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The featuresof rats with hypertrophic cardiomyopathy and rats with hypertension.

Research Project

Project/Area Number 06670737
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

NAKAGAWA Masao  Kyoto Prefectural University of Medicine, Second Department of Medicine Pfofessor, 医学部, 教授 (30079785)

Project Period (FY) 1994 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1996: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1995: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1994: ¥700,000 (Direct Cost: ¥700,000)
KeywordsWKY / NCrj / Coronary Hemodynamics / Fatty Acid Metabolism / Indomethacin / Neural Crest Cell / SHR / ACE Inhibitor / Angiotensin II Receptor Antagonist / 動脈管 / ACE阻害剤 / Angiotensin II阻害剤 / 心肥大 / 左室拡張能 / 冠血流速波形 / Reactive hyperemia / 冠血管予備能 / WKY.NCrj / 高血圧心 / 肥大型心筋症 / 冠動脈血流波形 / ドプラプローブ / 収縮期逆流
Research Abstract

We clarified the features of rats with hypertrophic cardiomyopathy and rats with hypertension.
1. The features of the coronary blood flow velocity pattern in WKY/NCrj resembled those of human hypertrophic cardiomyopathy (HCM). The abnormal pattern may relate to the abnormal course of the septal perforators.
2. WKY/NCrj had the abnormal fatty acid metabolism especially in anteroseptal and in posteroseptal junction which was often seen in human HCM.This abnormality may relate to the functional disorder of mitochondria.
3. We could produce the rats with cariac hypertrophy resembling human HCM morphologically and functionally by adimistering indomethacin to pregnant near-term rats.
4. We have revealed by using immunohistochestry that there was primarily basic phenotype producing cardiac anomaly in WKY/NCrj. In turn, the cardiac neural crest derived from somite 1 to 3 were disturbed to migrate at 13E ; Moreover by using TUNEL method apoptotic elimination was demonstrated to be augmented in left 6th aortic arch artery at 16-17E.
5. The effects of ACE Inhibitor and Angiotensin II receptor antagonist on cardiac hypertrophy, cardiac function, and coronary circulation in young SHR were assessed. Both drugs similarly prevented cardiac hypertrophy, impairment of left ventricular diastolic function, and impairment to hemodynamics of coronary blood flow in young SHR.
6. The effects of ACE Inhibitor and Angiotensin II Receptor Antagoniston cardiac hypertrophy, cardiac function, and coronary circulation in old SHR were also assesseing now.

Report

(4 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • 1994 Annual Research Report
  • Research Products

    (31 results)

All Other

All Publications (31 results)

