| Project/Area Number |
06670814
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | YOKOHAMA CITY UNIVERSITY |
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Principal Investigator |
YOKOTA Shumpei YOKOHAMA CITY UNIVERSITY, 医学部・小児科, 講師 (10158363)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Masaaki YOKOHAMA CITY UNIVERSITY, 医学部・小児科, 助手 (30254204)
AIHARA Yukoh YOKOHAMA CITY UNIVERSITY, 医学部・小児科, 講師 (50211686)
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| Project Period (FY) |
1994 – 1995
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| Project Status |
Completed (Fiscal Year 1995)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1995: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1994: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | EPSTEIN-BARR VIRUS / CYTOKINES / DISEASE-ACTIVITY / FERRITIN / CYCLOSPORIN A / TARGETTING THERAPY / リポ化ステロイド / サイクロスポリンA / 慢性活動性EBウイルス感染症 |
|---|
| Research Abstract |
Firstly we established the PCR detection system for EB virus using primers originated from IR1 gene sequences. The detection system was useful, and detected EBV genome in mononuclear cells in peripheral blood, inflammatory cells in pleural effusion, and bone marrow cells. The activated macrophages and lymphocytes were the populations of the exudative cells. The disease activity of chronic active EBV infection and virus-associated hemophagocytic syndrome was monitered well by AST,ALT,LDH,fibrinogen-fibrin degrades (FDP-E,D dimer), and serum ferritin. Cytokines originated from activated macrophages and T cells were abnormally high in these diseases, and the regulatory imbalances of these cytokines may be contributed to generalized vasculitis. Therapy was initiated to stabilize macrophages and T cells by administratiog lipo-dezamethasone and cyclosporin A.
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