J.Pharmacol. 47. 21-29 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Tabuchi T.et al.: "Linear ablation of the Isthmus between the inferior vena cava and tricuspid annulus for the treatment of atrial flutter. : A study in the canine atrial flutter model." circulation. 92. 1312-1319 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Okumura K.et al.: "Effect of Brain (B-type) natriuretic peptide on coronary artery diameter and coronary hemodynamic variables in humans : comparison with effects on systemic hemodynamic variables" J Am Coll Cardiol. 25. 342-348 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Matsunaga T.et al.: "Role of adenosine in regulation of coronary flow in dogs with inhibited synthesis of endothelium-derived nitric oxide" Am J Physiol. 270. H427-H434 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] K.Okumura, et al.: "Diffuse disorder of coronary artery vasomotility in patients with coronary spastic angina : Hyperreactivity to the constrictor eddects of acetylcholine and the dilator effects of nitroglycerin." J Am Coll Cardiol. 27. 45-52 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] R.Tsunoda, et al.: "Enhancement of myocardial reactive hyperemia with manganese-superoxide dismutase : role of endothelium-derived nitric oxide" Cardiovasc Res. (in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Matsunaga, et al.: "Impairment of coronary Blood flow regulation by Endothelium-derived nitric oxide in Alloxan-Induced Diabetic Dogs" J Cardiovasc Pharmacol. (in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] T.Matsunaga,et al.: "Role of adenosine in regulation of coronary flow in dogs with inhibited synthesis of endothelium-derived nitric oxide" Am J Physiol. 270. H427-H434 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] T.Tabuchi,et al.: "Linear ablation of the Isthmus between the inferior vena cava and tricuspid annulus for the treatment of atrial flutter. : A study in the canine atrial flutter model." Circulation. 92. 1312-1319 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] K.Okumura,et al.: "Diffuse disorder of coronary artery vasomotility in patients with coronary spastic angina : Hyperreactivity to the constrictor effects of acetylcholine and the dilator effects of nitroglycerin." J Am Coll Cardiol. 27. 45-52 (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] R.Tsunoda,et al.: "Enhancement of myocardial reactive hyperemia with manganese-superoxide dismutase : role of endothelium-derived nitric oxide" Cardiovasc Res. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] T.Matsunaga,et al.: "Impairment of coronary Blood flow regulation by Endothelium-derived nitric oxide in Alloxan-Induced Diabetic Dogs" J Cardiovasc Pharmacol. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] R.Tsunoda et al.: "Influence of Inhibition of Endothelium-Derived Nitric Oxide Formation to Effects of Vasoconstrictor Agents Neuropeptide Y,Clonidine,and Ergonovine on Coronary Vascular Resistance" Journal of Cardiovascular Pharmacology. 24. 87-94 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] T.Matsunaga et al.: "Effect of Cumulative Doses of NG-Nitro-L-Arginine Methyl Ester on Coronary Blood Flow of Anesthetized and Conscious Dogs" Archives internationales de Pharmacodynamie et de Therapie. 327. 251-265 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] R.Tsunoda et al.: "Vasodilator Effect of Carboxy-2-Phenyl-4,4,5,5-Tetramethylimidazoline-1-Oxyl in the Coronary Circulation:in Vivo and in Vitro Studies" Eur.J.Pharmacol.262. 55-63 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] K.Okumura et al.: "Effects of Brain(B-Type)Natriuretic Peptide on Coronary Artery Diameter and Coronary Hemodynamic Variables in Humans:Comparison With Effects on Systemic Hemodynamic Variables" J.Am.Coll.Cardiol.25. 342-348 (1995)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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