  • [Publications] Satoshi Hirasaki: "Septal perforators in Aortic Stenosis and in Hypertrophic Cardiomyopathy:Visualization by Doppler Color Flow Imaging." Circulation. (Suppl.)90. 62-62 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 島 孝友: "肥大型心筋症の超音波組織性状と心筋脂肪酸代謝及び心筋潅流異常" 核医学. 31. 742-742 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Takatomo Shima: "Relationship among abnormalities of the ultrasonic three-layer appearance of the ventricular septum,myocardial fatty acid metabolism and perfusion in patients with hypertrophic cardiomyopathy." Eur J Nucl Med.(Suppl.)21. 174-174 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 平崎智士: "心疾患モデルラットにおける冠血流速波形の解析-微小ドプラプローブを用いて" 超音波医学. (Suppl.1)21. 117-117 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 平崎智士: "心肥大モデルラットにおける冠血流速波形の解析-微小ドプラプローブを用いて" Jpn Circ J.(Suppl.1)59. 285-285 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 寺嶋知史: "肥大型心筋症における心筋虚血の成因:期外収縮後心拍と頻拍時の冠動脈血流速波形の解析" 京府医大誌. 103. 835-854 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Satoshi Hirasaki: "Phasic coronary blood flow velocity in rats with cardiac hypertrophy--using a small Doppler probe--" Jpn Circ J.59. 447-447 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Satoshi Hirasaki: "Phasic coronary blood flow velocity in rats with hypertrophic cardiomyopathy and rats with hypertension." Heart and Vessels.11(Suppl). 78-78 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 大槻克一: "肥大型心筋症における心筋脂肪酸代謝障害に関する研究" 京府医大誌. 105. 561-580 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 島 孝友: "インドメサシンによる胎生末期の動脈管狭窄がラット心の形態および機能に及ぼす影響ヒト肥大型心筋症類似病変の誘発" 京府医大誌. 105. 1047-1067 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 平崎智士: "経時的にみた高血圧心形成に及ぼすACE阻害薬,アンジオテンシンII受容体拮抗薬の効果-SHRでの心エコー図,心臓カテーテル,吸着型微小ドプラプローブによる検討-" 第25回高血圧と内分泌カンファランス抄録集. 6-6 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Satoshi Hirasaki: "Septal perforators in Aortic Stenosis and in Hypertrophic Cardiomyopathy : Visualization by Doppler Color Flow Imaging" Circulation. (Suppl.) 90. 62 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Takatomo Shima: "Hidaikatasinkinshou no tyouonpasoshikiseijou to sinkinshibousantaisha oyobi sinkinkanryuuijou" Jpn. J.Nucl. Med. 31. 742 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Takatomo Shima: "Relationship among abnormalities of the ultrasonic three-layr appearance of the ventricular septum, myocardial fatty acid metabolism and perfusion in patients with hypertrophic cardiomyopathy" Eur J Nucl Med.21 (Suppl.). 174 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Satoshi Hirasaki: "sinnsikkann moderuratto niokeru kannketuryuusokuhakei no kaiseki-bishou dopura puro-bu wo motiite" Jpn. J.Med. Ultrasonics.21 (Suppl.1). 117 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Satoshi Hirasaki: "hidaisinn moderuratto niokeru kannketuryuusokuhakei no kaiseki-bishou dopura puro-bu wo motiite" Jpn Circ J.59 (Suppl.1). 285 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Satoshi Terashima: "Myocardial ischemia in patients with hypertrophic cardiomyoapthy : analysis of coronary flow velocity waveform at the postextrasystolic beat and during tachycardia" J.Kyoto. Pref. Univ. Med.103. 835-854 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Satoshi Hirasaki: "Phasic coronary blood flow velocity in rats with cardiac hypertrophy--using a small Doppler probe-" Jpn Circ J.59. 447 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Satoshi Hirasaki: "Phasic coronary blood flow velocity in rats with hypertrophic cardiomyopathy and rats with hypertension" Heart and Vessels.11 (Suppl). 78 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Katsuichi Ohtsuki: "Impairment of myocardial fatty acid metabolism in patients with hypertrophic cardiomyopathy" J.Kyoto. Pref. Univ. Med.105. 561-580 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Takatomo Shima: "Effects of indomethacin-induced contriction of the ductus arteriosus of near-term fetuses on morphology and function of the heart in rats : Induction of myocardial lesions similar to hypertrophic cardiomyopathy" J.Kyoto. Pref. Univ. Med.105. 1047-1067 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Satoshi Hirasaki: "keijitekini mita kouketuatusinn keisei nioyobosu ACEsogaiyaku anjiotensin juyoutai kikkouyaku no kouka-SHR deno sinneko-zu, sinnzou kate-teru, kyuutyakukata bishou doputapuro-bu niyoru kentou-" dai25kai kouketuatu to naibunnpitu kanfaransu shourokushuu. 6 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] 大槻克一: "肥大型心筋症における心筋脂肪酸代謝障害に関する研究" 京都府立医科大学雑誌. 105. 561-580 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] 島 孝友: "インドメサシンによる胎生末期の動脈管狭窄がラット心の形態および機能に及ぼす影響:ヒト肥大型心筋症類似病変の誘発" 京都府立医科大学雑誌. 105. 1047-1067 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Satoshi Hirasaki: "Phasic coronary blood flow velocity in rats with cardiac hypertrophy--using a small Doppler probe--" Japanese Circulation Journal. 59. 447-447 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Satoshi Hirasaki: "Phasic coronary blood flow velocity in rats with hypertrophic cardiomyopathy and rats with hypertension cardiac hypertrophy" Heart and Vessels. 11(Suppl.). 78-78 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Satoshi Hirasaki: "Septal Perforators in Aortic Stenosis and in Hypertrophic Cardiomyopathy" Circulation(Suppl.). 90. 62-62 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 島 孝友: "肥大型心筋症の超音波組織性状と心筋脂肪酸代謝及び心筋灌流異常" 核医学. 31. 742-742 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Takatomo Shima: "Relationship among abnormalities of the ultrasonic three-layer appearance of the ventricular septum,myocardial fatty acid metabolism and perfusion in patients with hypertrophic cardiomyopathy" European Journal of Nuclcar Medicine. 21(Suppl.). 174-174 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 平崎智士: "心疾患モデルラットにおける冠血流速波形の解析-微小ドプラプローベを用いて" 超音波医学. 21(Suppl.1). 117-117 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 平崎智士: "肥大心モデルラットにおける冠血流波形の解析-微小ドプラプローブを用いて" Japanese Circulation Journal. 59(Suppl.1). 285-285 (1995)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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