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Isolation of a novel nephritogenic cationic protein from Streptococcus pyogenes

Research Project

Project/Area Number 06670801
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionTOKUSHIMA UNIVERSITY

Principal Investigator

OKADA Kaname  Tokushima University, University Hospital of School of Medicine, Lecturer, 医学部・附属病院, 講師 (10169104)

Co-Investigator(Kenkyū-buntansha) KURODA Yasuhiro  Tokushima University, School of Medicine, Professor, 医学部, 教授 (20035471)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1994: ¥1,600,000 (Direct Cost: ¥1,600,000)
KeywordsCationic protein / Nephritogenic antigen / Streptococcus pyogenes / Glomerulonephritis
Research Abstract

Streptococcal cationic protein (SCP), appearing as a band of 10 kDa on SDS gels and pI>9.0, was purified from the nephritogenic strain of the patients with acute poststreptococcal glomerulonephritis. This protein had a high affinity to the glomerular structure. The rats injected twice with 150 mug of SCP at one week interval developed proteinuria and diffuse mesangial proliferative glomerulonephritis. By immunofluorescence, the deposits of rat IgG and C3 were localized in the mesangium and partly along the capillary wall. No remarkable renal changes were found in the kidney of control rats. These results suggest that SCP may be an unique bacterial antigen which induces glomerulonephritis through in situ immune complex formation.

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] 岡田要,久原孝,安友康二,香美祥二: "A群β溶連菌塩基性蛋白による実験腎炎" 日本腎臓学会誌. 37(supple). 145- (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kaname Okada, Takashi Kuhara, Koji Yasutomo, Shoji Kagami: "Experimental glomerulonephritis caused by a novel cationic protein from Streptococcus pyogenes (Japanese)." Jap J Nephrol. 37 (Supple.). 145 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] 岡田要,久原孝,安友康二,香美祥二: "A群β溶連菌塩基性蛋白による実験腎炎" 日本腎臓学会誌. 37(supple). 145- (1995)

    • Related Report
      1995 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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