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Aberration of TAL1 gene is specifically involved in childhood T-cell leukemia and its functional analysis

Research Project

Project/Area Number 06670772
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionUniversity of Tokyo

Principal Investigator

KOBAYASHI Shigetoshi  Univ.of Tokyo(Hospital)Pediatrics, Assistant Professor, 医学部(病), 助手 (70260487)

Co-Investigator(Kenkyū-buntansha) BESSHO Fumio  Univ.of Tokyo(Hospital)Pediatrics, Associate Professor, 医学部(病), 助教授 (40010285)
HAYASHI Yasuhide  Univ.of Tokyo(Hospital)Pediatrics, Associate Professor, 医学部(病), 講師 (30238133)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1994: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsTAL1 gene / acute lymphoblastic leukemia / T-cell malignancies / minimal residual disease / PCR / tal-1 / T cell leukemia / orcagere / Tal-1 / T細胞性白血病
Research Abstract

Site-specific recombination of the TAL1 gene was analyzed by Southern blotting and polymerase chain reaction (PCR) in 44 cases of childhood T-cell acute lymphoblastic leukemia (T-ALL), 20 cases of childhood T-cell non-Hodgkin's lymphoma (T-NHL) and 35 cases of adult T-cell malignancies.This recombination was found in 10 (22.7%) of 44 childhood T-ALL patients, but in none of the T-NHL or adult T-cell malignancies.Recombination of the TAL1 gene was therefore suggested to be specific for childhood T-ALL.The immunophenotypic features of the 10 T-ALL patients with this recombination were CD1-, CD2+, CD4-, CD7+, CD10-, and they had a significantly better outcome than other T-ALL cases without the recombination.The PCR technique revealed minimal residual disease (MRD) in 4 patients.One showed persistent MRD,while in the other MRD was recognized only at initial diagnosis. Further investigation is needed whether T-ALL with this recombination constitutes a distinct clinical subgroup among childhood T-ALL patients.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Kawamura M,et al.: "Mutations of the p53 and ras genes in childhood t(1;19)-acute lymphoblastic" Blood. 85. 2546-2552 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ohuishi H,et al.: "Homozygous deletion of p16/MTS1 gene are frequent but mutations are infrequent in childhood T-cell acute lymphoblastic" Blood. 86. 1269-1275 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kobayashi S,et al.: "Mutations of the Btk gene in twelve unrelated families with X-linked agammaglobulinemia in Japan : Immunological phenotypes are inconsistent with the location of the mutations" Human Genet. 97. 424-430 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ohnishi H,et al.: "Homozygous deletions of p16/MTS1 and p15/MTS2 genes in t(1;19)-negative but not in t(1;19)-positive B precursor acute lymphoblastic leukemia in childhood." Leukemta. 10. 1104-1110 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Taki T,et al.: "Frequency and clinical significance of the MLL gene rearrangements in infant acute leukemia" Leukemia. 10. 1303-1307 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kikuchi A,et al.: "TAL1 Gene Analysis in T-cell Malignancies" Rinsho Ketsueki. 39. 259-266 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kawamura M,Hayashi Y,Kobayashi S,Kikuchi A et al.: "Mutations of the p53 and ras genes in childhood t(1 ; 19)-acute lymphoblastic leukemia" Blood. 85. 2546-2552 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ohnishi H,Kawamura M,Ida K,Hanada R,Hayashi Y,et al.: "Homozygous deletion of p16/MTS1 gene are frequent but mutations are infrequent in childhood T-cell acute lymphoblastic leukemia." Blood. 86. 1269-1275 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kobayashi, S,Iwata T,Saito M,Iwasaki R,Matsumoto H,Hirata S,Kono Y,Hayashi Y.: "Mutations of the Btk gene in twelve unrelated families with X-linked agammaglobulinemia in Japan : Immunological phenotypes are inconsistent with the location of the mutations" Human Genet. 97. 424-430 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ohnishi H,Hanada R,Kawamura M,Bessho F,Hayashi Y,et al.: "Homozygous deletions of p16/MTS1 and p15/MTS2 genes in t(1 ; 19)-negative but not in t(1 ; 19)-positive B precursor acute lymphoblastic leukemia in childhood." Leukemia. 10. 1104-1110 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Taki T,Ida K,Bessho F,Hanada R,Kikuchi A,Hayashi Y,et al.: "Frequency and clinical significance of the MLL gene rearrangements in infant acute leukemia" Leukemia. 10. 1303-1307 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kikuchi A,et al.: "TAL1 Gene Analysis in T-cell Malignancies" Rinsho Ketsueki. 39. 259-266 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary

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Published: 1994-04-01   Modified: 2016-04-21  

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