• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis of immunological reconstitution after allogeneic bone marrow transplantation

Research Project

Project/Area Number 06670778
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionYamanashi Medical University

Principal Investigator

SUGITA Kanji  Yamanashi Medical University, Pediatrics, Assistant, 医学部, 助手 (60138055)

Co-Investigator(Kenkyū-buntansha) GOI Kumiko  Yamanashi Medical University, Pediatrics, Staff, 医学部, 医員
IIJIMA Kiyomu  Yamanashi Medical University, Pediatrics, Staff, 医学部, 医員
SAITO Midori  Yamanashi Medical University, Pediatrics, Assistant, 医学部, 助手 (20170532)
Project Period (FY) 1994 – 1996
Project Status Completed (Fiscal Year 1996)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1996: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1995: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1994: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywordsallogeneic bone marrow transplantation / T cell dysfunction / CD28 / CD29 / CD29 / 免疫学的再構築 / T細胞
Research Abstract

Although allogeneic bone marrow transplantation (allo-BMT) is an important therapeutic approach for the treatment of malignant diseases, opportunistic infection and graft-versus-host disease (GVHD), in which T cells included in grafts are involved, must be well controled. In this study, we examined T cell reconstitution after allo-BMT in terms of T cell-related antigen expression and T cell activation pathways. The expression of CD2, CD3, and CD8 bacame normal at 1 month, 3 month, and 6 month, respectively, post allo-BMT.However, recovery of CD4 expression was impaired more than 1 year, thus resulting in long-term low CD4/CD8 ratio. Among T cell activation pathways, the CD28 pathway, which is sensitive to glucocorticoid but resistant to cyclosporin, recovered within 3 months, suggesting an important role of this pathway in T cell activation involved in acute GVHD.The CD29 (VLA beta-chain) expression was significantly increased in cases with severe GVHD,which suggests an crucial role of adhesion molecules in development of GVHD.Clarification of T cell development and dysfunction post allo-BMT will provide a theoretical basis with therapeutic approach to GVHD.

Report

(4 results)
  • 1996 Annual Research Report   Final Research Report Summary
  • 1995 Annual Research Report
  • 1994 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Kanji Sugita: "Phenotype and reconstitution ofimmunoregulatory T cell subsets after T cell depleted allogeneic and autologous bone marrow transplantation." Transplantation. 57. 1465-1473 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kanji Sugita: "Prolonged impairment of very late activating antigen-mediated T cell proliferation via the CD3 pathway after T cell-depleted allogeneic bone marrow transplantaion." J. Clin. Invest. 94. 481-488 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Jun Kameoka: "Differential CD26 mediated activation of the CD3 and CD2 pathways after CD6-depleted allogeneic bone marrow transplantation." Blood. 85. 1132-1137 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Sugita K,Soifer RJ,Murray C,Schlossman SF,Ritz J,Morimoto C.: "Phenotype and reconstitution of immunoregulatory T cell subsets after T cell depleted allogeneic and autologous bone marrow transplantation." transplantation. 57. 1465-1473 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Sugita K,Nojima Y,Tachibana K,Soiffer RJ,Murray C,Schlossman SF,Ritz J,Morimoto C.: "Prolonged impairment of very late activating antigen-mediated T cell proliferation via the CD3 pathway after T cell-depleted allogeneic bone marrow transplantaion." J.Clin.Invest. 94. 481-488 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Kameoka J,Sato T,Torimoto Y,Sugita K: "Soiffer RJ,Schlossman SF,Ritz J,Morimoto C.Differential CD26 mediated activation of the CD3 and CD2 pathways after CD6-depleted allogeneic bone marrow transplantation." Blood. 85. 1132-1137 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1996 Final Research Report Summary
  • [Publications] Inukai T: "A novel 203 KD-aberrant BCR-ABL product in a girl with philadelphia chromosome positive acute lymphoblastic leukaemia." Brit.J.Haematol.85. 823-825 (1993)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sugita K: "Phenotype and reconstitution of immunoregulatory T cell subsets after T cell depleted allogeneic and autologous bone marrow transplantation." Transplantation. 57. 1465-1473 (1994)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sugita K: "Prolonged impairment of very late activating antigen-mediated T cell proliferation via the CD3 pathway after T cell-depleted allogeneic bone marrow transplantaion." J.Clin.Invest. 94. 481-488 (1994)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kameoka J: "Differential CD26 mediated activation of the CD3 and CD2 pathways after CD6-depleted allogeneic bone marrow transplantation." Blood. 85. 1132-1137 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Mori T: "KOR-SA3544 : a novel monoclonal antibody which reacts with Philadelphia chromosome positive acute lymphoblastic leukemia cells with high sensitivity." Leukermia. 9. 1233-1239 (1995)

    • Related Report
      1996 Annual Research Report
  • [Publications] Kojika S: "Mechanisms of glucocorticoid resistance in human leukemic cells : Implication of abnormal heat shock proteins 90 and 70." Leukemia. 10. 994-999 (1996)

    • Related Report
      1996 Annual Research Report
  • [Publications] Sugita K: "Phenotype and reconstitution of immunoregulatory T cell subsets after T cell depleted allogeneic and autologous bone marrow transplantation." Transplantation. 57. 1465-1473 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] Sugita K: "Prolonged impairment of very late activating antigen-mediated T cell proliferation via the CD3 pathway after T cell-depleted allogeneic bone marrow tansplantation." J Clin Invest. 94. 481-488 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 杉田完爾: "抗リン酸化チロシン抗体を用いたPh1陽性急性リンパ性白血病の診断" 医学のあゆみ. 170. 966-968 (1994)

    • Related Report
      1995 Annual Research Report
  • [Publications] 杉田完爾: "小児血液・悪性腫瘍疾患に伴う重症感染症に対するImipenem/Cilastatin sodiumとAmikacin sulfateの併用投与-第一選択薬としての臨床検討-" 小児科臨床. 48. 2395-2399 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Inukai T: "Expression of geanulocute colony-stimulating factor receptor on CD10-positive human B-cell precursor." Brit J Haematol. 89. 623-626 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Mori T: "A novel monoclonal antibody, KOR-SA3544 which reactes to Philadephia chromosome-positive acute lymphoblastic leukemia cells with high sensitivity." Leukemia. 9. 1233-1239 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Inukai.T: "Analysis of cytoplasmic and surface antigen in childhood T-cell acute lymphoblastic leukemias:clinical relevance of cytoplasmic TCR β chain." Brit.J.Haematol.87. 273-281 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Sugita.K.: "Phenotype and reconstitution of immunoregulatory T cell subsets after T cell depleted allogeneic and autologous bone marrow transplantation." Transplantation. 57. 1465-1473 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Sugita.K.: "Prolonged impairment of very late activationg antigen-mediated T cell proliferation via the CD3 pathway after T cell-depleted allogeneic bone marrow transplantaion." J.Clin.Invest.94. 1421-1429 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Agematsu.K.: "Role of CD27 in T cell immune response-analysis by recombinant soluble CD27." J.Immunol.153. 1421-1429 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Wada.H.: "Clonal expansion of p53 mutant cell in leukemia progression in vitro." Leukemia. 8. 53-59 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 杉田完爾: "抗リン酸化チロシン抗体を用いたPh′陽性急性リンパ性白血病の診断" 医学のあゆみ. 170. 966-968 (1994)

    • Related Report
      1994 Annual Research Report

URL: 

Published: 1994-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi