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Correlation of Lipoprotein Abnormalities in Childhood withe the Risk for Atherosclerotic Coronary Heart Disease (CAD) in Adulthood (Is abnormaltites in childhood a risk factor for CAD? )

Research Project

Project/Area Number 06670809
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionKumamoto University

Principal Investigator

OHTA Takao  Kumamoto University School of Medicine, Department of Pediatrics, Lecturer., 医学部, 講師 (70185271)

Co-Investigator(Kenkyū-buntansha) SAKU Keijiro  Fukuoka University, Department of Internal Medicine, Lecturer, 医学部, 講師 (40183371)
Project Period (FY) 1994 – 1995
Project Status Completed (Fiscal Year 1995)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1995: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1994: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsLpA-I / A-II / Atherosclerosis / FERHDL / LDL size / Small LDL / small LDL / LDL size / LpA-1 / A-II
Research Abstract

1.We investigated the effects of subclasses of LpA-I [high density lipoprotein (HDL) containing only apoA-I] on cholesterol esterification in plasma and net cholestrol efflux from foam cells. LpA-I was composed of particles of three different sizes : large (Lg-LpA-I), medium (Md-LpA-I) and small (Sm-LpA-I). Plasma concentrations of LpA-I were positively correlated only with the level of Lg-LpA-I.Plasma concentrations of Lg-LpA-I were inversely correlated with the rate of cholesterol esterification in plasma and VLDL and LDL-depleted plasma (FERplasma and FER_<HDL>). When macrophage foam cells were incubated with Md-and Sm-LpA-I,cellular cholesterol mass was reduced by approximately 70%. In contrast, the cellular cholesterol-reducing capacity of Lg-LpA-I was negligible. Lg-LpA-I inhibited net cholesterol removal from foam cells that was mediated by Md-and Sm-LpA-I and cholesteryl ester production with these particles. These results suggest that Md-and Sm-LpA-I may actively participate i … More n cellular cholesterol removal and cholesterol esterification in plasma and HDL,while Lg-LpA-I may regulate these functions of Md-and Sm-LpA-I.
2.We examined the correlations between low-density-lipoprotein (LDL) particle size and both FER_<HDL> and plasma lipid levels. FER_<HDL> and plasma triglyceride were negatively, and HDL-cholesterol was positively, correlated with LDL particle size (r=-0.728, -0.598and0.572, p>0.0001). Stepwise multiple regression analysis revealed that FER_<HDL> was most significantly associated with LDL particle size. Since FER_<HDL> is regulated by the plasma consentration of LpA-I (HDL containig apoA-I but not apoA-II), which is the anti-atherogenic fraction of HDL,the present results suggest that the regulation of LDL particle size may be part of the anti-atherogenic nature of LpA-1.
3.Qualitative and quantitative changes of LpA-I in children with low plasma LpA-I were indistinguishable from those in patients with coronary artery disease (CAD) with low plasma LpA-I.All of our data suggest that children with low plasma LpA-I are high risk for CAD. Less

Report

(3 results)
  • 1995 Annual Research Report   Final Research Report Summary
  • 1994 Annual Research Report
  • Research Products

    (41 results)

All Other

All Publications (41 results)

