| Project/Area Number |
06670778
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Yamanashi Medical University |
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Principal Investigator |
SUGITA Kanji Yamanashi Medical University, Pediatrics, Assistant, 医学部, 助手 (60138055)
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| Co-Investigator(Kenkyū-buntansha) |
GOI Kumiko Yamanashi Medical University, Pediatrics, Staff, 医学部, 医員
IIJIMA Kiyomu Yamanashi Medical University, Pediatrics, Staff, 医学部, 医員
SAITO Midori Yamanashi Medical University, Pediatrics, Assistant, 医学部, 助手 (20170532)
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| Project Period (FY) |
1994 – 1996
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| Project Status |
Completed (Fiscal Year 1996)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1996: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1995: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1994: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | allogeneic bone marrow transplantation / T cell dysfunction / CD28 / CD29 / CD29 / 免疫学的再構築 / T細胞 |
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| Research Abstract |
Although allogeneic bone marrow transplantation (allo-BMT) is an important therapeutic approach for the treatment of malignant diseases, opportunistic infection and graft-versus-host disease (GVHD), in which T cells included in grafts are involved, must be well controled. In this study, we examined T cell reconstitution after allo-BMT in terms of T cell-related antigen expression and T cell activation pathways. The expression of CD2, CD3, and CD8 bacame normal at 1 month, 3 month, and 6 month, respectively, post allo-BMT.However, recovery of CD4 expression was impaired more than 1 year, thus resulting in long-term low CD4/CD8 ratio. Among T cell activation pathways, the CD28 pathway, which is sensitive to glucocorticoid but resistant to cyclosporin, recovered within 3 months, suggesting an important role of this pathway in T cell activation involved in acute GVHD.The CD29 (VLA beta-chain) expression was significantly increased in cases with severe GVHD,which suggests an crucial role of adhesion molecules in development of GVHD.Clarification of T cell development and dysfunction post allo-BMT will provide a theoretical basis with therapeutic approach to GVHD.
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