  • [Publications] Kajikawa Mikio: "Lactoferrin inhibits cholesterol accumulation in macrophages mediated by acetylated or oxidized low density lipoproteins." Biochim Biophys Acta. 1213. 82-90 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Saku Keijiro: "Plasma HDL levels are regulated by the catabolic rate of large particles of lipoprotein containing apoA-I." Biochem Biophys Res Commun. 200. 557-561 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ohta Takao: "Evidence for impaired cellular cholesterol removal mediated by apoA-I-containing lipoproteins in patients with familial lecithin: cholesterol acyltransferase deficiency." Biochim Biophys Acta. 1213. 295-301 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ohta Takao: "Characterization of subspecies of apolipoprotein A-I containing lipoprotein in homozygotyes for familial lecithin: cholesterol acyltransferase deficiency." Arterioscler. Thromb. 14. 1137-1145 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ohta Takao: "Inverse relation of plasma concentrations of apoA-I-containing lipoprotein with no apoA-II(LpA-I)to plasma cholesterol esterification rats and cellular cholesterol reducing capacity of LpA-I." Atherosclerosis. 109. 226(a)- (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Saku Keijiro: "Plasma HDL levels are regulated by the catabolic rate of large particles of lipoprotein containing apoA-I." Circulation. 90(II). I-82- (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ikeda Yoichiro: "Interaction between apoA-I-containing lipoproteins and lecithin: cholesterol acyltransferase." Biochim Biophys Acta. 1215. 307-313 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ohta Takao: "Characterization of subspecies of lipoprotein containing apolipoprotein A-I in heterozygotes for familial lecithin: cholesterol acyltransferase deficiency." Atherosclerosis. 114. 147-155 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ohta Takao: "Structural and functional differences of subspecies of apoA-I-containing lipoproteins in patients with plasma cholesteryl ester transfer protein deficiency." J Lipid Res. 36. 696-704 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ohta Takao: "Different effects of subclasses of HDL containing apoA-I(LpA-I)on cholesterol esterification in plasma and net cholesterol efflux from foam cells." Arterioscler Thromb Vasc Biol. 15. 956-962 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takata Kouki: "A new case of apoA-I deficiency showing codon 8 nonsense mutation of the apoA-I gene without evidence of coronary heart disease." Arterioscler Thromb Vasc Biol. 15. 1866-1874 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Miyazaki Akira: "Intravenous injection of rabbit apolipoprotein A-I inhibits the progression of atherosclerosis in cholesterol-fed rabbits." Arterioscler Thromb Vasc Biol. 15. 1882-1888 (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Suginohara Yoshiko: "The heparin-bound fraction of human lipoprotein-deficient serum inhibits endocytic uptake of oxidized low density lipoprotein by macrophages." Atherosclerosis. 120. 167-179 (1996)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Kajikawa Mikio: "Lactoferrin inhibits cholesterol accumulation in macrophages mediated by acetylated or oxidized low density lipoproteins" Biochim Biophys Acta. 1213. 82-90 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Saku Keijiro: "Plasma HDL levels are regulated by the catabolic rate of large particles of lipoprotein containing apoA-I" Biochim Biophys Res Commun. 200. 557-561 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ohta Takao: "Evidence for impaired cellular cholesterol removal mediated by apoA-I-containing lipoproteins in patients with familial lecithin : cholesterol acyltransferase deficiency." Biochem Biophys Acta. 1213. 295-301 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ohta Takao: "Characterization of subspecies of apolipoprotein A-I containing lipoprotein in homozygotyes for familial lecithin : cholesterol acyltransferase deficiency." Arterioscler. Thromb. 14. 1137-1145 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ohta Takao: "Inverse relation of plasma concentrations of apoA-I-containing lipoprotein with no apoA-II (LpA-I) to plasma cholesterol esterification rates and cellular cholesterol reducing capacity of LpA-I" Atherosclerosis. 109. 226a (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Saku Keijiro: "Plasma HDL levels are regulated by the catabolic rate of large particles of lipoprotein containing apoA-I" Circulation. 90 (II). I-82 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ikeda Yoichiro: "Interaction between apoA-I-containing lipoproteins and lecithin : cholesterol acyltransferase" Biochim Biophys Acta. 1215. 307-313 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ohta Takao: "Characterization of subspecies of lipoprotein containing apolipoprotein A-I in heterozygotes for familial lecithin : cholesterol acyltransferase deficiency" Atherosclerosis. 114. 147-155 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ohta Takao: "Structural and functional differences of subspecies of apoA-I-containing lipoproteins in patients with plasma cholesteryl ester tranfer protein deficiency" J Lipid Res. 36. 696-704 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ohta Takao: "Different effects of subckasses of HDL containing apoA-I (LpA-I) on cholesterol esterification in plasma and net cholesterol efflux from foam cells" Arterioscler Thromb Vasc Biol. 15. 956-962 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Takata Kouki: "A new case of apoA-I deficiency showing codon 8 nonsense mutation of the apoA-I gene without evidence of coronary heart disease" Arterioscler Thromb Vasc Biol. 15. 1866-1874 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Miyazaki Akira: "Intravenous injection of rabbit apolipoprotein A-I inhibits the progression of atherosclerosis in cholesterol-fed rabbits" Arterioscler Thromb Vasc Biol. 15. 1882-1888 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Suginohara Yoshiko: "The heparin-bound fraction of human lipoprotein-deficient serum inhibits endocytic uptake of oxidized low density lipoprotein by macrophages" Atherosclerosis. 120. 167-179 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1995 Final Research Report Summary
  • [Publications] Ohta Takao: "Characterization of subspecies of lipoprotein containing apolipoprotein A-I in heterozygotes for familial lecithin : cholesterol acyltransferase deficiency." Atherosclerosis. 114. 147-155 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ohta Takao: "Structural and functional differences of subspecies of apoA-I-containing lipoproteins in patients with plasma cholesteryl ester transfer protein deficiency." J Lipid Res. 36. 696-704 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Ohta Takao: "Different effects of subclasses of HDL containing apoA-I (LpA-I) on cholesterol esterification in plasma and net cholesterol efflux from foam cells." Arterioscler Thromb Vasc Biol. 15. 956-962 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Takata Kouki: "A new case of apoA-I deficiency showing codon 8 nonsense mutation of the apoA-I gene without evidence of coronary heart disease." Arterioscler Thromb Vasc Biol. 15. 1866-1874 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Miyazaki Akira: "Intravenous injection of rabbit apolipoprotein A-I inhibits the progression of atherosclerosis in cholesterol-fed rabbits." Arterioscler Thromb Vasc Biol. 15. 1882-1888 (1995)

    • Related Report
      1995 Annual Research Report
  • [Publications] Suginohara Yoshiko: "The heparin-bound fraction of human lipoprotein-deficient serum inhibits endocytic uptake of oxidized low density lipoprotein by macrophages." Atherosclerosis. (in press). (1996)

    • Related Report
      1995 Annual Research Report
  • [Publications] Kajikawa Mikio: "Lactoferrin inhibits cholesterol accumulation in macrophages mediated by acetylated or oxidized low density lipoproteins." Biochim Biophys Acta. 1213. 82-90 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Saku Keijiro: "Plasma HDL levels are regulated by the catabolic rate of large particles of lipoprotein containing apoA-I." Biochem Biophys Res Commun. 200. 557-561 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ohta Takao: "Evidence for impaired cellular cholesterol removal mediated by apoA-I-containing lipoproteins in patients with familial lecithin:cholesterol acyltransferase deficiency." Biochim Biophys Acta. 1213. 295-301 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ohta Takao: "Characterization of subspecies of apolipoprotein A-I containing lipoprotein in homozygotyes for familial lecithin:cholesterol acyltransferase deficiency." Arteriosclerosis and Thrombosis. 14. 1137-1145 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ohta Takao: "Inverse relation of plasma concentrations of apoA-I-containing lipoprotein with no apoA-II(LpA-I) to plasma Cholesterol Esterification Rates and Cellular Cholesterol Reducing Capacity of LpA-I." Atherosclerosis. 109. 226(a) (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Saku Keijiro: "Plasma HDL levels are regulated by the catabolic rate of large particles of lipoprotein containing apoA-I." Circulation. 90(II). I-82 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ikeda Yoichiro: "Interaction between apoA-I-containing lipoproteins and lecithin:cholesterol acyltransferase" Biochim Biophys Acta. 1215. 307-313 (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ohta Takao: "Structural and functional differences of subspecies of apoA-I-containing lipoproteins in patients with plasma cholesteryl ester transfer protein deficiency." Journal of Lipid Research. (in press). (1995)

    • Related Report
      1994 Annual Research Report
  • [Publications] Ohta Takao: "Characterization of Subspecies of Lipoprotein Containing Apolipoprotein A-I in Heterozygotes for Familial Lecithin:Cholesterol Acyltransferase Deficiency." Atherosclerosis. (in press). (1995)

    • Related Report
      1994 Annual Research Report

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Published: 1994-04-01   Modified: 2016-04-21  

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